Rice Sh-Polypeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Rice Sh-Polypeptide-1?

Rice Sh-Polypeptide-1 is a lab made copy of a natural human growth factor, but instead of being produced in a lab dish it is grown inside ordinary rice plants. Scientists insert a single human gene into the DNA of Oryza sativa so the plant starts making the same short chain of amino acids that our own cells would. After the rice is harvested the peptide is separated, filtered and purified until only the clean protein chain remains. Because the rice acts like a mini factory the final ingredient is free of animal material and has a very low risk of carrying germs.

The idea of using plant grown human peptides started showing up in skin care research in the early 2000s when companies looked for greener and cheaper ways to make complex proteins. Rice became a favorite host because it grows fast, needs little care and already has a long history in beauty rituals across Asia. Today this bioengineered peptide is found in products that try to mimic the skin’s own signals, especially formulas that focus on hydration and visible firmness.

You will mainly spot Rice Sh-Polypeptide-1 in light lotions, concentrated serums, sheet masks, overnight creams and eye treatments that target fine lines or a lack of bounce. It is also used in soothing gels made for sensitive or freshly exfoliated skin thanks to its gentle nature.

Rice Sh-Polypeptide-1’s Cosmetic Benefits/Uses

This ingredient pulls double duty inside a formula, helping both the product texture and the look of the skin.

  • Humectant – draws moisture from the air and holds it at the skin’s surface which helps keep skin feeling plump and supple while reducing dryness tightness
  • Opacifying – gives creams and lotions a soft, milky appearance which can make the product look richer and feel more luxurious without heavy oils
  • Skin Conditioning – supports a smoother softer surface by lightly coating the skin so it feels silkier and appears more even

Who Can Use Rice Sh-Polypeptide-1

Because this peptide is light, water based and free of oils it suits nearly every skin type including dry, oily, combination and mature skin. Sensitive skin usually tolerates it well thanks to its gentle nature and lack of fragrance, though extremely reactive skin should still stay alert for any new ingredient.

Rice Sh-Polypeptide-1 is made entirely inside rice plants with no animal input so it is considered suitable for vegans and vegetarians. The manufacturing process avoids animal testing in most regions that allow alternative safety methods, but check the brand’s policy if cruelty free status is important to you.

Current research shows no special risk for women who are pregnant or breastfeeding when the peptide is used on intact skin. This is not medical advice and anyone expecting or nursing should run all skin care choices past a qualified doctor to be on the safe side.

The ingredient does not make skin more sensitive to sunlight, so it can be used morning or night. It also plays nicely with common actives like niacinamide and hyaluronic acid, making it easy to fit into most routines.

Potential Side Effects/Adverse Reactions

Side effects and reactions to topical Rice Sh-Polypeptide-1 can vary from person to person. The points below list potential outcomes, but they are uncommon when the ingredient is used at the levels normally found in finished cosmetic products.

  • Mild redness or warmth especially on very sensitive skin
  • Temporary itching or tingling if applied to freshly exfoliated or broken skin
  • Allergic contact dermatitis in rare cases where someone is specifically allergic to the peptide or another formula component
  • Eye irritation if the product accidentally gets into the eyes

If any of these reactions occur stop using the product and consult a healthcare professional if symptoms do not quickly settle.

Comedogenic Rating

Rating: 0/5 – Rice Sh-Polypeptide-1 is a pure, water-soluble peptide without heavy oils or waxes that could clog pores. It sits lightly on the skin, absorbs quickly and leaves no greasy film, so it is classed as non-comedogenic.

This makes it generally safe for people who are prone to acne or breakouts.

Because the peptide is usually added at very low levels and rinses away easily during cleansing, it is unlikely to build up on the skin over time.

Summary

Rice Sh-Polypeptide-1 acts as a humectant, opacifying agent and skin conditioner. It attracts moisture to keep skin bouncy, lends a creamy look to formulas so they feel richer and smooths the surface for a softer feel. The peptide does all this while being light, oil free and vegan friendly.

Although not yet a household name, its eco-conscious production and gentle profile are helping it gain ground in modern serums, lotions and eye creams.

Safety data shows a very low risk of irritation or clogged pores, making it suitable for most skin types. As with any new skincare ingredient, patch testing a small area first is a smart move to confirm personal tolerance.

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