What Is S-Cutibacterium Acnes Oligopeptide-1?
S-Cutibacterium Acnes Oligopeptide-1 is a lab-made fragment of Foldase YidC, a protein naturally produced by the skin-dwelling bacterium Cutibacterium acnes. Scientists took a 14-amino-acid stretch of that larger 359-amino-acid protein and recreated it through solid-phase peptide synthesis, a method that builds the chain one amino acid at a time for high purity and batch-to-batch consistency. Because it is made synthetically there is no live bacteria in the final ingredient, making it both stable and suitable for a wide range of formulations.
The rise of microbiome-inspired skincare in the early 2010s encouraged researchers to look at bacterial proteins for skin benefits without the drawbacks of using whole microbes. This peptide emerged as part of that movement and has been adopted by formulators looking for gentle skin conditioners that mimic the skin’s natural environment. You will commonly find it in lightweight facial serums, hydrating essences, soothing post-cleansing mists, daily moisturizers and targeted anti-blemish or barrier-repair treatments where a calm balanced finish is desired.
S-Cutibacterium Acnes Oligopeptide-1’s Cosmetic Benefits/Uses
This ingredient is valued for one main purpose in cosmetics.
As a skin-conditioning agent, S-Cutibacterium Acnes Oligopeptide-1 helps maintain a soft smooth surface by supporting the skin’s natural moisture balance and reinforcing a comfortable feel. Its biomimetic design means it can sit gently on the skin, signaling a healthier environment without clogging pores or causing heaviness, which makes it suitable for both oily and sensitive complexions seeking a lightweight conditioning boost.
Who Can Use S-Cutibacterium Acnes Oligopeptide-1
This peptide suits most skin types because it is lightweight non occlusive and biomimetic. Oily and combination skin benefit from conditioning without extra heaviness while dry and mature skin appreciate the added softness. Sensitive or redness-prone skin generally tolerates it well thanks to its gentle nature. At this time there are no skin types that must avoid the ingredient unless an individual knows they are allergic to peptides in general.
S-Cutibacterium Acnes Oligopeptide-1 is created entirely through synthetic chemistry with no animal-derived inputs so it is considered vegan and vegetarian friendly.
Current data does not flag any specific risks for women who are pregnant or breastfeeding because the molecule is large enough to stay on the skin surface and is used at very low concentrations. This is not medical advice and anyone who is pregnant or nursing should review any skincare product with their physician to be safe.
The ingredient does not increase photosensitivity and can be used morning or night without raising the risk of sunburn. It also plays well under sunscreen and makeup.
Potential Side Effects/Adverse Reactions
Responses to topical S-Cutibacterium Acnes Oligopeptide-1 vary from person to person. The points below list potential side effects but they are unlikely for the average user when the product is formulated and stored correctly.
- Mild temporary redness or itching usually in people with very reactive skin
- Slight stinging or burning on application if the skin barrier is already compromised or if the formula has a very low pH
- Allergic contact dermatitis a rare immune response to the peptide or another ingredient in the same product
- Breakouts triggered by other components in the formulation although the peptide itself is considered non comedogenic
- Irritation from product spoilage if preservatives fail and bacteria grow in the container
If any of these effects occur stop using the product and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 0/5. S-Cutibacterium Acnes Oligopeptide-1 is a small water-soluble peptide that sits on the skin surface without forming an occlusive film or altering sebum flow, so it does not trap oils or debris in pores. It is used at very low percentages, is free of heavy oils or waxes, and breaks down readily in water-based formulas, all of which keep its clogging potential negligible. This makes it perfectly suitable for acne- and breakout-prone skin. Because the peptide relies on the surrounding formula for texture and stability, only a product packed with highly comedogenic co-ingredients would change that rating.
Summary
S-Cutibacterium Acnes Oligopeptide-1 is a lab-engineered 14-amino-acid fragment that conditions skin by mimicking a friendly bacterial protein, helping skin feel softer and better balanced. It works by lightly interacting with the uppermost layers, supporting moisture retention and promoting a calmer surface without weight or grease.
The peptide sits in the niche world of microbiome-inspired actives so it is not yet as common as classics like hyaluronic acid, but formulators looking for gentle barrier support and buzzworthy technology are beginning to adopt it in serums and lightweight creams.
Safety data so far show a low risk profile with minimal irritation reports, no known photosensitivity and no animal-derived components. As with any new skincare ingredient though it is smart to patch test a fresh product first to rule out individual sensitivity.