Review: I Used Goldfaden MD’s “Plant Profusion Night Cream” For 2 Weeks, Here’s What Happened…

Could Goldfadden MD's new overnight treatment become my secret glow weapon?
Updated on: June 18, 2025

Image courtesy of Goldfaden MD

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Goldfadden MD may not yet be a household name on every vanity, but among dermatology insiders the Miami-born line enjoys a reputation for blending clinical know-how with green-leaning formulas. I have long admired the brand’s talent for marrying science with sensorial appeal, so when its latest creation arrived on my desk I was keen to see if it could live up to the pedigree.

The mouthful that is Plant Profusion Night Cream certainly sounds like it belongs in a botanical garden. According to Goldfadden MD, this overnight treatment taps plant stem cells, antioxidants and nourishing extracts to leave skin smoother, plumper and visibly stronger. In other words, it promises the kind of morning-after glow we all covet without a twelve-step routine.

I committed to a full two-week test drive, applying it nightly over my usual serum to gauge firmness, hydration and any changes in fine lines. The goal was simple: find out whether this jar deserves a permanent spot on your nightstand or should remain a flirtation.

Disclaimer: This is not a paid or sponsored review. All thoughts are my own, based on personal experience. As always, skincare results can vary depending on individual skin type, concerns and routine.

What Is Plant Profusion Night Cream?

Plant Profusion Night Cream sits in the overnight treatment category, meaning it is designed to be the last step before bed and stay on while skin goes through its nightly repair cycle. These leave-on formulas are typically richer than day creams so they can shore up the moisture barrier, deliver actives over several hours and help you wake to skin that feels replenished.

This particular cream from Goldfadden MD combines plant stem cells, antioxidants and a roster of botanical extracts aimed at smoothing texture, lending a plumper appearance and supporting firmness. The ingredient mix is intended to reinforce the skin’s surface and fight the look of fine lines that tend to be more pronounced in the morning.

Usage is straightforward: cleanse, apply your serum of choice, then massage a thin layer of the cream over the face using upward circular motions. Consistent nightly use is recommended for anyone interested in assessing its full effect on hydration and resilience.

Did It Work?

In the spirit of rigorous beauty journalism I benched my usual overnight cream for the first three nights – very scientific, I know – then relied solely on Plant Profusion for the full 14-day stretch. I applied it each evening after a hydrating serum, sticking to the recommended pea-size amount and working it in with upward circles as directed.

Night one delivered what I call the “fresh paint” effect: skin felt cushioned and looked slightly dewy but nothing more. By the fourth night I noticed a modest uptick in morning smoothness, especially across my cheeks where dehydration lines like to camp out. The formula has a comforting balm-cream texture that sealed in moisture without feeling greasy, although on two occasions it did sit on top of my skin and leave a faint film by morning, possibly because I layered it over a richer serum.

Week two is when any firmness claims usually reveal themselves. My jawline did feel a touch bouncier and the fine parentheses around my mouth seemed softer under bathroom lighting, yet the change was subtle enough that I had to squint to be sure. Hydration remained consistent and I experienced zero irritation, which is worth noting given the cocktail of botanicals inside. However, I cannot say my complexion looked dramatically stronger or that lines truly retreated.

All in, Plant Profusion delivered reliable overnight moisture and a mild smoothing benefit but fell short of the transformative results its ingredient list implies. I enjoyed using it and would happily finish the jar yet I am not rushing to retire my usual night cream. In other words it works, just not quite hard enough to earn a permanent slot on my shelf.

Main Ingredients Explained

The star of the show is a blend of plant stem cell extracts headed by Strelitzia Reginae, sometimes called Bird of Paradise. Lab studies suggest these cells can nudge skin into producing new collagen and elastin, which in theory translates to a firmer feel over time. Supporting players like Fucus Serratus and Ascophyllum Nodosum, two mineral-rich seaweeds, bring a rush of polysaccharides that bind water in the upper layers so skin wakes up looking comfortably hydrated rather than parched.

Hyaluronic acid is the moisture magnet everyone wants in a night cream. The molecule can hold up to 1,000 times its weight in water and here it helps plump fine lines temporarily so they are less noticeable at sunrise. Squalane, sourced from plants not sharks, mimics the natural lipids found in our sebum which is why it feels lightweight yet seals in moisture effectively. Red tea, white tea and grape juice extracts supply antioxidants that mop up the free radicals our skin collects during the day. Pomegranate seed extract adds another antioxidant layer and has been linked to mild collagen-boosting activity in vitro.

On the texture front, coco-caprylate and cetearyl alcohol lend the cream its silky glide. While cetearyl alcohol is generally considered safe, it sits around a 2 to 3 on the comedogenic scale which means it can clog pores for those who are extremely acne-prone. A quick refresher: comedogenicity refers to an ingredient’s tendency to block pores and create bumps known as comedones.

Good news for anyone avoiding animal derivatives: the ingredient list is entirely plant-based so the formula looks suitable for vegans and vegetarians. Phenoxyethanol and ethylhexylglycerin serve as preservatives at concentrations well within accepted safety limits but as always patch testing is prudent.

Pregnancy safety is a nuanced subject. None of the listed ingredients are flagged as high-risk however hormonal shifts can make skin unpredictable. Expecting or nursing individuals should run any new topical past their healthcare provider before diving in.

One final note: the cream is free of added fragrance so the faint herbal scent you pick up comes solely from the raw botanicals. That makes it a considerate option for noses and skin types that bristle at perfume in skincare.

What I Liked/Didn’t Like

Below is a straightforward rundown of the highs and lows from my two-week trial.

What Works Well:

  • Comforting balm-cream texture seals in hydration without a greasy after-feel
  • Smooths dehydration lines by morning and keeps skin consistently cushioned
  • Vegan formula rich in antioxidants and plant stem cells appeals to ingredient-savvy users

What to Consider:

  • Firming and wrinkle softening are subtle so results may not satisfy seekers of dramatic change
  • Can leave a light film if paired with a heavy serum which might not suit oilier complexions
  • Positioned at the pricier end of the night cream spectrum

My Final Thoughts

Plant Profusion and I spent a solid fortnight together and we got along pretty well, if not passionately. It is the sort of overnight treatment I would hand to a friend who values gentle hydration and a soft morning canvas yet is willing to temper expectations about any major lift in firmness. Seasoned skincare explorers chasing fast, visible wrinkle reversal might crave a formula with more aggressive actives, while oilier skins could find the occasional surface film a nuisance. On my combination complexion it behaved nicely, left no irritation and earned a respectable 7/10 on my personal scorecard. Would I recommend it? Yes, with the caveat that you view it as a dependable night-time moisturiser rather than an age-rewind potion.

If you love the idea of a multitasking night cream but want to weigh your options, a few tried-and-tested alternatives spring to mind. Nocturnal Revive Cream by Deascal is my reigning allrounder, a covers-all-bases formula that suits virtually every skin type and costs less per ounce than a fancy latte habit. Advanced Night Restore by Medik8 packs ceramides and peptides into a surprisingly breathable cream that has rescued my skin after long-haul flights. Those craving a pillow-soft bounce will appreciate the marshmallow texture of Pro-Collagen Overnight Matrix from ELEMIS, which leaves cheeks feeling delightfully springy. For barrier support on stressed days Squalane + Ectoin Overnight Rescue by Biossance remains a quiet hero, cocooning skin without suffocating it. I have rotated through each of these jars and can vouch for their merit depending on your moisture, firmness and price priorities.

Before you slather anything new across your face remember a few basics. Patch test on a discreet area first even if you feel impatient, sustained use is key because results fade the moment you ghost your routine and please forgive me for sounding like an over-protective parent.

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