Rice Oligopeptide-91 Sh-Polypeptide-9: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Rice Oligopeptide-91 Sh-Polypeptide-9?

Rice Oligopeptide-91 Sh-Polypeptide-9 is a lab crafted peptide made inside rice plants. Scientists give the plant a copy of the gene that codes for a fusion of two human-identical peptides, Oligopeptide-91 and Sh-Polypeptide-9. As the rice grows it follows that genetic recipe and builds a 186-amino-acid protein using the 20 common building blocks found in all life. The finished molecule can form helpful disulfide links and pick up natural sugar groups, which can improve its stability and ability to hold water.

After harvesting the rice grain the protein is separated, filtered and gently refined to remove plant matter. The result is a water-soluble powder or solution that slips easily into cosmetic formulas.

Because rice is a food crop with a long track record of safety the idea of growing skincare peptides in it gained traction in the early 2000s. Brands were looking for sustainable vegan alternatives to animal-derived collagen or lab fermentation. The rice method offered large yields, consistent quality and a lower carbon footprint, so formulators soon began adding the peptide to products aimed at hydration and age defense.

Today you will spot Rice Oligopeptide-91 Sh-Polypeptide-9 in light serums, sheet masks, moisturizers, eye creams, soothing after-sun gels and barrier repair treatments where it supports a plump smooth look.

Rice Oligopeptide-91 Sh-Polypeptide-9’s Cosmetic Benefits/Uses

In skin care this ingredient pulls double duty by attracting moisture and helping the skin feel soft and supple.

  • Humectant – draws water from the environment and the deeper layers of the skin to the surface which boosts hydration levels, makes the skin look dewy and can temporarily soften fine lines
  • Skin conditioning – leaves a silky film that smooths rough spots, improves the feel of a formula during application and supports a healthier skin barrier over time

Who Can Use Rice Oligopeptide-91 Sh-Polypeptide-9

This peptide suits nearly all skin types. Dry complexions appreciate its humectant pull while oily and combination skin benefit from its light water based texture that does not clog pores. Sensitive skin generally tolerates it because it is free of common irritants though anyone with a known rice protein allergy should be cautious.

The ingredient is grown in rice and refined without animal derived mediums so it meets vegan and vegetarian standards.

No studies link Rice Oligopeptide-91 Sh-Polypeptide-9 to hormonal disruption which means products containing it are not automatically off limits for pregnant or breastfeeding users. That said this is not medical advice and anyone expecting or nursing should show the full ingredient list to their healthcare provider for personalized guidance.

The molecule does not increase photosensitivity. Daily sunscreen is always smart but this peptide does not make skin more prone to sunburn.

Potential Side Effects/Adverse Reactions

Individual responses to topical Rice Oligopeptide-91 Sh-Polypeptide-9 vary. The points below describe potential side effects which are uncommon when the ingredient is properly formulated and used as directed.

  • Mild redness or stinging in very sensitive skin
  • Contact dermatitis in people allergic to rice proteins or peptides
  • Rare clogged pores if the finished product combines the peptide with heavy occlusives on oil prone skin
  • Interaction with other formula components such as preservatives leading to unexpected irritation

If you experience persistent discomfort stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 0 / 5 (non-comedogenic)

Rice Oligopeptide-91 Sh-Polypeptide-9 is a large water-soluble peptide that does not leave an oily residue or create an occlusive film, so it does not trap sebum or dead cells inside pores. It is used at low concentrations and is usually paired with lightweight delivery systems, which further lowers the risk of congestion.

This makes the ingredient suitable for skin that is prone to acne or breakouts.

As always the overall pore-clogging potential of a finished product depends on the full formula, so check the accompanying oils, waxes or silicones if you are highly blemish-prone.

Summary

Rice Oligopeptide-91 Sh-Polypeptide-9 acts as a humectant and skin conditioner. It attracts water into the outer layers then forms a thin flexible film that smooths texture and supports the barrier, helping skin look plump and feel soft.

Although not yet as common as hyaluronic acid or collagen, the peptide is gaining attention among brands that focus on biotech and vegan sourcing thanks to its sustainable rice-based production and gentle performance.

Current safety data shows a very low risk of irritation or sensitization for most users. Still, skin is individual so perform a patch test when trying any new product that contains this ingredient just to be on the safe side.

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