What Is Pantothenoyl Dipeptide-13?
Pantothenoyl Dipeptide-13 is a lab-made compound formed when pantothenic acid, also known as vitamin B5, is linked to a short two-amino-acid chain called Dipeptide-13. Joining the vitamin with the peptide gives the final material a small size that can sit comfortably on skin and helps it stay stable in a water-based formula.
The idea of pairing vitamins with peptides gained ground in the early 2000s as brands looked for ways to boost skin care results without turning to heavy oils or strong actives. Pantothenic acid was already loved for its soothing feel so chemists connected it to a peptide that could improve skin’s surface. The result was Pantothenoyl Dipeptide-13 a gentle ingredient that could be added to daily products.
Creating it starts with purified pantothenic acid and a lab-synthesized Dipeptide-13. Through a controlled reaction called peptide coupling the two parts are bonded. The finished ingredient is then filtered and dried into a fine powder that easily dissolves in water or light gels.
Because it is mild and water-friendly Pantothenoyl Dipeptide-13 shows up in many leave-on products. You will spot it in lightweight moisturizers, anti-aging serums, sheet masks, under-eye creams and after-sun gels where brands want a soft conditioning effect without clogging pores.
Pantothenoyl Dipeptide-13’s Cosmetic Benefits/Uses
Pantothenoyl Dipeptide-13 is mainly valued for the comfortable feel it gives to skin and for the way it helps formulas glide on smoothly.
- Skin conditioning: It softens skin surface helps maintain a healthy moisture level and can reduce the rough or tight feeling that sometimes follows cleansing. Formulators use it to leave skin feeling supple and refreshed which can make a product feel more luxurious and boost user satisfaction.
Who Can Use Pantothenoyl Dipeptide-13
Pantothenoyl Dipeptide-13 is generally considered suitable for every skin type including dry, oily, combination and sensitive skin because it is water based and non greasy. Its lightweight texture will not weigh down oily or acne prone skin and its gentle nature makes it comfortable for easily irritated complexions. At this time there are no specific skin types that should avoid it unless an individual has a known allergy to vitamin B5 derivatives or peptides.
The ingredient is produced synthetically with no animal derived raw materials so it is normally appropriate for vegans and vegetarians. As always it is wise to verify the finished product’s full ingredient list and the brand’s sourcing policy if strict vegan standards are required.
No safety warnings single out Pantothenoyl Dipeptide-13 for pregnancy or breastfeeding. In theory its mild profile makes it low risk however this is not medical advice and anyone who is pregnant or nursing should review any skincare product with their doctor to be sure it suits their personal needs.
Pantothenoyl Dipeptide-13 does not increase photosensitivity so it can be used day or night without raising the skin’s vulnerability to sunburn. Normal daily sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Pantothenoyl Dipeptide-13 can vary from person to person. The points below list potential issues yet they are uncommon when the ingredient is used correctly and most users will experience none of them.
- Mild redness or warmth shortly after application
- Temporary stinging or tingling on very sensitive skin
- Localized itching or dryness if combined with other strong actives
- Allergic contact dermatitis in people with a peptide or vitamin B5 allergy
If any of these reactions occur discontinue use and consult a healthcare professional for tailored advice.
Comedogenic Rating
Rating: 0 / 5
Pantothenoyl Dipeptide-13 is water soluble and contains no fatty acids or heavy waxes that could block pores. Its peptide structure sits lightly on skin and rinses off easily so it is classed as non comedogenic.
This makes it suitable for people who are prone to acne or frequent breakouts.
Keep in mind that the finished product’s overall formula can raise the pore clogging potential even when this ingredient itself scores a zero.
Summary
Pantothenoyl Dipeptide-13 conditions skin by pairing vitamin B5 with a short peptide that can attract and hold water on the surface. The result is a smoother feel and improved softness without leaving a greasy film.
It is still a niche ingredient so you will see it pop up in select serums eye gels and light moisturizers rather than across whole product lines. Brands that focus on gentle yet modern actives tend to feature it the most.
Current safety data shows a very low risk profile with irritation or allergy occurring only in rare cases. As with any new skincare step patch testing on a small area for a few days is a smart way to confirm personal tolerance.