What Is Rice Sh-Polypeptide-9?
Rice Sh-Polypeptide-9 is a lab-designed version of Vascular Endothelial Growth Factor A, a protein naturally found in the human body. Scientists recreate its gene sequence, insert it into rice plants (Oryza sativa) through advanced breeding or a temporary expression system, then harvest the plants to extract the finished peptide. The result is a single-chain protein of up to 412 amino acids that may feature stabilizing disulfide bonds or sugar groups, giving it structure and resilience.
The idea of producing human-identical proteins in plants took off in the early 2000s when researchers sought cost-effective, animal-free ways to make growth factors for skin care. Rice quickly became a favorite “green factory” because it is easy to grow, well understood genetically and poses low allergen risk once purified. After isolation, the peptide is filtered, tested for purity and blended into cosmetic formulas.
You will mainly find Rice Sh-Polypeptide-9 in anti-aging serums, intensive moisturizers, sheet masks, post-procedure soothing gels and specialty eye or neck creams where brands want a lightweight yet potent skin revitalizer.
Rice Sh-Polypeptide-9’s Cosmetic Benefits/Uses
This peptide is valued for one key role in skin care formulations.
Skin conditioning: by mimicking a naturally occurring growth factor it signals surface cells to look healthier and feel smoother. Formulas that include it aim to boost hydration, refine texture and promote a fresher more radiant appearance, making the overall product feel more luxurious and effective.
Who Can Use Rice Sh-Polypeptide-9
Because it is lightweight and non-occlusive Rice Sh-Polypeptide-9 suits almost every skin type including oily dry combination and even sensitive skin that reacts to heavy textures. People with extremely reactive or barrier-impaired skin may still want to start slowly since any active protein can sometimes overstimulate fragile complexions.
The peptide is grown in rice rather than harvested from animals so it aligns with vegan and vegetarian lifestyles. No animal-derived materials are needed during production or purification.
Current research shows no specific risk for women who are pregnant or breastfeeding when the ingredient is used topically and in the low percentages found in cosmetics. That said this is not medical advice and anyone who is expecting or nursing should show the full ingredient list of a new product to a qualified doctor to be extra safe.
Rice Sh-Polypeptide-9 does not increase photosensitivity and it can be worn during the day with or without sun exposure. Standard daytime sunscreen use is still encouraged for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Rice Sh-Polypeptide-9 vary from person to person. The following are potential effects that could occur yet most users will not experience them when the ingredient is correctly formulated and preserved.
- Transient redness or mild warmth
- Itching or tingling at the application site
- Dry patches if paired with very strong exfoliants
- Allergic contact dermatitis in individuals sensitive to rice proteins or preservatives used alongside the peptide
- Eye irritation if the formula migrates into the eyes
- Increased flushing in skin already prone to active rosacea
If you notice any persistent discomfort swelling or rash stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0 / 5. Rice Sh-Polypeptide-9 is a large water-soluble protein with no oily or waxy parts that could block pores. It quickly dissolves into the water phase of a formula and easily rinses off the skin, leaving little chance of building up inside follicles.
Because of this profile it is generally considered safe for people who are prone to acne or breakouts.
Keep in mind that a finished product’s pore-clogging potential depends on the whole recipe. Heavy oils, butters or silicones used alongside the peptide could still trigger congestion even though the peptide itself does not.
Summary
Rice Sh-Polypeptide-9 is a plant-produced twin of human Vascular Endothelial Growth Factor A that conditions skin by telling surface cells to act younger, hold moisture better and look smoother. Brands slip it into serums, creams and masks to give a subtle boost in hydration and radiance without adding weight.
The ingredient sits in the “niche but growing” corner of the market. It shows up most often in mid to high-end formulas where companies can afford the biotech cost and want a vegan friendly talking point. You will not see it in every drugstore product yet its presence is slowly expanding as plant molecular farming becomes cheaper.
Topical use is considered low risk with very few reported reactions. As with any new cosmetic it is smart to perform a quick patch test the first time you try a product containing Rice Sh-Polypeptide-9, especially if your skin is sensitive or allergy-prone.