Polyquaternium-80: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyquaternium-80?

Polyquaternium-80 is a synthetic polymer created by first crosslinking the plant derived surfactant lauryl glucoside with 1,3-dichloro-2-propanol, then converting the remaining chloropropanol groups into permanently charged quaternary ammonium sites using lauryldimethylamine. The result is a large, water soluble molecule that carries multiple positive charges along its backbone.

Although cationic polymers have been used in personal care since the 1960s, Polyquaternium-80 is a newer addition developed to give shampoos and conditioners stronger yet lighter conditioning without heavy buildup. Manufacturers were looking for a molecule that could cling to damaged hair, boost foam stability in cleansers and keep oil-and-water mixtures uniform. The crosslinking step gives the polymer a three-dimensional network while the quaternization locks in the positive charge, features that make it particularly effective in modern hair care.

The ingredient is produced in specialized reactors where lauryl glucoside and 1,3-dichloro-2-propanol are combined under controlled pH and temperature, followed by careful addition of lauryldimethylamine. After purification the polymer is supplied as an aqueous solution or as a concentrated paste ready to be blended into finished formulas.

You will most often spot Polyquaternium-80 in shampoos, rinse-off and leave-in conditioners, hair masks, styling creams, two-phase sprays and occasionally in skin cleansers where extra slip and mildness are desired.

Polyquaternium-80’s Cosmetic Benefits/Uses

Formulators turn to Polyquaternium-80 because it performs several useful jobs at once

  • Cleansing: The positive charges in the polymer help lift away negatively charged dirt and styling residue while keeping foam rich and stable, allowing shampoos and body washes to cleanse effectively yet feel gentle
  • Hair Conditioning: Its cationic sites are attracted to the damaged, negatively charged areas of hair fibers where the polymer forms a thin film that smooths cuticles, reduces static, improves wet-comb detangling and leaves hair softer and shinier without a heavy feel
  • Emulsifying: The amphiphilic nature of the crosslinked structure helps stabilize oil droplets in water based formulas, which keeps products like two-phase sprays, creamy masks and conditioning mousses uniform and visually appealing over their shelf life

Who Can Use Polyquaternium-80

Polyquaternium-80 is generally considered friendly for all skin and hair types. Its film-forming action is light enough for fine or oily hair yet still adds noticeable softness to coarse or chemically treated strands. On skin, the polymer has a low irritation profile so even those who label themselves as sensitive usually tolerate it well. People with a known sensitivity to cationic polymers, however, might prefer to avoid it since it could aggravate existing irritation.

The ingredient is produced from plant sourced lauryl glucoside and fully synthetic processing aids, with no animal by-products involved, so it is normally acceptable for vegans and vegetarians. As always it is wise to verify the finished product’s entire ingredient list and the brand’s manufacturing practices if strict cruelty-free or vegan standards are important to you.

No data suggest that Polyquaternium-80 poses a specific risk to women who are pregnant or breastfeeding when used in rinse-off or leave-on hair products. That said this information is not medical advice. Expectant or nursing mothers should run any new personal care product past their healthcare provider just to be safe.

The polymer does not cause photosensitivity, so it will not make skin or hair more vulnerable to sun damage. It is also free from common allergens like gluten, soy and nuts, making it a versatile choice for many formulating needs.

Potential Side Effects/Adverse Reactions

Individual responses to topical Polyquaternium-80 can vary. The effects listed below are possible yet uncommon if the ingredient is used at standard levels in properly formulated products.

  • Mild skin or scalp irritation in people who are sensitive to cationic polymers
  • Contact dermatitis presenting as redness, itching or small bumps in rare cases of true allergy
  • Eye stinging or watering if shampoo or conditioner accidentally runs into the eyes
  • leading to limp or dull strands when very high concentrations are used or products are not rinsed thoroughly

If any irritation or unexpected reaction occurs stop using the product immediately and seek professional medical advice.

Comedogenic Rating

Rating: 0 / 5 Polyquaternium-80 is a large, water-soluble, positively charged polymer that tends to stay on the surface of hair or rinse away with water rather than sink into facial pores. It contains no fatty acids or heavy oils that typically trigger clogged follicles, and it is almost always used in rinse-off hair care where skin contact is brief. Because of these characteristics it is considered non-comedogenic and is generally suitable for people who are prone to acne or breakouts. If used in a leave-on product the risk remains low thanks to its high solubility, though very heavy layering with other film-formers could, in theory, trap debris on the skin.

Summary

Polyquaternium-80 works as a three-in-one helper: it boosts cleansing by binding dirt and stabilising foam, it conditions hair by forming a light cationic film that smooths cuticles and fights static, and it acts as an emulsifier that keeps oil and water nicely blended in sprays, masks and creams. These benefits come from its crosslinked, permanently charged structure that lets it cling where needed yet rinse away cleanly.

The ingredient is a relative newcomer compared with older quaterniums so you will not see it in every shampoo aisle, but formulators who want lightweight conditioning without greasy feel are using it more each year.

Current safety data show low irritation potential and no comedogenicity, making Polyquaternium-80 a low-risk choice for most consumers. Still, skin is personal so it is always wise to patch test any new product containing this polymer before full use.

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