Polyglyceryl-6 Isostearate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyglyceryl-6 Isostearate?

Polyglyceryl-6 Isostearate is a plant-derived ingredient created by linking six glycerin molecules and then attaching them to isostearic acid, a fatty acid that often comes from vegetable oils such as coconut or soybean. The result is a mild, oil-loving compound that mixes well with water. This ingredient first gained attention in the 1990s when formulators wanted alternatives to petroleum-based emulsifiers that could meet the growing demand for “green” beauty products. It is produced through a straightforward two-step process: glycerin molecules are polymerized under controlled heat, then the resulting polyglycerin is reacted with isostearic acid to form the final ester.

Because it bridges oil and water so effectively, Polyglyceryl-6 Isostearate shows up in a wide range of products. You will often see it in lightweight facial moisturizers, creamy cleansing balms, sheet mask essences, makeup removers, tinted sunscreens, anti-aging serums and even solid stick products where a smooth, stable texture is essential.

Polyglyceryl-6 Isostearate’s Cosmetic Benefits/Uses

This ingredient serves one main function in cosmetics: it is an emulsifier. By keeping oil and water phases blended, it gives products a pleasing, uniform texture that feels comfortable on the skin, prevents watery separation on the shelf and helps active ingredients spread evenly for consistent results.

Who Can Use Polyglyceryl-6 Isostearate

Thanks to its gentle nature Polyglyceryl-6 Isostearate suits nearly every skin type including dry, normal, combination oily and even sensitive skin. It adds slip without leaving a greasy film so oily or acne prone users typically tolerate it well while its mildness makes it friendly for easily irritated complexions. There are no known skin types that must avoid it unless a rare personal sensitivity exists.

The ingredient is synthesized from plant based glycerin and vegetable derived isostearic acid with no animal by-products involved which makes it suitable for vegans and vegetarians.

No data suggest that Polyglyceryl-6 Isostearate poses a risk to pregnant or breastfeeding women however this information is not medical advice. Anyone who is expecting or nursing should review all skincare choices with a qualified healthcare provider to be extra cautious.

Polyglyceryl-6 Isostearate does not increase photosensitivity so daytime use poses no added sun-related risk. It is also odorless and free of common allergens like gluten and soy which broadens its versatility in hypoallergenic formulas.

Potential Side Effects/Adverse Reactions

Individual responses to topical ingredients can differ. The effects listed below are only potential reactions and most users will not experience them when the ingredient is used properly by a reputable manufacturer.

  • Mild skin irritation such as redness stinging or itching
  • Allergic contact dermatitis in people with a specific sensitivity to fatty acid esters
  • Temporary eye irritation or watering if the product accidentally gets into the eyes
  • Blocked pores or breakouts in very acne prone skin if the overall formula is heavy

If any unwanted reaction occurs stop using the product and consult a healthcare professional for guidance.

Comedogenic Rating

Rating: 1 out of 5. Polyglyceryl-6 Isostearate is made from lightweight glycerin units joined to a branched fatty acid, creating a molecule that rinses clean and does not linger in pores. It helps oils and water blend rather than sitting on the skin surface like richer butters or waxes, so it rarely traps debris or sebum. This low score means most acne prone users can use products containing it without added worry, though the overall formula still matters. Its large molecular size and quick skin feel further reduce the chance of clogging.

Worth noting: in very heavy balms or waterless sticks where multiple occlusive oils are present, breakouts may come from those richer ingredients rather than from Polyglyceryl-6 Isostearate itself.

Summary

Polyglyceryl-6 Isostearate is primarily an emulsifier that keeps water and oil phases blended, giving creams, lotions and cleansing balms their smooth texture, stability and even spread. It does this by anchoring its water loving glycerin chain to its oil loving isostearic tail, reducing surface tension so the two phases stay unified over time.

While not a headline ingredient like hyaluronic acid or retinol, it is quietly popular among formulators who want plant based, PEG free options especially in clean beauty lines. Its gentle profile makes it a go to for sensitive skin products as well as lightweight daytime moisturizers.

Safety data show a very low irritation and allergy risk, and regulatory bodies worldwide allow its use without strict limits. As with any new skincare ingredient it is smart to patch test a fresh product to ensure personal compatibility.

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