What Is Polyglyceryl-2 Isopalmitate?
Polyglyceryl-2 Isopalmitate is a plant-derived ingredient created by linking two glycerin molecules and then attaching them to isopalmitic acid, a fatty acid that can be sourced from palm or coconut oil. Chemically it is known as 1,2,3-propanetriol homopolymer isohexadecanoates, which simply describes its glycerin backbone and fatty acid side chains. The idea of joining glycerin and fatty acids is not new; soap makers have relied on similar chemistry for centuries. Modern cosmetic chemists refined the process in the 1990s to produce gentler, PEG-free emulsifiers, leading to the commercial use of the polyglyceryl family in creams and lotions.
Manufacturing starts with glycerin undergoing controlled heating to form short chains called polyglycerols. These chains are then reacted with isopalmitic acid in the presence of a food-grade catalyst. The result is a mild, biodegradable substance that balances water and oil without the need for harsher synthetic surfactants.
Because it is an effective yet gentle emulsifier, you will find Polyglyceryl-2 Isopalmitate in moisturizers, facial masks, anti-aging serums, makeup removers, lipsticks and sunscreens. Brands favor it for clean beauty and sensitive-skin formulas where PEGs or traditional soaps are avoided.
Polyglyceryl-2 Isopalmitate’s Cosmetic Benefits/Uses
This ingredient plays one key role in cosmetic formulas.
As an emulsifying agent Polyglyceryl-2 Isopalmitate helps oil and water stay blended, creating stable lotions and creams that feel smooth and non-greasy on the skin. Its mild nature supports sensitive-skin products, and its plant origin aligns with vegan and eco-friendly claims while still delivering the silky texture consumers expect.
Who Can Use Polyglyceryl-2 Isopalmitate
This emulsifier is considered gentle enough for all skin types, including dry, oily, sensitive and combination skin, because it has a mild fatty-acid structure that mimics the skin’s own lipids. It does not clog pores or leave a heavy residue, so acne-prone users usually tolerate it well. No specific skin type is advised to avoid it unless a rare personal allergy to coconut or palm-derived ingredients exists.
Polyglyceryl-2 Isopalmitate is plant sourced and contains no animal-derived substances, making it suitable for vegans and vegetarians. Production relies on vegetable glycerin and fatty acids obtained from sustainable palm or coconut oil, so it aligns with most clean beauty standards.
Current safety data show no reproductive or developmental concerns, so products with this ingredient are generally viewed as safe for pregnant or breastfeeding women when used as directed. This is not medical advice; anyone who is pregnant or nursing should check with a healthcare professional before adding new skincare products.
The molecule is not photosensitizing and does not increase the skin’s sensitivity to sunlight. It is also free of known hormonal mimics, gluten and common fragrance allergens, which makes it a low-risk choice for people with multiple sensitivities.
Potential Side Effects/Adverse Reactions
Responses to topical Polyglyceryl-2 Isopalmitate differ from person to person. The following points list potential side effects, though most users will not experience them if the ingredient has been properly formulated and used as intended.
- Mild redness or irritation in individuals with an existing sensitivity to fatty acid esters
- Contact dermatitis in the rare case of an allergy to coconut or palm derivatives
- Eye stinging when used in high concentrations around the delicate eye area
If any discomfort or unexpected reaction occurs discontinue use and consult a healthcare professional.
Comedogenic Rating
Rating: 1 / 5
Polyglyceryl-2 Isopalmitate is a lightweight fatty acid ester that sits on the skin without forming a heavy occlusive film, and its polyglycerin backbone boosts water solubility which helps it rinse away more easily than pure oils. Most published ingredient databases list similar polyglyceryl esters at 0 – 1, and consumer feedback rarely links it to clogged pores. Because of this low score it is generally considered suitable for acne-prone or breakout-prone skin.
Formulas that pair it with highly comedogenic carrier oils could still trigger congestion, so the overall product composition matters more than the presence of this single emulsifier.
Summary
Polyglyceryl-2 Isopalmitate is a plant-derived emulsifier that keeps oil and water phases blended, giving lotions and creams a smooth stable texture while avoiding harsher PEG-based surfactants. It is popular in clean beauty and sensitive-skin launches yet still under the radar compared with long-standing emulsifiers like cetearyl alcohol so you may not see it on every label.
Available safety data show it to be low risk for irritation sensitization or hormonal activity, and its comedogenic rating of 1 means most users can enjoy it without worrying about breakouts. As with any new cosmetic ingredient it is wise to patch test a fresh product before full-face application just to be safe.