S-Rice Oligopeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is S-Rice Oligopeptide-1?

S-Rice Oligopeptide-1 is a lab-made fragment of a larger rice protein called starch synthase. Scientists copy just 11 of the original amino acids, keeping the part that is thought to be most helpful for skin care. Because it is created in controlled conditions rather than extracted from crops, the peptide is consistent, pure and vegan friendly.

Interest in rice-derived peptides began when researchers noticed how rice water was traditionally used to soften and brighten skin. Over time, technology advanced enough to isolate the most active chains, leading to today’s synthetically produced S-Rice Oligopeptide-1. It first appeared in niche Asian beauty lines, then expanded into global products once its stability and gentle nature were confirmed.

Production starts with fermenting plant-based raw materials to get the exact amino acid sequence. This short chain is then purified, dried and blended into a water-soluble powder that slips easily into cosmetic formulas without changing their look or feel.

You will spot S-Rice Oligopeptide-1 in lightweight serums, sheet masks, anti-aging creams, hydrating gels and eye treatments where brands want a mild but effective active that also improves product texture.

S-Rice Oligopeptide-1’s Cosmetic Benefits/Uses

This peptide offers two main functions that support both skin health and the overall quality of a formula.

  • Antioxidant – helps neutralize free radicals created by pollution and UV exposure which can make skin look dull and tired. Regular use may defend against early signs of aging such as fine lines and uneven tone.
  • Bulking – adds body to a product so lotions feel more cushiony and serums pour smoothly. This can improve spreadability, giving users an even application without greasy residue.

Who Can Use S-Rice Oligopeptide-1

S-Rice Oligopeptide-1 suits most skin types including dry, balanced, oily and sensitive because it is a small, skin-friendly peptide that rarely disrupts the barrier or clogs pores. Those with very reactive or highly compromised skin can still proceed with caution but the ingredient itself is considered gentle.

The peptide is made in a lab from plant-derived building blocks so it contains no animal material, making it appropriate for vegans and vegetarians.

No research links S-Rice Oligopeptide-1 to hormonal activity or systemic absorption, so products containing it are generally viewed as safe for pregnant or breastfeeding women. This is not medical advice and anyone who is expecting or nursing should run new skincare by a doctor just to be sure.

S-Rice Oligopeptide-1 does not increase photosensitivity and can be used morning or night without raising the risk of sunburn. Standard daytime SPF is still recommended.

The peptide is water soluble and works well alongside common actives like niacinamide or hyaluronic acid, though pairing it with very high or very low pH products could reduce its stability.

Potential Side Effects/Adverse Reactions

Side effects from topical S-Rice Oligopeptide-1 vary from person to person. The points below list potential reactions but most users will not experience them when the ingredient is formulated and used correctly.

  • Mild redness or warmth
  • Temporary itching or tingling
  • Localized irritation for those with a rice allergy
  • Rare contact dermatitis if combined with other strong actives
  • Breakouts in acne-prone skin if the overall product base is too heavy

If any negative reaction occurs stop use immediately and seek advice from a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0 / 5. S-Rice Oligopeptide-1 is a tiny water-soluble peptide that brings no oils waxes or heavy fillers to a formula so it does not sit inside pores or form a film that traps dead skin. For that reason it is considered non-comedogenic and safe for skin that breaks out easily. Because the ingredient is often blended into lightweight serums or gels any clogging risk usually comes from other thick components in the product rather than the peptide itself.

Suitable for acne-prone users.

Keep in mind that overall formula design, added fragrances or rich butters can still cause congestion even if the peptide is clear of that issue.

Summary

S-Rice Oligopeptide-1 works as an antioxidant that helps mop up free radicals created by pollution and sunlight. It also acts as a bulking agent giving creams and serums a smooth cushioned feel. It pulls off both jobs because the lab-made 11-amino-acid chain is stable, water friendly and small enough to blend evenly through a product without separating.

The peptide is gaining attention in modern K-beauty and clean beauty lines though it is not yet as mainstream as classics like vitamin C or retinol. Brands that want gentle vegan actives are starting to add it to anti-aging and glow formulas so you can expect to see it pop up more often.

Current safety data shows low irritation risk, no links to hormone disruption and no comedogenic issues. Still it is smart to patch test any new skincare to make sure your individual skin stays happy.

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