Polyglyceryl-10 Pentaisostearate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyglyceryl-10 Pentaisostearate?

Polyglyceryl-10 Pentaisostearate is a plant-derived ingredient made by joining ten glycerin units with five molecules of isostearic acid, a fatty acid usually sourced from vegetable oils like rapeseed or soybean. The result is a mild, oil-loving compound that blends smoothly with both water and oil. Chemists began exploring polyglyceryl esters in the 1990s as a gentler alternative to traditional surfactants, and this specific version gained popularity once formulators noticed its ability to create stable, creamy textures without added irritation. Production starts with glycerin that is heated and condensed to form decaglycerol, which is then reacted with purified isostearic acid under controlled temperatures to form the pentaester. You will often spot Polyglyceryl-10 Pentaisostearate in makeup removers, cleansing balms, facial oils, nourishing masks, tinted moisturizers and baby care products where a soft, cushiony feel is key.

Polyglyceryl-10 Pentaisostearate’s Cosmetic Benefits/Uses

This ingredient earns its place on labels thanks to the roles below

  • Emollient: Smooths rough patches, softens skin and leaves a light protective film that reduces moisture loss for a silky after-feel
  • Emulsifying: Helps water and oil mix, creating stable creams and lotions that resist separation and deliver an even spread of active ingredients

Who Can Use Polyglyceryl-10 Pentaisostearate

Thanks to its light, cushiony feel, Polyglyceryl-10 Pentaisostearate suits most skin types including dry, normal, combination and even sensitive skin because it is free of harsh detergents and common allergens. Very oily or acne-prone users can usually tolerate it too, though they may prefer lower percentages since any fatty ingredient can feel heavy if overused.

The compound is made from plant glycerin and plant-derived isostearic acid, so it is suitable for vegans and vegetarians. No animal by-products or animal testing are required to produce the raw material.

Current safety data shows no special risks for pregnant or breastfeeding women when the ingredient is used topically in cosmetic amounts. This is not medical advice and anyone who is expecting or nursing should check with a healthcare professional before adding new products to their routine.

The ingredient does not increase photosensitivity, meaning it will not make skin more prone to sunburn, yet daily sunscreen is still recommended as part of good skincare habits.

Potential Side Effects/Adverse Reactions

Reactions to topical Polyglyceryl-10 Pentaisostearate vary from person to person. The points below outline potential issues, though most people will not experience them when the ingredient is formulated and used correctly.

  • Mild skin redness or itching in those with a specific sensitivity to fatty acid esters
  • Temporary stinging if applied to broken or freshly exfoliated skin
  • Rare allergic contact dermatitis in individuals with pre-existing allergies to similar compounds
  • Slight eye irritation if the product accidentally gets into the eyes
  • Possible pore congestion for users who are extremely acne-prone when the ingredient is present at high levels in rich formulas

If any discomfort, rash or swelling develops stop using the product and consult a healthcare professional.

Comedogenic Rating

Comedogenic rating: 1/5. Polyglyceryl-10 Pentaisostearate is a large, branched molecule that spreads easily without sinking deeply into pores which keeps the likelihood of clogging low. It also has a high proportion of hydrophilic glycerin units that balance the fatty parts so residue rinses away more readily than with pure oils. Formulas that keep the concentration moderate tend to feel light and leave minimal oily film. Because of this the ingredient is generally acceptable for acne-prone or breakout-prone skin, though individual tolerance always varies. Heavier balms packed with additional rich oils may tip the scale, so product format matters more than the raw material itself.

Summary

Polyglyceryl-10 Pentaisostearate works mainly as an emollient and an emulsifier. Its glycerin backbone attracts a touch of water while its isostearic acid chains love oil, letting it bridge the two phases so creams stay smooth and stable. On skin those fatty chains glide over rough areas to soften and seal in moisture, creating the cushiony afterfeel people enjoy. Although not yet a household name it is quietly popular among formulators who want plant-based, gentle alternatives to traditional surfactants, especially in cleansing balms and baby care products.

Current research and global regulatory reviews rate it as a low-risk ingredient with minimal irritation potential. Still, skin is personal and formulas differ so it is wise to do a quick patch test when trying any new product that contains Polyglyceryl-10 Pentaisostearate just to be safe.

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