Polyquaternium-99: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Polyquaternium-99?

Polyquaternium-99 is a man-made polymer often described as a quaternary ammonium salt, created by linking together butyl methacrylate, 2-ethoxyethyl methacrylate and methacryloyloxyethyl trimethyl ammonium chloride. The result is a water-soluble chain that carries a positive charge, allowing it to cling to hair or skin surfaces that naturally carry a slight negative charge. Developed in the late twentieth century when cosmetic chemists were searching for longer-lasting conditioning agents, it quickly found a niche thanks to its ability to leave a smooth lightweight film. Production starts with the three liquid monomers, which are blended with an initiator and exposed to controlled heat or UV light so they join into a large repeating molecule. After purification and dilution the polymer arrives at manufacturers as a clear or slightly hazy liquid. You will spot Polyquaternium-99 in a wide range of products such as hair gels, setting sprays, leave-in conditioners, facial sheet masks, long-wear foundations, body lotions and many rinse-off cleansers that promise a soft touch or frizz control.

Polyquaternium-99’s Cosmetic Benefits/Uses

Polyquaternium-99 brings one key function to the table

Film forming: Once applied it creates an invisible flexible layer that helps lock in moisture smooth hair cuticles reduce flyaways improve spreadability of other actives and give makeup formulas better wear time without a heavy or sticky feel.

Who Can Use Polyquaternium-99

Polyquaternium-99 is generally well tolerated by all skin types including oily, dry and combination because its lightweight film allows skin to breathe while still adding softness. Even sensitive skin tends to handle the ingredient without trouble although anyone with a history of reactions to quaternary ammonium compounds should proceed with caution.

The polymer is fully synthetic and contains no animal derived components so it is suitable for both vegans and vegetarians. Its manufacture does not rely on animal by-products, making it a common choice for cruelty free formulas.

Current safety data shows no specific risks for women who are pregnant or breastfeeding since the large molecule is unlikely to penetrate deeply or enter the bloodstream. This is not medical advice and anyone who is expecting or nursing should run any skincare or haircare product past a doctor to be on the safe side.

Polyquaternium-99 is not known to cause photosensitivity and will not make skin more vulnerable to sunlight. Standard daytime sun protection habits are still recommended.

Potential Side Effects/Adverse Reactions

Side effects from topical use of Polyquaternium-99 vary from person to person. The points below list potential reactions that could occur yet they are uncommon when the ingredient is formulated correctly and used as directed.

  • Mild skin irritation such as redness or itching especially in highly sensitive users
  • Eye irritation or watering if the product accidentally gets into the eyes
  • Product build up on hair over time which can leave strands looking dull or weighed down
  • Rare cases of allergic contact dermatitis leading to rash or swelling
  • Possible interference with the absorption of leave-on actives if a very thick film forms

If any negative reaction occurs stop using the product immediately and consult a healthcare professional for advice.

Comedogenic Rating

Rating: 0–1 out of 5

Polyquaternium-99 is a large water-soluble polymer that does not sink into pores or leave an oily residue that could clog them. Its primary action is to sit on the surface as a thin, breathable film, so the risk of blocked pores is very low. Because of this, it is generally suitable for people who are prone to acne or breakouts. Since it rinses away easily and is not oil based, it is unlikely to contribute to blackheads or whiteheads. One thing to note is that heavy layering with other film formers could trap sweat or sebum, so keeping routines light will help maintain clear skin.

Summary

Polyquaternium-99 shines as a film former that smooths, conditions and boosts the wear time of haircare and makeup without feeling heavy. By carrying a gentle positive charge it bonds to the slightly negative surface of hair and skin, laying down a flexible veil that tames frizz, locks in light moisture and helps other ingredients spread evenly.

While not as famous as silicone derivatives or classic quats, it shows up in a steady stream of styling gels, leave-ins, primers and sheet masks because formulators value its clean finish and vegan profile. Safety reviews rate it as low risk for irritation, allergies or pore clogging, making it a dependable pick for most users. As with any new product, a quick patch test is smart before adding it to a regular routine, especially for sensitive skin.

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