What Is R-Clostridium Histolyticum Collagenase H Hexapeptide-40?
R-Clostridium Histolyticum Collagenase H Hexapeptide-40 is a lab designed peptide blend created through modern biotechnology. Scientists stitched together the genetic blueprint for collagenase H, an enzyme originally found in the bacterium Clostridium histolyticum, with that of a performance boosting six–amino-acid fragment known as Hexapeptide-40. The combined gene is inserted into E. coli, which is then grown in stainless steel fermenters. As the bacteria multiply they produce a single chain peptide made up of 1027 amino acids. After fermentation the peptide is isolated, purified and carefully filtered to remove any bacterial leftovers, yielding a highly refined cosmetic ingredient.
The journey to skincare shelves began when peptide research revealed that certain collagen-related enzymes could help condition skin without the downsides of whole enzymes. By trimming and fusing sequences, researchers crafted a large yet stable peptide that offers the conditioning traits people want, minus significant irritation risk. Today formulators blend this ingredient into anti aging serums, rich moisturizers, overnight masks, eye creams and targeted treatment ampoules where a smoother look and feel are the goals.
R-Clostridium Histolyticum Collagenase H Hexapeptide-40’s Cosmetic Benefits/Uses
This peptide’s primary role in skincare is skin conditioning. By interacting gently with the outermost proteins of the skin it helps refine surface texture, supports a softer touch and can enhance moisture retention. Formulators add it to give products a boost in silky afterfeel and to promote a fresher, more supple appearance over time.
Who Can Use R-Clostridium Histolyticum Collagenase H Hexapeptide-40
This peptide is mild enough for most skin types including normal, dry, combination and oily skin. Those with sensitive or reactive complexions usually tolerate it well because it is non-acidic and has a neutral pH. If you have a history of bacterial or enzyme sensitivities you may want to be cautious as the peptide is derived from a collagenase sequence, yet the purification steps greatly reduce that risk.
The ingredient is produced through fermentation in E. coli and contains no animal-derived material so it is considered suitable for vegans and vegetarians.
Current data does not flag any specific issues for pregnant or breastfeeding women, but research on newer biotech peptides is still limited. This information is not medical advice and expecting or nursing mothers should ask their healthcare provider before adding any new skincare product.
R-Clostridium Histolyticum Collagenase H Hexapeptide-40 does not make skin more sensitive to sunlight so it is safe for daytime use without extra sun precautions beyond a good sunscreen habit.
Potential Side Effects/Adverse Reactions
Side effects from topical use of R-Clostridium Histolyticum Collagenase H Hexapeptide-40 vary from person to person. The points below list potential reactions but most users will not encounter them when the ingredient is formulated and used correctly.
- Mild redness or warmth shortly after application
- Temporary tingling or tightness
- Itchiness in very sensitive skin
- Rare localized swelling if combined with other strong actives
- Allergic contact dermatitis in individuals allergic to peptide sequences
If you experience any persistent discomfort, discontinue use and consult a healthcare professional.
Comedogenic Rating
Rating: 0 / 5. R-Clostridium Histolyticum Collagenase H Hexapeptide-40 is a very large water-soluble peptide that sits on the skin surface rather than sinking into pores or mixing with sebum. It contains no oily carriers or waxy residues that could trap dead cells so it has virtually no clogging potential. This makes it suitable for people prone to acne or breakouts.
The only caveat is the overall formula: if the product pairs this peptide with heavy butters or occlusive silicones the finished product’s comedogenicity may rise, but the peptide itself remains non-comedogenic.
Summary
R-Clostridium Histolyticum Collagenase H Hexapeptide-40 is used mainly for skin conditioning. By loosely interacting with surface proteins it encourages a smoother texture, better moisture retention and a softer feel without harsh exfoliation or irritation. Its biotech origin allows consistent purity so formulators can rely on predictable performance.
The ingredient is still a niche player compared with headline actives like retinol or vitamin C but it is quietly gaining traction in high-end serums and specialty moisturizers aimed at delivering a luxurious silky finish.
Overall safety data looks favorable with low irritation risk, no photosensitivity and a non-comedogenic profile. As with any new skincare addition it is smart to carry out a small patch test before full use to make sure your skin agrees with it.