What Is Rh-Polypeptide-11 Dipeptide-19 Oligopeptide-91 Hexapeptide-40?
Rh-Polypeptide-11 Dipeptide-19 Oligopeptide-91 Hexapeptide-40 is a lab designed fusion peptide made up of 184 amino acids. Scientists build its gene by linking together genetic sequences that code for four smaller peptides, then insert that gene into a harmless strain of E. coli. During fermentation the bacteria act like miniature factories, producing large amounts of the peptide. After the cells are harvested the peptide is purified and blended into a stable cosmetic grade ingredient.
Peptide technology began gaining attention in the skin care world during the early 2000s when researchers discovered that these short chains of amino acids could send signals to skin cells. As demand grew for more targeted results, brands started to combine different peptide sequences into one molecule, which led to complex hybrids like Rh-Polypeptide-11 Dipeptide-19 Oligopeptide-91 Hexapeptide-40. Today you will most often see it in lightweight anti aging serums, firming creams, leave-on hair masks, scalp treatments and soothing moisturizers aimed at strengthening the skin barrier.
Rh-Polypeptide-11 Dipeptide-19 Oligopeptide-91 Hexapeptide-40’s Cosmetic Benefits/Uses
This multi-tasking peptide brings several helpful functions to modern beauty formulas
- Hair conditioning: Forms a weightless film along the hair shaft that smooths cuticles, boosts softness and helps reduce breakage when brushing or styling
- Skin conditioning: Supports the skin’s natural proteins, improving suppleness and a plump look while leaving a silky finish
- Skin protecting: Reinforces the outer barrier so skin can better retain moisture and stay resilient against daily stressors like pollution or temperature changes
Who Can Use Rh-Polypeptide-11 Dipeptide-19 Oligopeptide-91 Hexapeptide-40
This gentle peptide suits most skin types, including dry, oily, combination and sensitive skin, because it is lightweight and free of common irritants like fragrance or alcohol. People with very reactive or allergy-prone skin can usually tolerate it, though they should still pay attention to the full ingredient list of any product since other components may trigger issues.
The molecule is produced through bacterial fermentation with no animal-derived materials, making it appropriate for vegans and vegetarians.
Current safety data shows no specific risks for pregnant or breastfeeding women when the peptide is applied topically. That said this is not medical advice and anyone who is expecting or nursing should review new skincare products with a qualified healthcare provider to be extra safe.
The ingredient does not absorb UV light or interfere with melanin production, so it does not cause photosensitivity. It can be used morning or night alongside regular sunscreen during the day.
Potential Side Effects/Adverse Reactions
Reactions to topical Rh-Polypeptide-11 Dipeptide-19 Oligopeptide-91 Hexapeptide-40 vary from person to person. The points below outline potential side effects, but most users experience none when the ingredient is correctly formulated and used as directed.
- Mild redness or warmth in very sensitive skin, usually short lived
- Itching or tingling if applied to broken or compromised skin
- Contact dermatitis in the rare case of an individual peptide allergy
- Eye irritation if the product accidentally gets into the eyes
If any of these effects occur discontinue use and seek advice from a dermatologist or healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Rh-Polypeptide-11 Dipeptide-19 Oligopeptide-91 Hexapeptide-40 is a large, water-soluble peptide that sits on the surface of skin rather than settling into pores. It has no oily or waxy components, so it does not create the kind of buildup that can trap sebum or bacteria. Because of this, it earns the lowest possible comedogenic score.
People who struggle with acne or frequent breakouts can generally use this ingredient without worrying about clogged pores.
The only caveat is the full product formula. If the peptide is blended into a cream rich in heavier oils or butters, those other ingredients could still trigger congestion even though the peptide itself will not.
Summary
Rh-Polypeptide-11 Dipeptide-19 Oligopeptide-91 Hexapeptide-40 conditions hair, conditions skin and protects the skin barrier. It does this by forming a light film that smooths hair cuticles, sending supportive signals to skin cells so they hold on to moisture and reinforcing the outer layer that keeps irritants out.
The peptide is a newer, niche addition to cosmetic formulas but its multitasking nature is making it more popular in targeted serums, leave-on conditioners and barrier creams.
Current research and real-world use show it is well tolerated for most people with no major safety red flags. As with any new skincare ingredient it is smart to patch test a small area first to confirm personal compatibility.