What Is Rh-Polypeptide-22?
Rh-Polypeptide-22 is a lab created version of a human protein related to transforming growth factor beta 1. Scientists start with the exact human gene that holds the instructions for this protein then insert it into a harmless strain of E. coli. As the bacteria ferment, they act like tiny factories, churning out the peptide in large amounts. After fermentation, the protein is carefully purified and checked so it matches the sequence of the 20 standard amino acids and may contain natural add-ons like disulfide bonds or small sugar groups.
The idea of using growth factor inspired peptides in cosmetics took off in the early 2000s when researchers realized these molecules could signal skin to look and act younger. Rh-Polypeptide-22 found its way into skincare labs soon after thanks to advances in recombinant technology that made production reliable, vegan friendly and free of human or animal tissue.
Today you will most often spot this ingredient in premium serums, anti-aging moisturizers, sheet masks, eye creams and leave-on treatments aimed at firmness or overall skin vitality.
Rh-Polypeptide-22’s Cosmetic Benefits/Uses
In formulas Rh-Polypeptide-22 performs a single but valuable role.
As a skin-conditioning agent it helps support the skin’s own repair signals, encouraging a smoother surface, better hydration retention and a more resilient feel. Regular use can translate to softer texture, improved suppleness and a visibly refreshed complexion.
Who Can Use Rh-Polypeptide-22
Most skin types tolerate Rh-Polypeptide-22 well including dry, oily, combination and sensitive skin since the peptide itself is lightweight and non-comedogenic. Exceptionally reactive skin or individuals with known sensitivities to ferment derived proteins should proceed cautiously because any peptide can, in rare cases, trigger irritation.
The ingredient is produced in E. coli through fermentation without animal tissues so it is suitable for vegans and vegetarians.
No specific warnings exist for pregnant or breastfeeding women however research on topical use during pregnancy is limited. This information is not medical advice and anyone expecting or nursing should show the full product ingredient list to a health professional before adding it to a routine.
Rh-Polypeptide-22 does not make skin more prone to sunburn and can be used morning or night without extra risk of photosensitivity. It also pairs well with common actives like niacinamide or hyaluronic acid so there are few compatibility concerns.
Potential Side Effects/Adverse Reactions
Side effects from topical Rh-Polypeptide-22 differ from person to person. The points below list potential reactions yet most users will not experience them when the ingredient is formulated and used correctly.
- Mild redness or temporary irritation in very sensitive skin
- Allergic contact dermatitis for those with a specific protein allergy
- Stinging if applied over broken or freshly exfoliated skin
- Occasional breakouts in acne prone skin when used in a heavy cream base
If any unwanted reaction occurs discontinue use and consult a qualified healthcare professional.
Comedogenic Rating
Rh-Polypeptide-22 scores a 0 out of 5 on the comedogenic scale. It is a large, water-soluble peptide with no oily or waxy residues so it does not clog pores on its own. Formulas that feature it are usually lightweight serums or gels that rinse clean and leave no occlusive film.
Because of this low rating, the ingredient is generally considered suitable for people prone to acne or breakouts. Any risk comes more from the overall product base rather than the peptide itself.
As with any water-based active, the purity of the raw material and the presence of other comedogenic emollients in the finished product can influence how skin responds, but Rh-Polypeptide-22 alone poses virtually no pore-blocking threat.
Summary
Rh-Polypeptide-22 is a lab engineered growth-factor-inspired peptide used chiefly for skin conditioning. By mimicking signals linked to transforming growth factor beta 1 it encourages smoother texture, better moisture retention and a more resilient feel.
Although not as mainstream as hyaluronic acid or niacinamide, this peptide is gaining traction in high-end serums and targeted anti-aging treatments thanks to advances in recombinant technology that make it vegan friendly and reliably pure.
Overall safety is high with very few reports of irritation or pore blockage. Still, skin can be unpredictable so it is wise to patch test any new product containing Rh-Polypeptide-22 before adding it fully into your routine.