What Is Palmitoyl Sh-Tripeptide-2 Amide?
Palmitoyl Sh-Tripeptide-2 Amide is a lab-crafted peptide that combines a short chain of three amino acids with a fatty acid called palmitic acid. The fatty acid helps the peptide slip into the skin surface while the peptide part is modeled after a fragment of the Tumor Necrosis Factor Receptor 2 protein, a natural cell messenger found in the body. Scientists began exploring this fragment for skin care when early studies hinted that it could help calm the look of stressed skin and improve firmness. To make the ingredient, manufacturers start with plant-derived palmitic acid, link it to the synthetic tripeptide through a safe chemical reaction, then purify the result into a fine powder ready for cosmetic use.
You will most often spot Palmitoyl Sh-Tripeptide-2 Amide in anti-aging serums, firming creams, eye treatments, sheet masks and richer moisturizers aimed at mature or dehydrated skin. Product developers like it because it works well in both water-based and oil-based systems and stays stable across a broad pH range.
Palmitoyl Sh-Tripeptide-2 Amide’s Cosmetic Benefits/Uses
In formulas this peptide serves several helpful roles that support healthy looking skin.
- Humectant: Draws water from the deeper skin layers and the air to the surface, helping skin stay plump and comfortable. This extra moisture can soften fine lines and give a dewy finish.
- Skin Conditioning: Smooths and softens the outer layer so skin feels silky and looks more even. Regular use can improve the appearance of firmness and elasticity.
- Skin Protecting: Forms a light breathable film that shields against daily irritants like pollution and dry air, helping to maintain the skin’s natural barrier and reduce visible signs of stress.
Who Can Use Palmitoyl Sh-Tripeptide-2 Amide
This peptide suits most skin types including dry, normal, combination and oily because it is lightweight and non-greasy while still delivering moisture. Sensitive skin usually tolerates it well since it is fragrance free and low in irritants, though anyone with a known peptide allergy should be cautious. Acne-prone users often appreciate that it does not clog pores or leave a heavy film.
The ingredient is synthesized in the lab and the palmitic acid it contains is typically sourced from plants so it is considered suitable for vegans and vegetarians as long as the final formula does not add animal-derived extras.
No data points to problems for pregnant or breastfeeding women when this peptide is applied topically in cosmetic concentrations. It does not penetrate deeply or enter the bloodstream in meaningful amounts. That said this is not medical advice and anyone who is pregnant or nursing should review any skincare routine with a qualified healthcare provider to be safe.
Palmitoyl Sh-Tripeptide-2 Amide does not increase photosensitivity so it can be used morning or night without raising sunburn risk, although daily sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Palmitoyl Sh-Tripeptide-2 Amide vary from person to person. The points below describe potential issues and are not expected to be the typical experience when the ingredient is used in well-formulated products.
- Temporary redness or warmth
- Mild itching or tingling right after application
- Localized irritation in very sensitive or compromised skin
- Rare allergic contact dermatitis characterized by persistent rash or swelling
If any uncomfortable reaction develops discontinue use and seek guidance from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 1/5 Palmitoyl Sh-Tripeptide-2 Amide is considered very low on the pore-clogging scale because it is used at tiny concentrations, is water soluble and the attached palmitic acid is bound within a large peptide that does not behave like free fatty acids. Laboratory and anecdotal evidence show it rarely triggers comedones or blackheads. This makes it generally suitable for people who are prone to acne and breakouts. As always overall formula design matters, so a product packed with heavy oils or waxes could still cause congestion even if this peptide itself is non-problematic.
The comedogenic potential of peptides is not well studied in isolation, but their large molecular size and low oil content typically keep them from settling into and blocking follicles.
Summary
Palmitoyl Sh-Tripeptide-2 Amide acts as a humectant, skin conditioning and skin protecting agent. It draws moisture toward the surface for a plumper look, smooths and softens rough texture by supporting the skin barrier and leaves a light protective film that helps defend against environmental stress. Although not as famous as peptides like Matrixyl it is gaining traction in targeted firming serums and eye creams because of its stability and gentle profile.
Safety data and user reports point to low irritation risk with no evidence of hormonal or systemic effects at cosmetic levels, so most people can use it with confidence. Still, every skin is unique which is why a quick patch test is a smart step before adding any new product that contains this peptide.