What Is Sh-Oligopeptide-104 Sp?
Sh-Oligopeptide-104 Sp is a lab made mini-protein made of 19 amino acids. Scientists designed it to match a small slice of a larger human protein called DKC1, which is found in skin cells. Because it is produced entirely in controlled laboratory settings, there is no animal or plant extraction involved, which keeps the final ingredient consistent and pure.
The peptide is built through a process called solid-phase synthesis. In simple terms, individual amino acids are linked together one by one in the correct order, then the finished chain is cleaned and tested for quality. This precise assembly lets chemists avoid the natural variations that come with animal or plant sources.
Peptides like this started to appear in skin care during the early 2000s, when research showed that small, targeted protein fragments could signal skin cells to behave in a healthier way. As more testing confirmed their safety and stability, brands began adding them to formulas aimed at boosting hydration and supporting a youthful look.
Today you can find Sh-Oligopeptide-104 Sp in lightweight serums, sheet masks, concentrated anti-aging treatments, daily moisturizers, eye creams and even some hydrating facial mists. Its small size allows it to blend easily into water-based systems without changing the texture of the final product.
Sh-Oligopeptide-104 Sp’s Cosmetic Benefits/Uses
This peptide serves one main role in skin care formulas.
As a humectant, Sh-Oligopeptide-104 Sp draws water from the environment and from the deeper layers of skin toward the surface. This boost in moisture helps skin feel softer and look plumper which can temporarily smooth the appearance of fine lines. Because it keeps water locked in, it also supports the skin’s natural barrier making the complexion appear fresh and well hydrated.
Who Can Use Sh-Oligopeptide-104 Sp
Sh-Oligopeptide-104 Sp is gentle enough for most skin types. Dry and dehydrated complexions benefit most because the peptide acts like a water magnet but normal, combination and oily skin can also use it without a greasy feel. It is low weight and water soluble so it does not clog pores making it a good option for acne-prone skin. Those with very reactive or compromised skin should still introduce it slowly in case other formula components cause irritation.
The ingredient is produced entirely through synthetic chemistry with no animal derived raw materials or by-products so it is suitable for both vegans and vegetarians.
No evidence currently shows that this peptide poses special risks to women who are pregnant or breastfeeding when used topically and in the small amounts found in cosmetic products. This is not medical advice and anyone who is expecting or nursing should discuss all skin care choices with a qualified healthcare provider just to be safe.
Sh-Oligopeptide-104 Sp does not trigger photosensitivity and can be used morning or night. Standard daytime sun protection is still recommended because ultraviolet light is a major contributor to skin aging.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Oligopeptide-104 Sp differ from person to person. The points below list potential but unlikely side effects when the ingredient is included at normal cosmetic levels.
- Temporary redness or warmth at the application site
- Mild itching or tingling as the product dries
- Localized irritation if the formula contains high levels of other active ingredients
- Rare allergic contact dermatitis in individuals sensitive to specific amino acid sequences or preservatives used alongside the peptide
- Breakouts if the finished product includes heavy occlusive oils that do not suit acne-prone skin
If any persistent discomfort swelling or rash develops discontinue use and seek guidance from a healthcare professional.
Comedogenic Rating
Comedogenic rating: 0
Sh-Oligopeptide-104 Sp is a small water-soluble peptide with no oils, waxes or heavy emollients attached to its structure, so it does not form a film that could trap dead cells or sebum inside pores. Because it readily rinses away with water and mixes into lightweight formulas, it poses virtually no risk of blocking follicles. For that reason it is considered non-comedogenic and is generally safe for people who struggle with acne or frequent breakouts.
One thing to keep in mind: the finished product matters. If the peptide is blended into a rich balm or a formula loaded with pore-clogging oils, that product could still cause congestion even though the peptide itself will not.
Summary
Sh-Oligopeptide-104 Sp is a lab crafted 19-amino-acid fragment that works as a humectant, meaning it pulls moisture from the environment and from deeper skin layers toward the surface. By boosting water content it leaves skin feeling softer and looking plumper which can temporarily blur fine lines and support a healthy barrier.
The peptide is not yet a household name, but its clean manufacturing process, vegan status and ease of formulation have made it a quiet favorite among indie brands looking for gentle hydration boosters.
Current data shows it is well tolerated by most skin types with minimal risk of irritation or pore clogging. That said, every formula is different so performing a small patch test before full use is always a smart habit when trying any new skin care product containing this or any other active ingredient.