What Is S-Hiv-1 Oligopeptide-7 Sh-Oligopeptide-1 Sp?
S-Hiv-1 Oligopeptide-7 Sh-Oligopeptide-1 Sp is a lab-engineered chain of 76 amino acids that merges two synthetic peptides: s-Hiv-1 Oligopeptide-7 and sh-Oligopeptide-1 Sp. Because it is created entirely in a controlled environment, it is classed as a bio-identical peptide rather than an extract from plants or animals. Researchers first explored this type of peptide while studying how short sequences of amino acids could mimic growth factors that encourage healthier looking skin. Once their skin-supporting potential became clear, formulators began adding them to premium skin care in the early 2000s.
The manufacturing process centers on solid-phase peptide synthesis, a step-by-step method that links amino acids in a pre-set order. After assembly the peptide is purified, filtered and freeze-dried into a stable powder that is easy to dissolve into water-based products. Because it is water-soluble it blends smoothly into serums, sheet masks, lightweight lotions, concentrated anti-aging ampoules and soothing after-sun gels. Brands often highlight it in products aimed at improving skin tone, supporting barrier strength and reducing the visible signs of daily stress.
S-Hiv-1 Oligopeptide-7 Sh-Oligopeptide-1 Sp’s Cosmetic Benefits/Uses
This peptide offers two main functions that work together to keep skin looking and feeling its best.
- Skin conditioning – helps skin feel softer and more supple by supporting natural hydration levels and encouraging a smoother surface appearance
- Skin protecting – supports the skin’s barrier so it can better defend against environmental stress like pollution and seasonal changes which, in turn, helps reduce visible dryness and dullness
Who Can Use S-Hiv-1 Oligopeptide-7 Sh-Oligopeptide-1 Sp
This lab made peptide is lightweight and water soluble so it generally suits normal, dry, oily and combination skin. It is also considered low risk for sensitive skin because it does not contain common allergens or fragrances, though anyone with a history of peptide sensitivities should proceed with caution.
Because the peptide is produced entirely through synthetic chemistry and contains no animal sourced material it is suitable for vegans and vegetarians. Always confirm that the finished product has not been tested on animals if that is an additional concern.
The molecule is quite large which limits its ability to penetrate deeply into the bloodstream. For that reason most experts view topical use during pregnancy or while breastfeeding as low concern, but this is not medical advice. Pregnant or nursing individuals should review any skincare routine with a qualified healthcare professional.
S-Hiv-1 Oligopeptide-7 Sh-Oligopeptide-1 Sp is non photosensitizing so it will not make skin more prone to sunburn. Daily sunscreen is still recommended to protect overall skin health. The peptide also plays nicely with common actives like niacinamide, hyaluronic acid and ceramides which makes it easy to layer within existing routines.
Potential Side Effects/Adverse Reactions
Responses to topical S-Hiv-1 Oligopeptide-7 Sh-Oligopeptide-1 Sp differ from person to person. The points below outline potential side effects that have been reported, though they are rare when products are correctly formulated and used as directed.
- Mild redness or warmth at the application site
- Temporary itching or tingling
- Localized rash or hives indicating an allergic reaction
- Swelling in very sensitive individuals
- Breakouts if the overall formula is too occlusive for the user’s skin
If any irritation or unusual reaction occurs stop using the product immediately and seek advice from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0 out of 5. S-Hiv-1 Oligopeptide-7 Sh-Oligopeptide-1 Sp is a large, water-soluble peptide with no oily or waxy carriers, so it does not lodge inside pores or mix with sebum in a way that could trigger blockages. Because it stays on the skin surface and rinses away cleanly, its chance of clogging pores is considered negligible.
That makes the ingredient generally suitable for people who are prone to acne or frequent breakouts.
Keep in mind that the overall formula matters too. If the peptide appears in a thick, heavy cream the final product could still feel greasy and occlusive even though the peptide itself is non-comedogenic.
Summary
S-Hiv-1 Oligopeptide-7 Sh-Oligopeptide-1 Sp works as a skin-conditioning and skin-protecting agent. By mimicking naturally occurring growth factors it helps the skin hold moisture, smooths surface texture and supports the barrier so it can better fend off everyday stress.
You will mostly find this peptide in higher-end serums, ampoules and sheet masks. It is gaining traction but remains a niche addition compared with household names like hyaluronic acid or niacinamide.
Safety data show a low risk of irritation, allergy or pore clogging, making it a well-tolerated option for most skin types. As with any new product, performing a quick patch test is a smart step before full-face use.