Rosmarinoyl Tetrapeptide-75: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Rosmarinoyl Tetrapeptide-75?

Rosmarinoyl Tetrapeptide-75 is a lab crafted complex that joins rosmarinic acid, a plant compound best known from rosemary leaves, with Tetrapeptide-75, a short chain of four amino acids. Rosmarinic acid lends natural antioxidant power while the peptide segment is valued for its skin friendly profile. The pairing was first explored by cosmetic chemists looking to merge plant actives with peptide technology for stronger results in age defense formulas. Production begins with the controlled extraction of rosmarinic acid from rosemary or other herb sources. The acid is purified, then reacted with a synthetically produced Tetrapeptide-75 in a water based medium under precise temperature and pH settings. Once bonded and stabilized, the finished ingredient is filtered, dried and added to cosmetic bases. You will usually spot it in lightweight serums, eye creams, moisturizers, sheet masks, firming concentrates and other leave-on treatments that aim to boost skin vitality.

Rosmarinoyl Tetrapeptide-75’s Cosmetic Benefits/Uses

This dual action ingredient supports formulas in two key ways:

  • Antioxidant: Helps neutralize free radicals created by daily exposure to sunlight and pollution which can dull tone and speed up visible aging. By curbing this oxidative stress the ingredient aids in keeping skin looking brighter and more even
  • Skin conditioning: Assists with maintaining a smooth soft surface feel. The peptide portion can support the skin’s own proteins, promoting a firmer appearance and a comfortable hydrated finish

Who Can Use Rosmarinoyl Tetrapeptide-75

This peptide–plant combo is generally suitable for all skin types including dry, balanced, combination, oily and mature complexions. Its lightweight texture and low irritancy profile make it friendly for sensitive skin as well, provided the finished formula is free of harsh fragrances or high alcohol content.

Because Rosmarinoyl Tetrapeptide-75 is produced from a botanical acid and a lab made peptide, with no animal derived substances involved, it is typically considered vegan and vegetarian friendly. Always check the full ingredient list to be sure the overall product meets personal ethical standards.

No specific warnings exist for pregnant or breastfeeding women, and the ingredient is not known to penetrate deeply or enter systemic circulation. That said, research during pregnancy is limited, so this information should not be taken as medical advice. Anyone expecting or nursing should review all skincare products with a qualified healthcare professional to stay on the safe side.

The ingredient itself does not trigger photosensitivity. In fact its antioxidant action may help offset some of the stress caused by sunlight, although it is never a substitute for broad-spectrum sunscreen. It layers well with common actives like niacinamide, hyaluronic acid, vitamin C and retinoids without reported conflicts.

Potential Side Effects/Adverse Reactions

Responses to any topical ingredient differ from person to person. The points below outline potential side effects that could occur with Rosmarinoyl Tetrapeptide-75, yet most users will not encounter them when the ingredient is formulated and used correctly.

  • Mild skin irritation such as stinging or burning on application
  • Transient redness
  • Localized itching
  • Allergic contact dermatitis in individuals sensitive to rosemary related compounds or certain peptides

If you notice any of these reactions, stop using the product immediately and consult a healthcare professional for guidance.

Comedogenic Rating

Rating: 0 / 5

Rosmarinoyl Tetrapeptide-75 is water soluble, has a low molecular weight and does not leave an occlusive film on skin, so it does not clog pores. Its peptide portion is easily absorbed while rosmarinic acid is naturally light and non greasy, resulting in virtually no comedogenic risk.

Because of this the ingredient is generally suitable for people prone to acne or breakouts.

Keep in mind that the overall formula matters: heavy oils, waxes or silicones used alongside this peptide could still cause congestion even if the active itself does not.

Summary

Rosmarinoyl Tetrapeptide-75 pairs antioxidant power from rosmarinic acid with the skin conditioning support of a tetrapeptide. Together they help neutralize free radicals, maintain a smooth resilient surface and encourage a brighter more even look.

The ingredient is still a niche choice, found mainly in newer serums and eye creams rather than mass market staples, yet interest is growing as brands look for gentle multitasking actives.

Current data shows it to be safe for most users with a very low irritation and comedogenic profile. As with any new skincare product a quick patch test is wise before full face application.

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