Palmitamidopropylamine Oxide: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Palmitamidopropylamine Oxide?

Palmitamidopropylamine oxide is a mild surfactant created from palmitic acid, a fatty acid most often sourced from palm or coconut oil. Chemists react palmitic acid with dimethylaminopropylamine to form an amide then gently oxidize the amine group to produce the final amine oxide structure. This yields a water loving head and an oil loving tail, a balance that lets the ingredient interact with both oils and water.

Amine oxides entered cosmetic labs in the 1950s as gentler alternatives to the harsher soaps of the time. Their ability to clean without stripping made them popular in early baby shampoos then in mainstream hair and skin care. Palmitamidopropylamine oxide is one of the newer, longer chain versions, prized for its creamy foam and soft feel.

Today you will most often spot it in shampoos, conditioners, body washes, liquid hand soaps, facial cleansers, bubble baths, detangling sprays and hair masks. It is typically used at low percentages to round out a formula, boost foam and improve how the product rinses off.

Palmitamidopropylamine Oxide’s Cosmetic Benefits/Uses

This ingredient wears several hats inside a formulation, each bringing a specific benefit

  • Antistatic: Helps prevent flyaways by reducing the static charge that builds up on hair strands so hair looks smoother and is easier to manage
  • Cleansing: Lifts away dirt oil and product buildup without the harshness of traditional soaps making it suitable for daily use
  • Hair conditioning: Leaves a light conditioning film that improves slip and combability which is why it often appears in 2 in 1 shampoos and co washes
  • Foam boosting: Enhances the volume and stability of lather giving users the rich bubbly texture they expect from a cleanser
  • Hydrotrope: Helps keep oils fragrances and other tricky ingredients evenly dispersed so the formula stays clear and uniform over time

Who Can Use Palmitamidopropylamine Oxide

Because it is a mild surfactant, palmitamidopropylamine oxide generally works for dry, normal, combination and oily skin types. Even sensitive skin often tolerates it thanks to its low irritation profile, though people with hypersensitive or compromised skin should still watch how their skin feels, as with any new cleanser.

The ingredient is usually plant derived from palm or coconut oil, so it is suitable for vegans and vegetarians. If you follow a strict cruelty free routine, check that the finished product and its raw materials were not tested on animals.

No evidence suggests that palmitamidopropylamine oxide poses a risk to women who are pregnant or breastfeeding when used in wash off cosmetics. This is not medical advice and anyone who is expecting or nursing should discuss any skincare product with a qualified health professional just to be safe.

The ingredient does not increase photosensitivity, so it will not make skin more prone to sunburn. It is also color safe for most dyed hair and is gentle enough for children’s bath products.

Potential Side Effects/Adverse Reactions

Reactions to topical palmitamidopropylamine oxide vary from person to person. The points below list potential side effects that could occur, but they are not the norm when the ingredient is used correctly in a finished product.

  • Mild skin irritation such as redness or itching, especially on very sensitive skin
  • Transient eye stinging if the cleanser accidentally gets into the eyes
  • Allergic contact dermatitis in rare cases for individuals sensitized to amine oxides
  • Dryness or tightness when formulas contain a high percentage of surfactants overall

If you experience any of the reactions above discontinue use and consult a healthcare professional if symptoms persist.

Comedogenic Rating

Palmitamidopropylamine oxide scores a 1 out of 5 on the comedogenic scale. It is a large, water soluble surfactant that rinses off the skin instead of soaking in, so it has very little chance of blocking pores. Because of this low score it is generally fine for people who are prone to acne or breakouts. As with any cleansing ingredient the risk of clogged pores rises only if the final formula is packed with heavy oils or if it is not rinsed away fully.

Summary

Palmitamidopropylamine oxide works as a gentle cleaner, foam booster, light conditioner, antistatic agent and hydrotrope. Its split personality head loves water while its tail loves oil, letting it lift dirt and oil, build a creamy lather and leave hair easier to comb. You will spot it most often in shampoos, body washes and kids bath products rather than in high end serums, so it is useful but not exactly a household name.

Safety studies and decades of use show a low risk of irritation or allergy when this ingredient is used in rinse off formulas at normal levels. Still, skin can be unpredictable, so it is smart to patch test any new product that contains it just to be sure your skin stays happy.

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