Polyoxymethylene Glycol Urea: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyoxymethylene Glycol Urea?

Polyoxymethylene Glycol Urea is a synthetic polymer that forms when urea, formaldehyde and a glycol such as ethylene glycol are reacted together under carefully controlled heat and pH conditions. The result is a water-soluble chainlike molecule that can slowly break down to release small amounts of formaldehyde. That built-in ability to give off preservative agents is the main reason this ingredient finds its way into cosmetics.

The link between urea and formaldehyde chemistry dates back to the 1930s, when chemists were looking for safer, longer-lasting ways to keep personal care products from spoiling. Over time they discovered that adding a glycol to the reaction improved stability and solubility, giving rise to Polyoxymethylene Glycol Urea. By the late twentieth century it was being used in lotions and creams as an alternative to harsher standalone preservatives.

Manufacturing starts with combining urea and formaldehyde in water, then adding glycol. The mixture is heated so the molecules join together step by step into a larger polymer. Once the desired molecular weight is reached the batch is neutralised, cooled and purified, leaving a clear to slightly hazy liquid or powder that blends easily into water-based formulas.

You are most likely to find Polyoxymethylene Glycol Urea in everyday products such as face moisturisers, sheet masks, hand creams, body lotions, hair conditioners and some rinse-off cleansers. Brands choose it when they want reliable preservation without the strong odour or sensitising potential of free formaldehyde.

Polyoxymethylene Glycol Urea’s Cosmetic Benefits/Uses

In cosmetics this ingredient serves one main purpose that directly benefits both the product and the user.

As a preservative Polyoxymethylene Glycol Urea keeps creams, lotions and gels free from mold, yeast and bacteria for the entire time they sit on a shelf or in your bathroom. A well-preserved formula stays safe to apply, keeps its texture and colour and reduces the risk of skin irritation that can develop when microbes grow unchecked.

Who Can Use Polyoxymethylene Glycol Urea

Because it is a mild preservative used at very low levels Polyoxymethylene Glycol Urea is generally considered suitable for all skin types including oily, dry, combination and sensitive. People with extremely reactive or formallydehyde-allergic skin may still want to choose formulas that rely on alternative preservation since the polymer does release trace amounts of formaldehyde while it works.

The ingredient is synthetic and contains no animal-derived materials so it is acceptable for both vegans and vegetarians.

Current safety assessments have not flagged any specific risks for pregnant or breastfeeding women when the ingredient is used as directed in a finished cosmetic product. This text is not medical advice and anyone who is pregnant or nursing should show their skincare routine to a qualified health professional to be sure it meets their individual needs.

Polyoxymethylene Glycol Urea does not make skin more sensitive to sunlight and there are no known interactions with common active ingredients like vitamin C or retinol.

Potential Side Effects/Adverse Reactions

Responses to any cosmetic ingredient can differ from one person to another. The points below list potential but uncommon reactions that might occur with topical use of Polyoxymethylene Glycol Urea when it is part of a finished product. Most users will not notice any of these effects if the formula has been made correctly and used as intended.

• Mild redness or stinging on very sensitive skin

• Itchiness linked to formaldehyde allergy

• Watery eyes or nasal irritation when inhaled as a fine mist during spray application

If any irritation or discomfort develops stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 0/5

Polyoxymethylene Glycol Urea is water soluble, used at tiny preservative levels and lacks heavy oils or waxes, all of which means it is very unlikely to block pores or encourage blackheads. For acne prone or breakout prone skin this low rating makes the ingredient generally acceptable.

Because it breaks down into small water loving fragments rather than oily residues, no buildup is expected even with daily use. The only time a blemish response might occur is if the overall formula contains other comedogenic ingredients.

Summary

Polyoxymethylene Glycol Urea is a preservative that keeps cosmetics free from mold, yeast and bacteria by slowly releasing trace formaldehyde. It does this while staying gentle, water soluble and nearly undetectable in feel.

The ingredient enjoys steady but limited popularity; bigger brands often stick with more familiar names yet formulators who want a low odor alternative reach for it.

Current research shows it is safe for most users when used within regulated limits though anyone highly sensitive to formaldehyde should stay cautious. As with any new product it is wise to patch test first to make sure your skin agrees with the full formula.

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