What Is Sh-Oligopeptide-73?
Sh-Oligopeptide-73 is a lab-crafted string of amino acids modeled after Substance P, a short natural protein also known as TAC 1. Because it comes from a synthetic process rather than an animal or plant, it is classed as a bio-engineered peptide. Developers first explored this molecule in wound-care studies, then noticed its skin-soothing traits, which led to its use in beauty products during the late 2000s.
Manufacturing starts with linking individual amino acids in a precise order through solid-phase peptide synthesis. Once the chain is complete, it is purified, then blended into a water-based solution or powder for easy mixing into creams and serums.
You will most often see Sh-Oligopeptide-73 in anti-aging moisturizers, calming masks, after-sun gels, eye creams and targeted treatment ampoules where gentle barrier support is needed.
Sh-Oligopeptide-73’s Cosmetic Benefits/Uses
This peptide offers a pair of helpful roles in skincare formulas
- Emollient: It softens rough patches by filling tiny gaps on the skin surface, leaving it smooth and supple
- Skin protecting: It forms a light defensive film that locks in moisture and helps shield the barrier from everyday stress like wind or pollution, which can reduce redness and tightness over time
Who Can Use Sh-Oligopeptide-73
Most skin types tolerate this peptide well. Dry, sensitive or mature complexions tend to appreciate its softening and barrier-supporting feel, while oily and acne-prone skin should not find it heavy or pore-clogging because the molecule is lightweight and non-occlusive.
Since Sh-Oligopeptide-73 is wholly synthetic and contains no animal-derived components, it fits vegan and vegetarian lifestyles.
There is no published evidence that the ingredient poses a risk to women who are pregnant or breastfeeding. That said, research in these groups is limited, so this is not medical advice and anyone who is expecting or nursing should show the product to a healthcare provider to be on the safe side.
The peptide does not absorb UV light or make skin more sun-sensitive, so there is no known photosensitivity concern. It also layers well with common actives like niacinamide or hyaluronic acid without neutralizing their effects.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Oligopeptide-73 differ between individuals. The points below outline potential yet uncommon issues. Assuming a product is well formulated and used as directed most people will not notice any problems.
- Transient redness or warmth
- Mild itching or tingling in very reactive skin
- Contact dermatitis in those allergic to peptides or preservatives used alongside it
- Rare swelling if sensitivity is high
If any discomfort or visible irritation develops stop using the product and seek advice from a medical professional
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
Sh-Oligopeptide-73 is a small, water-soluble peptide that sits lightly on the surface, absorbs quickly and does not contain heavy oils or waxes that can clog pores. No published reports link it to increased breakouts in clinical or consumer settings. Because it is manufactured at very low use levels, it ends up diluted within a formula, further lowering any pore-blocking risk. In short, it is considered friendly for those who are prone to acne or congestion.
As with most peptides, the overall pore safety of a finished product still depends on the base formula. If the cream or serum pairs this ingredient with heavier butters or comedogenic oils, the final product could still trigger breakouts even though the peptide itself is rated 0.
Summary
Sh-Oligopeptide-73 is a lab-designed peptide that works as an emollient and skin-protecting agent. It smooths rough areas by filling microscopic gaps on the surface then leaves a sheer film that locks in moisture and shields the skin from everyday stress. These actions help calm sensitivity, reduce dryness and keep the barrier resilient.
The ingredient stays under the radar compared with buzzier actives like retinol or vitamin C, yet formulators who prioritize gentle barrier care reach for it when they want a lightweight soothing boost. You will mainly spot it in specialized moisturizers, eye creams and recovery masks rather than mainstream cleansers or toners.
Safety data show low irritation potential, no known photosensitivity and negligible risk of clogging pores. Still, every skin is unique so running a small patch test when trying any new product that features Sh-Oligopeptide-73 is a smart habit.