What Is Sh-Oligopeptide-73 Amide Acetate?
Sh-Oligopeptide-73 Amide Acetate is a lab-made copy of the human protein Substance P, a short chain of 11 amino acids. Scientists link the amino acids in the same order found in our bodies, then add an amide group at one end and join it with acetic acid to form a stable salt. Because it mirrors a natural skin signal protein, the body recognizes it easily.
This peptide first gained attention in medical research for its role in calming skin responses. As peptide technology advanced, formulators saw its potential in beauty products that aim to soothe and renew the skin surface. Modern manufacturing relies on solid-phase peptide synthesis, where amino acids are added one by one on a resin support, then carefully cleaved, purified and converted to the acetate form. The result is a highly pure ingredient ready for cosmetic use.
You will most often spot Sh-Oligopeptide-73 Amide Acetate in leave-on products that target signs of aging or sensitivity. Common formats include lightweight serums, reparative creams, sheet masks and post-peel calming gels. Since it works well at low doses and is water soluble, it blends smoothly into both gel and lotion bases.
Sh-Oligopeptide-73 Amide Acetate’s Cosmetic Benefits/Uses
This peptide earns its place on ingredient lists thanks to two key functions
- Skin conditioning: Helps the skin feel softer and look more even by supporting its natural repair signals. Over time this can reduce the appearance of rough patches and fine lines while boosting overall comfort
- Skin protecting: Reinforces the skin barrier so it can better defend against daily stressors such as pollution or harsh weather. A stronger barrier means less moisture loss and fewer visible signs of irritation
Who Can Use Sh-Oligopeptide-73 Amide Acetate
Because it mirrors a natural skin messenger and is free of heavy oils or fragrances, Sh-Oligopeptide-73 Amide Acetate suits nearly every skin type, including dry, oily, combination and sensitive complexions. Its light water-soluble profile makes it unlikely to clog pores so acne-prone users can usually apply it without worry. Those with extremely reactive or allergy-prone skin should still proceed carefully, as with any new cosmetic ingredient.
The peptide is produced entirely through laboratory synthesis with no animal-derived materials, making it appropriate for vegans and vegetarians. Most finished products that feature it are also cruelty-free, though checking the brand’s overall policy is wise.
No specific data flag the ingredient as unsafe for women who are pregnant or breastfeeding. Current research has not linked topical use to hormonal disruption or systemic absorption at problematic levels. That said this is not medical advice and anyone who is pregnant or nursing should run any skincare product past a doctor to be on the safe side.
Sh-Oligopeptide-73 Amide Acetate does not increase photosensitivity so it can be used morning or night without elevating the risk of sunburn. Normal daily sunscreen habits still apply. The peptide also plays well with common actives like niacinamide, ceramides and hyaluronic acid, making it easy to slot into most routines.
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Oligopeptide-73 Amide Acetate differ from person to person. The effects listed below are only potential outcomes and they are unlikely to occur for the average user when the ingredient is properly formulated and used as directed.
- Mild redness or warmth
- Temporary itching or tingling at the application site
- Localized swelling in very sensitive individuals
- Rare allergic contact dermatitis presenting as rash or hives
- Breakouts or congestion if the surrounding formula is rich in pore-clogging ingredients
- Interaction irritation when layered immediately with strong chemical exfoliants or retinoids
If any of these reactions occur stop use immediately and seek advice from a qualified healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
Sh-Oligopeptide-73 Amide Acetate is a tiny water-soluble peptide with no oils, waxes or heavy emollients so it does not block pores on its own. Its molecules rinse away easily and do not linger inside follicles, earning it the lowest score on the comedogenic scale.
Because of this it is considered suitable for people who are prone to acne or frequent breakouts.
The finished product still matters. If the formula surrounding the peptide is loaded with thick butters or silicones, overall pore-clogging potential can rise even though the peptide itself is harmless.
Summary
Sh-Oligopeptide-73 Amide Acetate is a lab-crafted copy of Substance P that mainly conditions and protects the skin. It does this by sending calming signals that support the skin’s own repair process and by strengthening the surface barrier so moisture stays in and irritants stay out.
While peptide technology in general is popular, this specific ingredient is still a bit of an insider pick found mostly in higher-end serums and targeted soothing products. Interest is growing as more brands look for gentle actives that suit sensitive skin.
Current research and user reports point to a high safety profile with minimal risk for irritation or breakouts when used as directed. As with any new skincare item, patch testing is smart to confirm personal tolerance before full-face use.