Rice Sh-Oligopeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Rice Sh-Oligopeptide-1?

Rice Sh-Oligopeptide-1 is a short chain of amino acids that has been produced in genetically modified rice. This small protein is similar to a natural skin signal called epidermal growth factor, which tells skin cells to renew themselves. Scientists first explored plant based versions of this factor to avoid animal sourcing and to make large scale production simpler. Using rice as a host crop turned out to be reliable, cost-effective and free from animal by-products, so the ingredient gained attention in modern skincare around the early 2000s.

The process starts with inserting the DNA code for the desired peptide into rice plants. As the rice grows it makes the peptide inside its grains. After harvest the grains are milled, the peptide is extracted with water, then it is filtered and purified until a highly concentrated, clear solution is obtained. The final material is blended into cosmetic bases at very low levels because only tiny amounts are needed for a visible effect.

You will most often spot Rice Sh-Oligopeptide-1 in anti-aging serums, sheet masks, eye creams, soothing gels and recovery treatments aimed at boosting radiance and smoothness. It can also appear in lightweight moisturizers for day or night use.

Rice Sh-Oligopeptide-1’s Cosmetic Benefits/Uses

This ingredient is prized for its skin conditioning role. By mimicking the skin’s own renewal signals it encourages fresh cell turnover, which may help soften fine lines and rough texture while supporting a plump hydrated look. It also reinforces the surface barrier so skin feels more resilient and looks healthier over time.

Who Can Use Rice Sh-Oligopeptide-1

Rice Sh-Oligopeptide-1 suits most skin types including dry, normal, combination, oily and even delicate sensitive complexions because it is lightweight and non greasy. Those with very reactive or compromised skin should still proceed cautiously if their barrier is already inflamed as any new active could feel tingly on damaged areas.

Since the peptide is produced in rice and contains no animal derived substances it meets vegan and vegetarian standards, making it a welcome option for plant-based shoppers.

There are no specific warnings against use while pregnant or breastfeeding. Nonetheless research on cosmetic peptides in these life stages is limited, so this is not medical advice and anyone expecting or nursing should show the full ingredient list of their chosen product to a qualified doctor just to be safe.

Rice Sh-Oligopeptide-1 does not make skin more sensitive to sunlight, so there is no special need for extra sun precautions beyond the daily broad-spectrum SPF that dermatologists already recommend.

The ingredient mixes well with most common skincare actives such as niacinamide, hyaluronic acid, antioxidants and mild exfoliating acids, so it can fit easily into existing routines.

Potential Side Effects/Adverse Reactions

Responses to any topical ingredient differ from person to person. The effects listed below are possible but uncommon when Rice Sh-Oligopeptide-1 is used in a properly formulated product.

  • Temporary redness or warmth after application
  • Mild itching or stinging, especially on broken skin
  • Dry patches if used alongside very strong exfoliants
  • Allergic contact dermatitis marked by persistent rash or swelling
  • Eye irritation if the product migrates into the eyes

If you experience any of these reactions stop using the product and seek advice from a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0 / 5 (non-comedogenic)

Rice Sh-Oligopeptide-1 is a small water-based peptide that contains no heavy oils, waxes or fatty acids that could clog pores. It is used at very low concentrations and absorbs quickly, leaving no residue that might trap dead skin or sebum. Because of this it poses virtually no risk of forming comedones.

Suitable for acne-prone and breakout-prone skin.

Keep in mind that overall pore clogging potential depends on the full formula, so pair this peptide with lightweight bases if congestion is a concern.

Summary

Rice Sh-Oligopeptide-1 is a lab-grown peptide from rice that tells skin cells to refresh themselves. By boosting natural turnover it helps soften fine lines, improve smoothness and support a healthy barrier, all while staying light and comfortable on the skin.

Although it is not the most talked about ingredient on store shelves, it has a loyal following in targeted serums, sheet masks and recovery creams where fast visible results are valued.

Current data shows a very low risk profile with only rare reports of irritation or allergy. As with any new skincare step, do a small patch test first to be sure your skin agrees.

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