S-Pea Oligopeptide-1 Sp: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is S-Pea Oligopeptide-1 Sp?

S-Pea Oligopeptide-1 Sp is a lab crafted fragment of a protein first identified in the common pea, Pisum sativum. Scientists copied part of the plant enzyme linoleate 9S lipoxygenase-3, creating a single-chain peptide of up to 861 amino acids that may naturally fold into shapes held together by tiny sulfur bridges or sugar links. Because it is produced in fermenters using biotechnology instead of harvested crops, every batch is vegan, highly pure and uniform in quality.

Interest in plant peptides for skin care rose in the early 2000s when researchers saw how gently they conditioned skin. Pea peptides attracted attention for their mild nature and soon found a place in moisturizers and age-defying products as an alternative to animal derived proteins.

The production process starts with inserting a DNA template for the desired amino acid sequence into yeast or bacteria. These microorganisms then ferment, building the peptide inside a controlled tank. After fermentation the peptide is filtered, purified and dried into a fine powder that dissolves easily in water-based formulas.

Formulators add S-Pea Oligopeptide-1 Sp to sheet masks, lightweight serums, daily moisturizers, eye creams and targeted firming treatments where a protein boost can improve skin feel.

S-Pea Oligopeptide-1 Sp’s Cosmetic Benefits/Uses

In skin care S-Pea Oligopeptide-1 Sp plays one main role

Skin conditioning: it forms a thin, breathable layer that helps skin feel smoother, softer and better hydrated. By mimicking natural skin proteins it supports a fresh appearance, reinforces the surface barrier and leaves a silky finish that enhances makeup glide.

Who Can Use S-Pea Oligopeptide-1 Sp

S-Pea Oligopeptide-1 Sp is considered friendly for all major skin types including normal, dry, combination, oily and sensitive. Because it is a lightweight water-soluble peptide that simply coats the surface it rarely clogs pores or leaves a greasy residue, making it a safe pick even for acne-prone skin. There are no known reasons to avoid it on any particular skin type; however, people with a history of allergies to pea derivatives should proceed with caution.

The ingredient is produced entirely through biotechnology without any animal-derived raw materials so it is suitable for vegans and vegetarians.

Current data show no specific risks for pregnant or breastfeeding women. As with any cosmetic ingredient this is not medical advice and people who are expecting or nursing should discuss new skincare products with a healthcare professional before use just to be safe.

S-Pea Oligopeptide-1 Sp does not increase photosensitivity so it can be worn day or night without raising the risk of sunburn. Standard daily sunscreen use is still recommended for overall skin health.

Potential Side Effects/Adverse Reactions

Responses to topical S-Pea Oligopeptide-1 Sp can vary from person to person. The following list covers potential side effects, though most users will not encounter them when the ingredient is properly formulated and applied:

  • Mild redness or warmth small areas may appear flushed shortly after application but usually settle quickly
  • Stinging or itching transient tingling can occur especially on compromised skin
  • Dry patches very sensitive skin may feel tight if the formula lacks sufficient moisturizers
  • Contact dermatitis rare allergic reactions can lead to rash swelling or flaking
  • Ingredient instability with strong acids combining high concentrations of alpha or beta hydroxy acids may degrade the peptide and provoke irritation

If irritation or any unwanted reaction develops discontinue use and seek advice from a qualified healthcare professional.

Comedogenic Rating

Rating: 0 out of 5

S-Pea Oligopeptide-1 Sp is a large water-soluble peptide that sits on the surface then rinses away easily, so it is very unlikely to mix with skin oils or block pores. It has no fatty chains or waxy fillers that would normally raise the risk of congestion.

Because of this, the ingredient is generally considered safe for people who are prone to acne or frequent breakouts.

One extra point worth noting is that comedogenicity also depends on the full formula. If the product pairing the peptide includes heavy butters or thick silicones, the overall pore-clogging risk can rise even though the peptide itself remains non-comedogenic.

Summary

S-Pea Oligopeptide-1 Sp is a lab-made pea peptide used mainly for skin conditioning. It forms a thin breathable layer that helps skin feel smooth, soft and hydrated while supporting the surface barrier for a fresher look. Thanks to its plant origin, clean production and gentle action it has gained a quiet but growing following in serums masks and light moisturizers, though it is not yet as widespread as collagen or hyaluronic acid.

Current data show the peptide to be low risk with very few reports of irritation or allergy. As with any new skin care ingredient it is wise to patch test a product before adding it to your daily routine just to be safe.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search