What Is Palmitoyl Tripeptide-36?
Palmitoyl Tripeptide-36 is a small chain of three amino acids that has been linked to palmitic acid, a fatty acid found in plants and animals. Joining the peptide to a fatty acid makes it easier for the ingredient to blend with skin’s natural oils and reach the surface layers where it can do its job. The peptide part is designed to signal skin cells to behave in a younger, healthier way while the palmitic acid part helps it stay stable and penetrate better.
This ingredient grew out of the search for gentler options to support skin firmness and smoothness without the heaviness of some older oils or waxes. Peptide research expanded in the late 1990s and early 2000s, leading labs to attach fatty acids to short peptides to improve delivery. Palmitoyl Tripeptide-36 is one of the results of that work and it started appearing in premium skin care lines in the last decade.
Manufacturers make Palmitoyl Tripeptide-36 in a lab through solid-phase peptide synthesis. They build the three amino acids in the right order, then react the finished peptide with palmitic acid to form a stable bond. After purification and testing, the ingredient is ready to add to cosmetic formulas.
You will most often spot Palmitoyl Tripeptide-36 in lightweight serums, eye creams, night creams, sheet masks, anti aging moisturizers, spot treatments and leave-on masks that aim to improve tone and texture.
Palmitoyl Tripeptide-36’s Cosmetic Benefits/Uses
This peptide is prized for its ability to support skin softness and resilience.
As a skin conditioning agent, Palmitoyl Tripeptide-36 helps skin feel smoother and look more even by encouraging healthy cell activity and supporting the skin barrier. Formulas that include it can feel more hydrating, promote a plumper appearance and reduce the look of fine lines over time.
Who Can Use Palmitoyl Tripeptide-36
This peptide is generally suitable for all skin types, including dry, oily, combination and sensitive skin, because it is lightweight and non-greasy. Those with very reactive or compromised skin should still introduce it slowly since any new active can cause unexpected irritation.
The ingredient is made synthetically and contains no animal-derived components, so it is considered vegan and vegetarian friendly. Always check the full product label because other ingredients in the formula might not meet those standards.
Current safety data do not flag Palmitoyl Tripeptide-36 as a problem for pregnant or breastfeeding women when used topically in cosmetic amounts. This is not medical advice and anyone who is expecting or nursing should discuss new skincare products with a qualified doctor just to be safe.
Palmitoyl Tripeptide-36 is not known to increase photosensitivity, so it can be used morning or night. Standard daytime sun protection is still recommended to protect skin health.
Potential Side Effects/Adverse Reactions
Individual responses to Palmitoyl Tripeptide-36 vary. The effects below are possible yet uncommon when the ingredient is formulated and used as intended.
- Mild redness or warmth
- Temporary stinging or tingling
- Itchiness
- Dry patches if combined with strong exfoliants
- Allergic contact dermatitis in those sensitive to peptides or fatty acids
If any of these reactions occur discontinue use and consult a healthcare professional.
Comedogenic Rating
Rating: 1 out of 5
Palmitoyl Tripeptide-36 is a lightweight peptide joined to palmitic acid purely for delivery, not to create an oily film. It sits on skin without clogging pores and is used at very low percentages, which keeps its pore-blocking potential minimal. The palmitic acid portion is present in such a small amount that it rarely causes congestion.
Suitable for acne-prone or breakout-prone skin.
Formulas that pair this peptide with heavy butters or waxes can raise the overall comedogenicity, so always look at the full ingredient list.
Summary
Palmitoyl Tripeptide-36 conditions skin by signaling cells to act younger, helping boost collagen support, smooth fine lines, improve elasticity and strengthen the moisture barrier. The attached palmitic acid keeps the peptide stable and helps it slip through the skin’s oily surface so it can get to work.
It has a modest but growing fan base, mostly in mid to high-end serums and eye creams, and is gaining attention as brands look for gentle peptide options beyond the big-name players.
Current research and cosmetic use show it to be safe for most people with a very low risk of irritation or pore clogging. As with any new skincare ingredient, try a small patch first to be on the safe side.