What Is Sh-Oligopeptide-22 Sp?
Sh-Oligopeptide-22 Sp is a lab crafted fragment of the human chemokine TECK, a short chain of amino acids that naturally helps guide immune cells. In cosmetics the peptide is made through controlled fermentation: harmless bacteria receive the genetic code for TECK, produce the peptide, then technicians purify and filter it into a clear, water based concentrate.
Interest in chemokine inspired peptides for beauty care began in the early 2010s when researchers saw their potential to send gentle repair signals to skin cells. After safety reviews Sh-Oligopeptide-22 Sp found its way into premium skincare lines as a supporting ingredient that promotes softness and resilience.
You will now spot it in leave on products such as serums, anti aging lotions, sheet masks, eye creams and post peel soothing gels, usually at low concentrations alongside humectants and antioxidants.
Sh-Oligopeptide-22 Sp’s Cosmetic Benefits/Uses
In a topical formula Sh-Oligopeptide-22 Sp serves one key role: skin conditioning. By mimicking the body’s own signaling molecules it helps the surface feel smoother, appear more refreshed and recover quicker after daily stress, giving formulators a gentle tool to enhance comfort and support a hydrated healthy finish.
Who Can Use Sh-Oligopeptide-22 Sp
This lab made peptide is considered gentle enough for all skin types. Dry or mature complexions appreciate its conditioning feel, oily or acne prone skin benefits from its light water based format and sensitive skin usually tolerates it thanks to the lack of fragrance or harsh solvents. There are no known issues for darker or lighter skin tones.
Because the peptide is grown in harmless bacteria and purified without animal derived materials it is generally suitable for vegans and vegetarians. Always check the finished product label though, as other ingredients in the formula might not meet the same standard.
Current safety data shows no specific risks for pregnant or breastfeeding women using products containing Sh-Oligopeptide-22 Sp. Still, research in this area is limited so this is not medical advice. Anyone expecting or nursing should discuss new skincare with a qualified healthcare professional before use to be safe.
The ingredient does not increase photosensitivity and has no known contraindications with common actives such as vitamin C, niacinamide or retinoids. It can be used morning or night without special sun precautions beyond the usual daily SPF.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Oligopeptide-22 Sp differ from person to person. The points below outline potential side effects that could occur, yet they are uncommon when the ingredient is included at typical cosmetic levels and formulated correctly.
- Transient redness or warmth may appear right after application, especially on very reactive skin
- Mild itching can occur if the formula contains high levels of acids or alcohol alongside the peptide
- Contact dermatitis is rare but possible if an individual is allergic to any component in the final product
- Eye irritation can develop if the product accidentally gets into the eyes
If any uncomfortable reaction develops discontinue use and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0 / 5. Sh-Oligopeptide-22 Sp is a small, water soluble peptide used at very low levels so it does not leave an occlusive film that could block pores. It has no oily carriers by itself and breaks down quickly on the skin, making it virtually impossible to clog follicles.
Because of this profile the ingredient is generally considered safe for those who are prone to acne or breakouts. As always the overall formula matters; heavy oils, waxes or silicones paired with the peptide could still trigger congestion, so check the full ingredient list.
Summary
Sh-Oligopeptide-22 Sp is a lab made fragment of the chemokine TECK that conditions skin by sending gentle signals that support surface repair and boost softness. Its tiny size lets it sit comfortably in water based serums, lotions and masks where it teams up with hydrators to calm and refresh stressed complexions.
While not yet a household name the peptide has been carving out a spot in premium and post-procedure skincare thanks to its mild nature and versatility. Current data shows it is well tolerated across skin types with minimal risk, still it is wise to patch test any new product to rule out individual sensitivities.