Polyglyceryl-2 Triisostearate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyglyceryl-2 Triisostearate?

Polyglyceryl-2 Triisostearate is a plant-derived ingredient created by linking two glycerin molecules and bonding them with three isostearic acid chains that come from vegetable fats. This blend of water-loving glycerin and oil-loving fatty acids makes it an effective bridge between oil and water. The process starts with glycerin, a by-product of natural oils, which is heated so the molecules join together into a short chain called polyglycerin. Isostearic acid is then attached through a reaction known as esterification. Chemists perfected this method in the late 1990s when the beauty industry sought gentler alternatives to petroleum-based emulsifiers. Today the ingredient shows up in many makeup removers, cleansing balms, cream foundations, lipsticks, sunscreens, tinted moisturizers and rich night creams because it helps combine oily and watery parts into a smooth stable product.

Polyglyceryl-2 Triisostearate’s Cosmetic Benefits/Uses

This ingredient acts as an emulsifier. It binds water and oil together so lotions stay creamy and makeup removers rinse off without a greasy film. By improving how well a formula holds itself, it keeps the texture even over time and lets active ingredients spread more evenly on the skin.

Who Can Use Polyglyceryl-2 Triisostearate

Because it is lightweight and gentle it suits most skin types including dry, normal, combination and oily. Its fatty acid portion adds a touch of softness without leaving heavy residue so even sensitive or reactive skin generally tolerates it well. Extremely acne-prone users may prefer to check the full formula to ensure richer oils are not present in high amounts but the ingredient itself is not known to clog pores.

Polyglyceryl-2 Triisostearate is sourced from plant glycerin and vegetable-based isostearic acid, making it appropriate for vegans and vegetarians who want to avoid animal-derived emulsifiers.

Current safety data shows no specific risks for pregnant or breastfeeding women when the ingredient is used topically in cosmetics. It is largely inert on the skin and does not penetrate deeply. This is not medical advice so anyone who is pregnant or nursing should run any skincare product past a qualified health professional to be on the safe side.

The ingredient does not make skin more sensitive to sunlight and can be worn morning or night without increasing the chance of sunburn. It remains stable across a wide pH range and pairs well with most other cosmetic actives, which helps minimize formulation conflicts.

Potential Side Effects/Adverse Reactions

Side effects from topical Polyglyceryl-2 Triisostearate vary from person to person. The points below list potential reactions but they are not likely to occur for the average user when the ingredient is properly formulated.

  • Mild redness or irritation on very sensitive skin
  • Rare contact allergy presenting as itching or rash
  • Possible breakouts if the overall product is heavy and left on oily skin
  • Transient stinging when applied to broken or freshly exfoliated skin
  • Enhanced penetration of strong actives in the same formula, which could amplify their side effects

If you experience any of these reactions stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 1/5 (low)

Polyglyceryl-2 Triisostearate scores a 1 because its bulky ester structure sits mainly on the skin surface and is easily removed with normal cleansing. The isostearic acid portion is branched rather than straight chained which further reduces its pore-blocking tendency. Most lab and consumer reports do not link it to consistent clogging even in oily skin formulas.

Suitable for people who are prone to acne or breakouts, provided the overall product is light and non-occlusive.

Keep in mind that a low rating applies to the ingredient itself. If it appears alongside heavier waxes or butters the finished product could still feel rich for very oily skin types.

Summary

Polyglyceryl-2 Triisostearate is a plant-derived emulsifier that joins water and oil so creams, cleansers and makeup stay smooth and stable. It does this by combining glycerin-based segments that love water with fatty segments that love oil, creating a bridge that locks the two together.

Thanks to its gentle origin and reliable performance it shows up in an increasing number of mainstream and indie skincare ranges, especially cleansing balms and creamy makeup where a soft, cushiony feel is desired.

Current safety reviews find it non-irritating, low risk and appropriate for most users, including sensitive skin. As with any new cosmetic it is wise to perform a quick patch test to rule out individual sensitivities before full use.

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