What Is Sh-Oligopeptide-13?
Sh-Oligopeptide-13 is a lab-made version of a small human protein originally linked to the body’s immune response. Scientists duplicate the gene that codes for the natural protein, insert it into friendly strains of E. coli, then let the bacteria ferment in controlled tanks. After the peptide is produced the mixture is purified so that only the desired chain of up to 92 amino acids remains. The result is a clean, single-chain peptide that can include natural links like disulfide bonds or small sugar groups.
Interest in skin-care peptides grew in the early 2000s when brands looked for gentler ways to support firm, smooth skin. Because Sh-Oligopeptide-13 is identical to a human sequence and can be made in large batches without animal material it quickly earned a place in cosmetic labs. Today you can find it in anti-aging serums, repairing night creams, sheet masks, soothing post-procedure gels, hydrating eye treatments and premium moisturizers that promise improved texture and resilience.
Sh-Oligopeptide-13’s Cosmetic Benefits/Uses
This peptide is valued for one key role in skin care.
As a skin-conditioning agent Sh-Oligopeptide-13 helps keep the surface of the skin soft, smooth and healthy looking. By supporting the skin’s natural renewal signals it can encourage a fresher appearance, boost hydration retention and reduce the look of rough patches, which is why formulators add it to products aimed at firmer, more even-toned skin.
Who Can Use Sh-Oligopeptide-13
Because it is a lightweight peptide with no added oils or fragrances, Sh-Oligopeptide-13 is generally well tolerated by all skin types including dry, oily, combination and sensitive skin. People with very reactive skin usually handle it well since the molecule is bio-identical to a natural human protein and is used at low concentrations.
The peptide is produced by fermenting genetically engineered E. coli and no animal-derived materials are introduced at any point in the process, making it suitable for vegans and vegetarians.
Current research shows no specific risks for pregnant or breastfeeding women when the peptide is used topically, but data are limited. This information is not medical advice and anyone who is expecting or nursing should ask their physician before adding a new cosmetic product to their routine.
Sh-Oligopeptide-13 is not known to increase photosensitivity, so it does not make skin more prone to sunburn. Normal daily sunscreen use is still recommended as part of a complete skincare regimen.
The ingredient plays well with most actives including retinoids, vitamin C and alpha hydroxy acids, so formulators can layer it without major stability or efficacy concerns.
Potential Side Effects/Adverse Reactions
Side effects from topical Sh-Oligopeptide-13 vary from person to person. The following list covers potential reactions but most users will not encounter these issues when the ingredient is formulated and used correctly.
- Mild redness or warmth at the application site
- Temporary stinging or tingling, especially on compromised or freshly exfoliated skin
- Itchiness in individuals with very sensitive skin
- Rare cases of allergic contact dermatitis
- Isolated reports of small breakouts in people prone to acne when used in heavy cream bases
If any of these reactions develop discontinue use immediately and seek guidance from a qualified healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Sh-Oligopeptide-13 is a water-soluble peptide with no fatty acids, oils or waxy carriers that could clog pores. It is normally used at very low concentrations, so it does not leave a residue that traps sebum or debris. Because of this it earns the lowest possible comedogenic score.
Suitable for acne-prone and breakout-prone skin.
Only the finished formula can change pore-clogging potential, so if the peptide sits in a rich, heavy cream the overall product might still trigger bumps for very oily skin types.
Summary
Sh-Oligopeptide-13 is a lab-crafted human-identical peptide that conditions skin by supporting its natural renewal signals, helping it feel smoother, better hydrated and more resilient. Though not as famous as peptides like Matrixyl or copper tripeptides, it appears more often in higher-end serums and recovery products where a gentle, bio-identical approach is desired.
Current evidence shows it is safe for most users, with very low risk of irritation or pore blockage when used in well-formulated products. As with any new skincare ingredient it is wise to patch test first to confirm personal compatibility.