Polyglyceryl-15 Diisostearate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyglyceryl-15 Diisostearate?

Polyglyceryl-15 Diisostearate is a plant-derived ingredient created by linking fifteen glycerin molecules together then attaching two molecules of isostearic acid, a fatty acid commonly sourced from vegetable oils. The result is a lightweight, waxy liquid that marries the water-loving nature of glycerin with the oil-loving character of isostearic acid, giving it a balanced affinity for both water and oils. First explored in the 1990s as brands looked for alternatives to traditional surfactants, it gained popularity when formulators wanted milder, more biodegradable options that could still cleanse and condition effectively.

Production starts with food-grade glycerin that is heated under controlled conditions to form a polyglycerin chain. Isostearic acid is then esterified onto the chain, creating the final diester. Because the raw materials come from renewable plant sources and the process avoids harsh solvents, Polyglyceryl-15 Diisostearate is often highlighted in “clean beauty” lines.

You’ll most often see it in facial cleansers, micellar waters, makeup removers, creamy body washes, moisturizing shampoos, leave-in hair conditioners and multipurpose balms. Its gentle profile also makes it suitable for baby care and sensitive-skin formulas.

Polyglyceryl-15 Diisostearate’s Cosmetic Benefits/Uses

This versatile ingredient brings several practical benefits to modern formulations:

  • Cleansing – acts as a mild surfactant that lifts away dirt, oil and makeup without stripping the skin or hair’s natural moisture, leaving a soft after-feel instead of the squeaky sensation harsher cleansers can cause
  • Hair conditioning – deposits a thin, flexible film along the hair shaft that smooths cuticles, reduces static and improves comb-through, helping hair feel softer and look shinier

Who Can Use Polyglyceryl-15 Diisostearate

Thanks to its gentle cleansing action and lightweight emollient feel, Polyglyceryl-15 Diisostearate suits nearly every skin type—including dry, normal, combination and sensitive skin—because it removes grime without upsetting the skin’s natural barrier. Oily or acne-prone users usually tolerate it well too, since the molecule is large and unlikely to clog pores, though individual responses can vary.

The ingredient is manufactured from plant-derived glycerin and fatty acids so it aligns with vegan and vegetarian lifestyles and is free of animal-derived by-products or testing.

No data suggest that Polyglyceryl-15 Diisostearate poses a risk during pregnancy or while breastfeeding when used in rinse-off or leave-on cosmetics. This is not medical advice; anyone who is pregnant or nursing should review all personal-care products with a healthcare professional to be extra sure.

It does not heighten photosensitivity, meaning it will not make skin more prone to sunburn. It also plays nicely with most other common skincare ingredients, including acids, retinoids and sunscreens, so formulating conflicts are rare.

Potential Side Effects/Adverse Reactions

Reactions to topical Polyglyceryl-15 Diisostearate differ from person to person. The issues listed below are uncommon and most users will not notice any problems when the ingredient is used correctly in a well-formulated product.

  • Mild skin irritation in people who are extremely sensitive to surfactants or fatty acid esters
  • Contact allergy presenting as redness itching or small bumps if an individual is allergic to glycerin derivatives or isostearic acid
  • Eye stinging when the pure ingredient or a high-level formula accidentally gets into the eyes
  • Greasy feel or buildup on very fine hair if used in leave-in conditioners at high levels
  • Rare acne-like breakouts in users who react to any occlusive film on the skin

If you experience discomfort persistent redness swelling or breakouts while using a product containing Polyglyceryl-15 Diisostearate stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 1 out of 5. Polyglyceryl-15 Diisostearate is built on a bulky polyglycerin backbone that keeps the molecule sitting on the skin surface rather than slipping into pores. The two isostearic acid chains add some richness but are ester-linked, which makes them less likely to act like free fatty acids that can clog pores. Most lab and user reports show little to no pore-clogging activity.

Given this low score, products using normal levels of Polyglyceryl-15 Diisostearate are generally fine for acne-prone or breakout-prone users.

Remember that overall formula, concentration and personal skin chemistry also affect whether a product will trigger pimples, so the full ingredient list still matters.

Summary

Polyglyceryl-15 Diisostearate works as a gentle cleanser and light hair conditioner. Its polyglycerin portion binds water while the isostearic acid side loves oil, letting it lift away grime and leave behind a soft flexible film that smooths hair and skin.

It shows up most often in micellar waters makeup removers creamy body washes and mild shampoos, especially in clean beauty lines, but it is still less common than older surfactants so you may not see it on every store shelf.

Safety data and real-world use point to a very low risk of irritation or pore clogging for most people. Still, anyone trying a new product that contains this ingredient should do a quick patch test to make sure their skin agrees with it.

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