What Is Rh-Polypeptide-96?
Rh-Polypeptide-96 is the cosmetic name for recombinant human serum albumin, a large water-binding protein that naturally occurs in blood plasma. In skin care it is made in a laboratory by inserting the human albumin gene into yeast or bacteria, which then produce the protein during fermentation. The resulting albumin is purified, dried and blended into cosmetic bases. Because it is bioidentical to the protein found in the body, it is considered highly compatible with skin.
Use of serum albumin in beauty formulas dates back several decades, when researchers noticed its ability to hold water and give a temporary tightening feel. Early versions were animal-derived, but advances in biotechnology led to cruelty-free recombinant production, paving the way for Rh-Polypeptide-96 to appear in modern products. Today you might spot it in sheet masks, anti-aging creams, lightweight moisturizers, hydrating serums, eye treatments and post-procedure calming gels.
Rh-Polypeptide-96’s Cosmetic Benefits/Uses
Rh-Polypeptide-96 brings several useful actions to a formula, helping both product performance and the feel on skin.
- Humectant: Attracts and binds water, boosting skin hydration and giving a plumper look
- Skin Conditioning: Forms a soft, flexible film that smooths the surface and can create a subtle lifting sensation
- Solvent: Helps dissolve certain active ingredients so they spread evenly and remain stable in the formula
- Cleansing: Assists in lifting dirt and oil when used in rinse-off products, supporting a gentle yet effective cleanse
Who Can Use Rh-Polypeptide-96
Rh-Polypeptide-96 is generally suitable for all skin types, including dry, normal, combination and oily. Its water-binding ability supports hydration without adding heavy oils, which makes it a comfortable option even for acne-prone or easily congested skin. Sensitive skin users typically tolerate it well because the molecule is bioidentical to a naturally occurring protein, though anyone with a history of albumin allergy should proceed cautiously.
The ingredient is produced through recombinant fermentation, so no animal tissue is involved. This cruelty-free process makes Rh-Polypeptide-96 appropriate for vegans and vegetarians.
Current data does not show any specific risks related to pregnancy or breastfeeding when the protein is applied topically, but this is not medical advice. Pregnant or nursing individuals should always discuss new skincare products with their doctor to stay on the safe side.
Rh-Polypeptide-96 is not known to increase photosensitivity, so it does not make skin more prone to sunburn. Standard daytime sun protection is still recommended as part of a well-rounded routine.
Potential Side Effects/Adverse Reactions
Responses to topical Rh-Polypeptide-96 can vary from person to person. The following points outline potential but unlikely side effects when the ingredient is used at cosmetic levels in a well-formulated product.
- Localized irritation redness, stinging or warmth shortly after application
- Dry or tight feeling if the protein film forms without enough accompanying moisturizers
- Allergic contact dermatitis rare but possible in individuals sensitized to albumin
- Breakouts in very acne-prone skin if the overall formula is occlusive or if the film traps sebum
If you develop any persistent discomfort or visible reaction stop using the product and seek guidance from a dermatologist or other qualified healthcare provider.
Comedogenic Rating
Rating: 0/5 Rh-Polypeptide-96 is a water-soluble protein that does not contain oils or waxes known to block pores. Its large molecular size tends to sit on the skin surface rather than seeping into follicles, so it is unlikely to trap sebum or dead cells. This makes it a low-risk choice for people prone to acne or breakouts. Keep in mind that the overall formula still counts; if the product also includes rich butters or heavy silicones, pore congestion can come from those ingredients instead of the albumin.
Summary
Rh-Polypeptide-96 is a lab-made version of human serum albumin that works as a humectant, skin-conditioning film former, mild solvent and gentle cleansing aid. It binds water to boost hydration, smooths and lightly tightens the surface for a quick refreshed look, helps dissolve certain actives so they stay even in the mix and assists in lifting debris in wash-off products.
The ingredient is gaining moderate popularity thanks to advances in biotech manufacturing and the current interest in vegan alternatives to animal proteins. You will mainly see it in sheet masks, lightweight serums and post-procedure gels rather than in every moisturizer on the shelf.
Topical use is considered very safe for most people, with irritation or allergy reported only rarely. As with any new skin care item it is wise to do a quick patch test before full use, just to be sure your skin agrees with the formula.