Saccharide Isomerate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Saccharide Isomerate?

Saccharide Isomerate is a plant derived mixture of sugars created by rearranging glucose molecules, most often sourced from corn. Through an enzymatic process called isomerisation the sugars are converted into a structure that closely matches the carbohydrates found naturally in human skin, especially those that make up the Natural Moisturizing Factor.

First explored by chemists in the late 1970s it quickly found a place in skin care as a dependable moisturizer that keeps working even after rinsing. Production starts with purified plant glucose, which is treated with specific enzymes under controlled temperature and pH, then filtered and concentrated into a clear water soluble liquid that is easy to add to cosmetic formulas.

Because of its strong affinity with skin it appears in many leave on products such as daily moisturizers, anti aging serums, sheet masks, eye creams and soothing after sun gels. You can also spot it in rinse off items like shampoos and conditioners where it helps hair feel hydrated.

Saccharide Isomerate’s Cosmetic Benefits/Uses

This ingredient is prized for one main function that delivers a noticeable benefit to both products and skin.

As a humectant Saccharide Isomerate attracts and binds water to the surface of the skin. This helps keep skin hydrated for long periods, reduces the feeling of tightness and makes the complexion look smoother and plumper. Because it bonds so well with the skin it continues to draw moisture even after washing, which can improve the overall performance of a formula and offer lasting comfort to dry or sensitive skin.

Who Can Use Saccharide Isomerate

Saccharide Isomerate is considered friendly for all skin types. Dry and dehydrated skin benefit most from its strong moisture binding ability while oily and combination skin like it because it adds water without a greasy feel. Sensitive skin generally tolerates it well since it is non volatile and has a low risk of causing redness or stinging.

The ingredient is plant derived, commonly from corn, and contains no animal by-products so it is suitable for both vegans and vegetarians. Certification may vary by brand so anyone following a strict lifestyle should check for a confirmed vegan label.

Current safety data shows no issues for people who are pregnant or breastfeeding. Still this is not medical advice and anyone who is expecting or nursing should review any new skincare product with a healthcare professional first to be safe.

Saccharide Isomerate does not make skin more sensitive to sunlight so there is no added need for extra sun protection beyond the usual daily SPF recommendation.

Potential Side Effects/Adverse Reactions

Reactions to topical Saccharide Isomerate can differ from one individual to another. The effects listed below are possible but unlikely for most users when the ingredient is included at normal cosmetic levels.

  • Mild redness or irritation in very sensitive skin
  • Allergic contact dermatitis indicated by itching or rash
  • Temporary stinging on compromised or freshly exfoliated skin
  • Sticky feel if a product contains an unusually high concentration

If any of these problems occur stop using the product and consult a medical professional if symptoms persist or worsen.

Comedogenic Rating

Rating: 0 / 5 – Non-comedogenic

Saccharide Isomerate is a small, water soluble sugar complex that sits on the surface of skin without clogging pores or leaving an occlusive film. It contains no oils or fatty acids that could trap sebum, so it earns the lowest possible score on the comedogenic scale.

This makes it a safe choice for people who are prone to acne or breakouts. Because it pulls water into the skin rather than adding oil it can even help balance an oily complexion.

Formulators often pair it with light gel textures or oil-free lotions, keeping the overall product friendly to congested or reactive skin.

Summary

Saccharide Isomerate is a plant derived humectant that binds water strongly to the skin surface, delivering lasting hydration, smoothing fine lines and easing dryness. It performs by mimicking the skin’s own Natural Moisturizing Factor, creating an affinity that keeps moisture locked in even after rinsing.

Over the past decade its popularity has risen steadily, showing up in a wide range of moisturizers, serums and hair care products because formulators value its rinse-resistant boost of hydration.

Current research and consumer use reports rate it as a very safe ingredient with minimal risk of irritation or allergy at typical levels. As with any new skincare addition though it is wise to patch test a product first to confirm personal compatibility.

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