What Is Rh-Polypeptide-60?
Rh-Polypeptide-60 is a lab made chain of amino acids modeled after the natural protein superoxide dismutase, also known as SOD 1. Scientists recreate the sequence through biotechnology, starting with harmless bacteria or yeast that are given the genetic blueprint to build the peptide. After fermentation the peptide is purified, filtered and blended into a stable cosmetic grade powder or solution.
The idea of putting SOD inspired peptides on skin took off in the early 2000s when researchers found they could copy the antioxidant power of the original enzyme without needing to extract it from animal tissue. Thanks to that breakthrough Rh-Polypeptide-60 began appearing in premium skin care as a modern alternative to plant antioxidants.
You will usually spot this ingredient in serums, anti aging creams, sheet masks, eye treatments and post procedure soothing gels. Formulators like it because it works in both water based and lightweight emulsion products, making it easy to add to daytime and night time routines.
Rh-Polypeptide-60’s Cosmetic Benefits/Uses
In topical products Rh-Polypeptide-60 plays two key roles that support healthier looking skin.
- Reducing agent: It helps neutralize surface free radicals created by UV rays and pollution, which can lessen the look of dullness and delay visible signs of aging
- Skin conditioning: The peptide supports the skin barrier, helping it hold moisture so skin feels softer, smoother and more comfortable throughout the day
Who Can Use Rh-Polypeptide-60
Rh-Polypeptide-60 is gentle enough for most skin types, including dry, normal, combination and oily skin. Those with sensitive skin usually tolerate it well because it is free of fragrances and harsh solvents. If your skin is very reactive or you have a known allergy to peptides you might want to be more cautious, but for most people it is considered non irritating.
The peptide is made through biotechnology in a controlled lab setting using microorganisms, not animals, so products that use a cruelty free supplier are generally suitable for vegans and vegetarians. Always check the full ingredient list and brand ethics if this point is important to you.
There is no published evidence that Rh-Polypeptide-60 poses a risk to pregnant or breastfeeding women when used on the skin. Still this is not medical advice. If you are expecting or nursing speak with your healthcare provider before starting any new skincare product just to be safe.
Unlike alpha hydroxy acids or retinoids this peptide does not make skin more sensitive to the sun, so it is safe for day and night routines. Of course using a broad spectrum sunscreen in the morning is still a smart move for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to any cosmetic ingredient can differ from one person to another. The points below cover potential issues you could encounter with topical Rh-Polypeptide-60 but they are uncommon when the formula is well made and used as directed.
- Mild redness or warmth
- Temporary stinging on very compromised or freshly exfoliated skin
- Itching or small bumps in individuals with a peptide sensitivity
- Contact dermatitis triggered by other ingredients in the formula rather than the peptide itself
If you notice any discomfort that persists or worsens stop using the product and consult a healthcare professional.
Comedogenic Rating
Rating: 0/5
Rh-Polypeptide-60 is a small, water-soluble peptide with no oily or waxy components so it does not obstruct pores. It sits on the skin surface, does its antioxidant work then rinses or wears away without leaving residue that could trap sebum or dead cells. That is why formulators consider it non-comedogenic.
This makes the ingredient a good choice for people who are prone to acne or breakouts, provided the rest of the formula is also lightweight and non-clogging.
As always the total product matters: rich creams, heavy butters or comedogenic sunscreens can still cause congestion even if the peptide itself is pore friendly.
Summary
Rh-Polypeptide-60 is a lab designed replica of superoxide dismutase that acts as a surface antioxidant and skin conditioner. By scavenging free radicals it helps reduce dullness and early signs of aging while supporting the moisture barrier so skin feels smoother and more comfortable.
The peptide is still a niche ingredient, usually found in mid to high-end serums and post-procedure gels rather than in everyday drugstore ranges, but its profile is growing as brands look for biotech alternatives to plant antioxidants.
Overall safety data are reassuring. It is non-comedogenic, generally non-irritating and produced without animal sources. Even so each person’s skin is unique so it is wise to patch test any new product that contains Rh-Polypeptide-60 before applying it to the entire face.