Polyglyceryl-2 Sesquicaprylate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyglyceryl-2 Sesquicaprylate?

Polyglyceryl-2 Sesquicaprylate is a plant derived ingredient made by joining small units of glycerin called diglycerol with caprylic acid a fatty acid that comes from coconut or palm oil. The result is a mixture of mono and diesters that appears as a clear to pale yellow liquid.

The idea behind this material grew out of the skincare industry’s search for gentle alternatives to petroleum based emulsifiers in the early 2000s. Chemists found that linking glycerin which loves water to caprylic acid which loves oil created a substance that could keep the two phases blended without the need for stronger synthetic helpers. Over the past decade brands focused on clean beauty have adopted it widely because it is biodegradable and free from ethylene oxide or PEG groups.

To make Polyglyceryl-2 Sesquicaprylate manufacturers heat diglycerol with purified caprylic acid in the presence of a food grade catalyst then remove excess water under vacuum. The finished liquid is filtered tested for purity and delivered to cosmetic labs.

You will most often see this ingredient in moisturizers face masks lotions sunscreens creamy cleansers makeup removers and light hair conditioners where a smooth stable texture is needed.

Polyglyceryl-2 Sesquicaprylate’s Cosmetic Benefits/Uses

In formulas this multitasker mainly works as an emulsifier.

As an emulsifier it helps water and oil stay mixed so the product feels uniform from the first pump to the last. A stable emulsion spreads evenly on the skin absorbs better and is less likely to separate in the jar which means a longer shelf life and a more pleasant user experience.

Who Can Use Polyglyceryl-2 Sesquicaprylate

This ingredient is considered friendly for all skin types including dry, oily, combination and sensitive skin because it is lightweight, non greasy and has a very low irritation profile. Individuals with highly reactive or allergy-prone skin generally tolerate it well since it contains no fragrances or common sensitizers. There are currently no skin types that need to avoid it specifically though anyone with a known coconut or palm fatty acid allergy should read labels carefully because caprylic acid is sourced from those plants.

Polyglyceryl-2 Sesquicaprylate is produced from vegetable glycerin and plant-derived caprylic acid so it is suitable for vegans and vegetarians. No animal by-products or animal testing are required to manufacture the raw material.

Expectant or breastfeeding women can usually use products containing this emulsifier because it stays on the surface of the skin and is not known to penetrate deeply or act hormonally. This is not medical advice and anyone who is pregnant or nursing should discuss all skincare products with a qualified healthcare provider to be extra safe.

The ingredient does not make skin more sensitive to sunlight and it has no known interactions with UV exposure. It also plays well with most active ingredients such as vitamin C, niacinamide and retinoids so formulators add it freely without stability issues.

Potential Side Effects/Adverse Reactions

Side effects from topical Polyglyceryl-2 Sesquicaprylate can vary from person to person. The following list covers potential reactions although they are uncommon when the ingredient is used correctly in a finished product.

  • Mild redness or stinging mostly in individuals with highly compromised skin barriers
  • Contact dermatitis in rare cases where a person is allergic to coconut or palm derivatives
  • Eye irritation if a product containing it accidentally gets into the eyes, usually temporary and relieved by rinsing with water

If any irritation or unexpected reaction occurs stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 1 out of 5. Polyglyceryl-2 Sesquicaprylate is a lightweight emulsifier with a structure that does not create a heavy film on the skin, so pores are unlikely to get blocked. It contains short chain caprylic fatty acids that rinse away or absorb without leaving a waxy residue, which keeps the comedogenic potential very low.

This makes the ingredient generally suitable for people who are prone to acne or breakouts. Most users can enjoy formulas containing it without worrying about clogged pores.

Because the finished product can also include other ingredients that may raise the overall comedogenic load, always look at the full ingredient list if pore congestion is a concern.

Summary

Polyglyceryl-2 Sesquicaprylate’s main job is to keep water and oil smoothly blended in lotions, creams and cleansers. It does this thanks to its dual nature: the glycerin part loves water while the caprylic part loves oil, so it positions itself between the two phases and locks them together for a stable, silky texture.

Its plant origin, biodegradability and PEG-free profile have made it a favorite in clean beauty lines, though it is still less common than long-standing synthetic emulsifiers. As more brands focus on gentle, eco-minded formulas its usage continues to grow.

Current data shows it is very safe with a low risk of irritation or pore blockage, so most skin types can use it confidently. As with any new skincare ingredient it is wise to patch test a fresh product first to be certain your skin agrees with it.

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