Quaternium-79 Hydrolyzed Collagen: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Quaternium-79 Hydrolyzed Collagen?

Quaternium-79 Hydrolyzed Collagen is a specialized form of collagen that has been broken down into smaller peptides, then chemically modified with quaternary ammonium groups. These groups carry a positive charge, allowing the ingredient to cling to negatively charged surfaces like hair and skin. The collagen itself is typically sourced from animal by-products such as fish or bovine hides that have been cleaned and enzymatically hydrolyzed to create water-soluble fragments. During the next step, the fragments are reacted with compounds like 2-hydroxy-3-(dimethylammonio)propyl chloride and long-chain fatty amines, producing a blend of derivatives that combine the moisturizing qualities of collagen with the conditioning action of a quaternary salt.

The idea of blending collagen with quaternary chemistry emerged in the late 1970s when formulators were looking for ways to make protein ingredients stay on hair after rinsing. Over time Quaternium-79 Hydrolyzed Collagen found its way into salon shampoos, color-protecting conditioners and skin-softening lotions. Its manufacturing process is well established: hydrolyzed collagen is mixed in a reactor, the quaternization reagents are added under controlled pH and temperature, excess salts are washed out, and the finished liquid or powder is standardized for cosmetic use.

Today you will most often spot this ingredient in rinse-off and leave-on hair conditioners, anti-frizz serums, daily moisturizers, sheet masks and anti-aging creams where a lightweight conditioning film is desired.

Quaternium-79 Hydrolyzed Collagen’s Cosmetic Benefits/Uses

In beauty formulas Quaternium-79 Hydrolyzed Collagen offers several helpful roles that boost both product performance and the feel of skin and hair.

  • Antistatic – The positive charge neutralizes static electricity on hair, helping strands lie flat so they look smoother and are easier to style
  • Hair Conditioning – Forms a thin breathable film that improves slip, reduces tangles and adds a soft touch without weighing hair down
  • Skin Conditioning – Binds water to the skin’s surface and leaves behind a silky finish, which can make creams feel richer and masks more comforting

Who Can Use Quaternium-79 Hydrolyzed Collagen

This ingredient is generally well tolerated by dry, normal and combination skin because the positively charged collagen fragments add light moisture without leaving a greasy residue. Sensitive skin can often use it too since the molecule sits on the surface rather than penetrating deeply, though those prone to frequent sensitization should check the full formula for other triggers. Extremely oily or blemish prone skin may find rich conditioners that include Quaternium-79 Hydrolyzed Collagen feel heavy, but the ingredient itself has a low tendency to clog pores when used at standard levels.

Because the collagen is sourced from animal by products such as fish scales or bovine hide, Quaternium-79 Hydrolyzed Collagen is not suitable for vegans or strict vegetarians. Anyone trying to avoid animal derived ingredients should look for plant based alternatives labeled hydrolyzed soy protein or pea peptide.

Current data shows no specific risks for women who are pregnant or breastfeeding when the ingredient is applied topically at the small concentrations found in cosmetics. That said this is not medical advice and anyone who is pregnant or nursing should run any skincare or haircare product past a qualified doctor just to be safe.

The molecule does not make skin more sensitive to sunlight and there is no evidence that it interferes with sunscreen filters. It can be used morning or night without extra sun precautions beyond a normal broad spectrum SPF.

Potential Side Effects/Adverse Reactions

Side effects from topical Quaternium-79 Hydrolyzed Collagen can vary from one person to another. The points below outline potential reactions, but most people will not experience them when the ingredient is used at cosmetic levels in a well formulated product.

  • Mild skin irritation such as temporary redness or itching in those with very reactive skin
  • Contact allergy leading to a rash or hives in individuals sensitive to quaternary ammonium compounds
  • Eye stinging if a product rinses or drips into the eyes during use
  • Product buildup on hair causing strands to feel limp or coated when the conditioner is not cleansed out periodically
  • Follicular congestion in acne prone areas if the surrounding formula is rich in heavy oils or waxes

If any of these reactions occur stop using the product and consult a healthcare professional for further guidance.

Comedogenic Rating

Rating: 1/5 – Quaternium-79 Hydrolyzed Collagen is water soluble and designed to sit lightly on the surface without blocking pores, so its tendency to cause breakouts is very low. It can, however, contribute to a coated feel if paired with heavy oils or used in very rich leave-on formulas, which is why it is not rated a perfect zero.

Most people prone to acne should find this ingredient compatible with their routines, especially when it appears in lightweight products such as rinse-off conditioners or gel moisturizers.

Because the molecule relies on a positive charge rather than an oily backbone to condition, it does not behave like the fatty acids and waxes that usually trigger congestion. Regular cleansing will minimize the small risk of buildup that might arise with frequent use.

Summary

Quaternium-79 Hydrolyzed Collagen serves mainly as an antistatic, hair conditioning and skin conditioning agent. Its quaternary ammonium groups carry a positive charge that helps it bind to negatively charged hair and skin, forming a thin film that smooths cuticles, tames static and locks in surface moisture without a greasy afterfeel.

The ingredient enjoys steady but niche popularity, showing up more often in salon hair care and mid-range moisturizers than in mass market formulas. Brands that focus on lightweight conditioning or color protection appreciate its ability to stay put after rinsing.

Safety data and long years of cosmetic use indicate a low risk profile, with only occasional irritation or allergy in sensitive individuals. As with any new cosmetic ingredient it is wise to patch test a product containing Quaternium-79 Hydrolyzed Collagen to make sure your skin or scalp stays happy.

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