Propylene Glycol Isodeceth-12: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: July 1, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Propylene Glycol Isodeceth-12?

Propylene Glycol Isodeceth-12 is a synthetic liquid derived from propylene glycol and isodecyl alcohol that has been reacted with about 12 units of ethylene oxide. This process, called ethoxylation, creates a molecule with both water loving and oil loving parts, making it useful in personal care formulas. The ingredient emerged in the late 20th century as chemists searched for milder alternatives to traditional surfactants that could clean the skin without stripping it.

Manufacturing begins with propylene glycol, a small alcohol often sourced from petroleum or plant sugars. It is combined with a branched fatty alcohol known as isodecyl alcohol, then treated with controlled amounts of ethylene oxide. The result is a clear to lightly cloudy fluid that dissolves in water and helps blend oil and water based ingredients.

You will most often spot Propylene Glycol Isodeceth-12 in facial cleansers, body washes, micellar waters, exfoliating masks, lightweight moisturizers and even some hair care products like clarifying shampoos or conditioning rinses. Its balance of cleansing power and skin friendliness makes it popular in formulas aimed at sensitive or combination skin types.

Propylene Glycol Isodeceth-12’s Cosmetic Benefits/Uses

This multitasking ingredient offers two key functions that improve how a product feels and performs on the skin.

  • Cleansing: The molecule lowers surface tension so water can mix with oil and dirt, allowing impurities to rinse away easily. This gentle action helps create a soft lather and leaves skin feeling fresh rather than tight.
  • Emulsifying: Its dual affinity for water and oil keeps creamy or lotion textures from separating. This stability means a smoother application, an even spread of active ingredients and a longer shelf life for the final product.

Who Can Use Propylene Glycol Isodeceth-12

Most skin types tolerate Propylene Glycol Isodeceth-12 well. Its mild cleansing action suits normal, oily, combination and sensitive skin since it lifts dirt without an aggressive stripping effect. People with very dry or compromised skin barriers may notice slight tightness if the ingredient is used at high levels in a formula, so richer moisturizers alongside it can help balance that out.

The ingredient is synthetically produced from petroleum or plant-derived feedstocks, with no animal by-products involved, making it appropriate for vegans and vegetarians.

Current safety assessments show no reproductive or developmental concerns at the levels used in cosmetics, so products containing Propylene Glycol Isodeceth-12 are generally considered safe for those who are pregnant or breastfeeding. This is not medical advice and anyone expecting or nursing should still check with a doctor before introducing new skincare.

Propylene Glycol Isodeceth-12 is not known to cause photosensitivity, so it will not make skin more prone to sunburn. It can be used day or night and pairs well with most other common skincare ingredients.

Potential Side Effects/Adverse Reactions

Side effects from topical Propylene Glycol Isodeceth-12 vary by individual. The points below outline potential reactions, though they are uncommon when the ingredient is formulated correctly and used as directed.

  • Transient stinging or tingling, especially on freshly shaved or broken skin
  • Mild redness or itching in those with very sensitive skin
  • Dryness if used in a high-foaming cleanser without adequate follow-up hydration
  • Rare cases of contact dermatitis or allergic sensitization
  • Eye irritation if the product accidentally gets into the eyes

If any irritation persists stop using the product and seek guidance from a healthcare professional.

Comedogenic Rating

Rating: 1/5

Propylene Glycol Isodeceth-12 is a lightweight surfactant that is water soluble and rinses off easily, so it does not linger on the skin to block pores. It lacks the heavy oils or waxes typically linked with breakouts which is why formulators consider it practically non-comedogenic.

Suitable for acne-prone or breakout-prone skin, especially in rinse-off products like cleansers and shampoos.

Because its presence in leave-on formulas is usually low and paired with other non-occlusive ingredients, the risk of pore clogging remains minimal.

Summary

Propylene Glycol Isodeceth-12 serves mainly as a gentle cleanser and an emulsifier. Its dual water-loving and oil-loving structure lets it lift away dirt and oil while keeping lotions and creams from separating, resulting in stable products that feel light on the skin.

While not a household name, it is steadily found in modern face washes, micellar waters and mild haircare because chemists value its balance of effectiveness and mildness.

Safety reviews show a low potential for irritation or toxicity at cosmetic levels, making it a dependable choice for most users. As with any new ingredient it is wise to perform a quick patch test when trying a fresh product to be sure your skin agrees with it.

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