Potato Sh-Polypeptide-11: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Potato Sh-Polypeptide-11?

Potato Sh-Polypeptide-11 is a short chain of amino acids produced in a specially cultivated potato plant that has been given the genetic instructions to make this specific peptide. Because the potato serves as a natural bioreactor the final material is considered plant derived even though modern biotechnology is used. After the potatoes are harvested the peptide is separated from the plant material then purified and gently dried into a powder that can be blended into creams or serums. Peptides first gained attention in skin care during the late 1990s when researchers showed that certain fragments of proteins could help support the skin’s natural barrier. Brands soon looked for cost effective and sustainable ways to produce these peptides and transgenic plants like potato became an attractive option. Today Potato Sh-Polypeptide-11 appears in moisturizers, anti aging serums, sheet masks, eye creams and after sun soothing lotions where it is prized for its protective qualities.

Potato Sh-Polypeptide-11’s Cosmetic Benefits/Uses

In formulas this ingredient serves one main purpose that delivers several practical advantages for the skin.

Skin protecting: The peptide sits on the surface of the skin and binds water which helps reduce moisture loss and shields against everyday irritants such as pollution and harsh weather. By keeping the outer layer of the skin better hydrated and intact it can leave the complexion feeling softer and more resilient and can also help calm the look of temporary redness caused by dryness.

Who Can Use Potato Sh-Polypeptide-11

This gentle peptide is considered suitable for all common skin types including dry, normal, combination and oily skin because it focuses on reinforcing the surface barrier rather than changing oil production or exfoliating. Sensitive skin usually tolerates it well thanks to its mild, water-binding nature, though anyone with a known potato allergy should proceed with caution since trace botanical proteins could remain in the finished extract.

Potato Sh-Polypeptide-11 is produced in a plant host and contains no animal-derived material so it aligns with vegan and vegetarian preferences.

Current safety data show no specific concerns for pregnant or breastfeeding women when the peptide is used topically in cosmetic amounts. That said this information is educational only and expectant or nursing mothers should always check with a qualified health professional before adding any new product to their routine.

The ingredient does not increase the skin’s sensitivity to sunlight so there is no added risk of photosensitivity. It also plays well with common actives such as niacinamide and hyaluronic acid making it easy to slot into most regimens.

Potential Side Effects/Adverse Reactions

Responses to any skin care ingredient can differ from person to person. The points below outline potential side effects linked to Potato Sh-Polypeptide-11 yet most users will experience none of them when the peptide is properly formulated and used as directed.

  • Mild redness or stinging in very sensitive skin
  • Allergic reaction in individuals allergic to potatoes or nightshade plants
  • Contact dermatitis triggered by other formula components such as preservatives rather than the peptide itself

If irritation or any unexpected reaction occurs stop using the product and seek guidance from a healthcare professional.

Comedogenic Rating

Rating: 0

Potato Sh-Polypeptide-11 is a small water-soluble peptide that does not contain heavy oils, waxes or fatty acids that could block pores. It sits lightly on the skin surface, binds water then rinses away easily, so it is considered non-comedogenic.

Suitable for acne-prone or breakout-prone skin.

The rating can vary if the peptide is delivered in a very rich cream, so always consider the full formula when choosing a product.

Summary

Potato Sh-Polypeptide-11 is a plant-derived peptide that acts as a skin protector by binding moisture at the surface and reinforcing the skin barrier. This helps reduce transepidermal water loss, softens texture and calms temporary redness linked to dryness.

While effective, it remains a niche ingredient found mainly in mid to high-end moisturizers, serums and after-sun products rather than mass-market lines.

Current research shows a strong safety profile with very low risk of irritation except for those with a potato allergy. As with any new skincare product, do a quick patch test first to make sure your skin agrees with the full formula.

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