What Is Rh-Polypeptide-79?
Rh-Polypeptide-79 is the cosmetic name for peroxiredoxin-1, a small protein that naturally occurs in the body where it helps neutralize harmful oxygen molecules. In skin care labs scientists isolate the gene that codes for this protein then use safe, bioengineered yeast or bacteria to produce large quantities through a fermentation process. After purification the polypeptide is blended into water-based solutions that can be easily added to finished formulas.
The ingredient first attracted attention in the early 2000s when researchers studying cellular aging noticed that peroxiredoxin-1 levels dropped in older skin. Formulators soon explored its topical use to reinforce the skin’s own defense system. Today you will most often find Rh-Polypeptide-79 in anti-aging serums, daily moisturizers, revitalizing masks and products aimed at protecting skin from urban stressors such as pollution and blue light.
Rh-Polypeptide-79’s Cosmetic Benefits/Uses
In formulas Rh-Polypeptide-79 works in two key ways
- Antioxidant: Helps mop up free radicals created by UV rays and pollution which can otherwise trigger dullness, fine lines and uneven tone. By reducing this oxidative stress the ingredient supports a fresher, more resilient complexion.
- Skin Protecting: Forms a light molecular shield that reinforces the skin barrier, helping it stay hydrated and less reactive to everyday environmental aggressors. This makes the overall formula gentler on sensitive or stressed skin.
Who Can Use Rh-Polypeptide-79
This peptide is generally suitable for all skin types including oily, dry, combination and sensitive skin because it is lightweight water soluble and non occlusive. Those with easily irritated or reactive skin may even find it calming thanks to its barrier supporting action. There are no known concerns for acne-prone skin although people experiencing active breakouts may prefer a multi-ingredient routine that also targets excess oil and bacteria.
Rh-Polypeptide-79 is produced through fermentation in yeast or bacteria rather than extracted from animals so products featuring it are typically vegan and vegetarian friendly. Always check the full ingredient list for accompanying animal derived additives such as beeswax or lanolin if that is important to you.
No evidence suggests that topical use is harmful during pregnancy or while breastfeeding. Because individual circumstances differ and research on many cosmetic actives is limited this information is not medical advice; expectant or nursing mothers should ask their healthcare provider before adding any new product.
The ingredient does not increase photosensitivity so it can be used morning or night. Daily sunscreen is still recommended since ultraviolet exposure remains the main driver of skin aging.
Potential Side Effects/Adverse Reactions
Responses to topical Rh-Polypeptide-79 vary by individual. The points below represent potential side effects that could occur even though most people experience none when the ingredient is used at typical cosmetic levels.
- Mild redness or warming sensation
- Temporary itching in very sensitive skin
- Allergic contact dermatitis if you have a specific protein allergy
- Interaction with highly acidic exfoliants that may destabilize the peptide and reduce effectiveness
If any irritation or unexpected reaction develops discontinue use and consult a healthcare professional or dermatologist.
Comedogenic Rating
Rh-Polypeptide-79 has a comedogenic rating of 0. It is a lightweight water-soluble protein that does not leave an oily film or block pores, so it is considered non-comedogenic. This makes it suitable for people who are prone to acne or frequent breakouts. If the peptide appears in a formula rich in heavy oils or waxes those other ingredients, not the peptide itself, would be the more likely culprits behind clogged pores.
Summary
Rh-Polypeptide-79 acts mainly as an antioxidant and skin protectant. By neutralizing free radicals it helps keep skin looking brighter and smoother, while its ability to shore up the barrier reduces moisture loss and sensitivity. Although it is not yet a household name, interest in lab-made peptides is growing so you will probably see it featured in a wider range of serums and moisturizers over the next few years. Overall the ingredient is well tolerated across skin types with a very low risk of irritation. As with any new skin care product it is smart to patch test first to be sure your skin agrees with the full formula.