Rice Decapeptide-1 Dipeptide-56 Amide Sp: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Rice Decapeptide-1 Dipeptide-56 Amide Sp?

Rice Decapeptide-1 Dipeptide-56 Amide Sp is a blend of two short chains of amino acids sourced from rice protein. Scientists separate these peptides from whole rice grains through enzymatic hydrolysis, then refine and stabilize them by turning one end of the molecule into an amide so the peptides stay active longer on skin. Interest in rice-derived skincare dates back centuries to Asian beauty rituals that used rice water for its softening effect. Modern labs isolated the specific decapeptide and dipeptide only in the past decade, giving formulators a concentrated version of rice’s skin-friendly elements. Today you will spot this ingredient in lightweight serums, hydrating masks, daily moisturizers, anti-aging creams, eye treatments and soothing after-sun lotions where its mild nature fits sensitive skin formulas.

Rice Decapeptide-1 Dipeptide-56 Amide Sp’s Cosmetic Benefits/Uses

Its main role in formulas is as a skin conditioning agent that helps skin feel softer, smoother and more supple. By supporting the surface barrier and attracting lightweight moisture, it leaves the complexion looking fresh and well hydrated while improving the slip and spreadability of the product itself.

Who Can Use Rice Decapeptide-1 Dipeptide-56 Amide Sp

This peptide blend is generally suitable for all skin types including dry, oily, combination and sensitive skin because it is mild and non-occlusive. It is water soluble so it will not leave a heavy film that might bother acne-prone users. Since the raw material is sourced entirely from rice it meets vegan and vegetarian standards and contains no animal by-products or animal-derived processing aids.

There are no published concerns about the ingredient for women who are pregnant or breastfeeding. Its molecules do not penetrate deeply or act hormonally but this is not medical advice and anyone expecting or nursing should clear any new skincare product with a healthcare professional to be safe.

The peptide does not make skin more reactive to sunlight, so it can be applied morning or night without raising photosensitivity. It is also fragrance free and compatible with most common actives such as niacinamide or hyaluronic acid, making it easy to slot into existing routines.

Potential Side Effects/Adverse Reactions

Reactions to topical Rice Decapeptide-1 Dipeptide-56 Amide Sp vary from person to person. The points below list potential side effects, yet they are considered uncommon when the ingredient is correctly formulated and used as directed.

  • Mild redness or warmth immediately after application
  • Transient itching in very sensitive skin
  • Rare localised rash or hives in individuals allergic to rice proteins
  • Increased oiliness if the finished product contains rich emollients alongside the peptide

If any of these effects occur discontinue use and consult a healthcare professional or dermatologist for guidance.

Comedogenic Rating

Rating: 0 / 5 – Rice Decapeptide-1 Dipeptide-56 Amide Sp is fully water soluble and lacks heavy oils or waxes that can block pores. Its small peptide structure rinses away easily and does not sit inside follicles so it earns the lowest possible score. This means it is considered suitable for people who are prone to acne or frequent breakouts. Because the ingredient is usually paired with lightweight bases, there is little risk of pore congestion, though finished formulas that contain additional rich emollients could still trigger issues for some users.

Summary

Rice Decapeptide-1 Dipeptide-56 Amide Sp is a rice derived peptide blend that conditions skin by supporting the outer barrier, attracting light moisture and improving product glide. In formulas it helps the face feel softer and look more refreshed without adding weight or grease.

The ingredient sits in the “rising star” category of skincare actives. It is not as famous as hyaluronic acid or niacinamide, yet more brands are adopting it for gentle hydration and a clean label story tied to rice heritage.

Overall safety is high with a very low rate of irritation or pore clogging. As with any new cosmetic try a small patch first to make sure your individual skin agrees with it before applying more broadly.

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