Santaliff: The Complete Guide To This Aroma Chemical

Curious about this ingredient? In this article we're explaining everything you need to know.
Updated on: July 29, 2025
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We verify all information on this page using publicly available standards from The International Fragrance Association (IFRA) and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Santaliff?

Santaliff is a modern aroma molecule created by International Flavors & Fragrances, better known as IFF. It was developed to give perfumers an eco-conscious way to add a rich sandalwood signature without resorting to natural sandalwood oil, whose supply is both limited and tightly regulated. While IFF holds the trademark, other fragrance suppliers often offer comparable molecules under alternate trade names, so you may come across equivalents on the market.

The material starts life as renewable feedstock that would otherwise be discarded in the food chain. Through a series of green chemistry steps the raw material is cleaned up, refined and distilled until it becomes a pure liquid aroma chemical with the formula C13H22O. At room temperature it looks like water with a very faint golden hue, remaining fluid and clear even in cooler labs.

Santaliff is already popular in fine fragrance, fabric conditioner and soap because it keeps its character through the wash cycle and survives most manufacturing temperatures. A sealed drum stored in a cool dark warehouse will usually stay within spec for roughly two to three years before the scent starts to thin out.

From a cost point of view Santaliff sits in the mid range. It is markedly cheaper than genuine Mysore sandalwood oil yet more expensive than the most basic synthetic woods, making it a sensible everyday choice for brands aiming for a creamy sandalwood effect without inflating the formula cost.

Santaliff’s Scent Description

Perfumers place Santaliff firmly in the woody family. On a blotter its scent opens with a silky cloud of sandalwood that feels both clean and comforting. Very quickly a milky facet appears, similar to warm coconut milk, which softens any sharp edges. As the minutes pass a subtly sweet cream note joins in, giving the wood a velvety depth rather than a dry plank-like impression. Underneath is a faint hint of cedar and the barest trace of spice, adding dimension without calling attention to themselves.

Fragrances are often described in terms of top, heart and base notes. Top notes greet you first and evaporate fast, middle notes form the main body while base notes linger the longest. Santaliff behaves almost like a bridge spanning all three layers. You can detect it early on yet it truly blooms in the heart, and thanks to its low volatility it anchors the dry-down for hours.

When used at a typical level its projection is moderate so it envelops the wearer rather than shouting across a room. Longevity is impressive: on a blotter the scent can still be smelled clearly after two or even three days, making it a reliable fixer for lighter materials in a formula.

How & Where To Use Santaliff

Perfumers reach for Santaliff when they want a sandalwood tone that lasts, behaves predictably and sits at a mid tier cost. It shines as the backbone of a woody or gourmand sandalwood accord, where it provides creamy volume that rounds off sharper cedars or dry vetiverts. In compositions built around florals it helps bridge the gap between a luminous top and a musky base, creating a soft milky cushion beneath rose, jasmine and ylang.

Because it projects from the very first spray yet stays detectable for days, Santaliff can replace part of the natural sandalwood oil quota or bolster it when supply is tight. Perfumers often compare it to fellow sandalwood substitutes such as Javanol or Sandalore; Santaliff’s profile is less metallic than Javanol and less sheer than Sandalore, so it is chosen when a creamier, more natural impression is needed.

Typical usage levels run from a trace amount for subtle warmth up to 5 % of the concentrate for a pronounced woody statement. At very low doses it adds a quiet creamy halo that most smellers cannot pick out as a note but notice when it is removed. Around 1 % to 2 % it becomes recognisably sandalwood, enriching lactonic notes and smoothing rough edges. Above 4 % it can dominate, pushing the blend toward a heavy dairy-like woodiness that risks feeling waxy or flat, especially in delicate citrus fragrances.

Application wise it performs excellently in fine fragrance and fabric conditioners, very well in soaps and acceptably in powder detergents. High pH laundry powders can dull its creamy nuance so many perfumers compensate by pairing it with coumarin or Iso E Super for lift. Its low vapor pressure means it lingers on blotters and fabric, a plus for longevity but a drawback in reed diffusers where more volatile woods are preferred.

Before weighing Santaliff many labs warm the bottle slightly or pre dilute it to 10 % in dipropylene glycol or ethanol to improve flow and dosing accuracy. Always mix it thoroughly since its high molecular weight slows down homogenisation. Keep pipettes dedicated to woody materials to avoid cross contamination with delicate citrus or green notes.

Safely Using Santaliff

Dilution is key when evaluating Santaliff. Always create a working solution before smelling to prevent sensory fatigue or accidental skin contact with the neat material. Avoid direct sniffing from the bottle. Work in a well ventilated space so any vapours disperse quickly and place the strip at arm’s length when assessing. Gloves and safety glasses protect skin and eyes from splashes during weighing or dilution.

Like many aroma chemicals Santaliff can provoke irritation or sensitisation in some people, especially after repeated exposure. If you are pregnant or breastfeeding consult a healthcare professional before handling fragrance materials. Brief contact with low concentrations is usually tolerated but prolonged work with the undiluted liquid or inhalation of high levels should be avoided.

Should the material touch skin wash with plenty of soap and water. In case of eye contact rinse immediately and seek medical advice if discomfort persists. Never ingest fragrance ingredients and keep containers sealed and clearly labelled to avoid confusion.

For large scale work store Santaliff in a cool, dark place in tightly closed aluminium or amber glass to slow oxidation. Small residues or expired stock can be combined with absorbent material and disposed of in accordance with local chemical waste regulations rather than poured down a drain.

Always consult the most recent safety data sheet supplied by your vendor and follow any regional regulations. Check the International Fragrance Association guidelines for maximum allowable levels in the end product and review both documents regularly as updates are common.

How To Store & Dispose of Santaliff

Keep Santaliff in a tightly closed bottle placed in a cool dark cupboard away from sunlight and sources of heat. Refrigeration is not required but can help you stretch the shelf life past the usual two year guideline. If you chill it, allow the bottle to return to room temperature before opening so moisture does not condense inside.

Use bottles fitted with polycone caps for both neat stock and dilutions. These caps form a snug seal that slows air exchange and stops leaks. Avoid glass dropper bottles because the rubber bulbs let oxygen slip in and can taint the scent.

Try to store the material in containers that are as full as possible. Less headspace means less oxygen and that lowers the chance of oxidation which can dull the creamy sandalwood note. Decant leftovers into smaller bottles rather than leave a large one half empty.

Label every container clearly with the name Santaliff, its CAS 28219-60-5, date received and any safety icons recommended on the SDS. Good labeling prevents mix-ups and reminds anyone who handles the bottle to wear gloves and goggles.

Santaliff is readily biodegradable so small lab spills can be wiped up with paper towel then thrown in general trash if local rules permit. Larger volumes or expired stock should be mixed with an inert absorbent like cat litter and disposed of through a licensed chemical waste provider. Never pour it down the sink because fragrance oils can still stress waterways.

Summary

Santaliff is an IFF aroma molecule that delivers a smooth creamy sandalwood impression with strong staying power. It fits into woody blends, floral foundations and gourmand accords where it gives body, warmth and lasting projection.

Perfumers value it because it is stable, mid-priced and free of the sourcing issues tied to natural sandalwood oil. It performs best in fine fragrance, soap and fabric conditioners though it needs a little help to shine in high pH powders.

Remember to store it cool and well sealed, pre-dilute for easy dosing and keep usage between a trace and 5 percent depending on how loud you want the woodiness to speak.

Commercial quantities come direct from IFF or through distributors that handle bulk aroma chemicals. Hobbyists can find smaller amounts from third-party resellers or generic makers who list the same CAS number, making Santaliff accessible whether you run a lab or mix at home.

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