What Is Sh-Oligopeptide-73 Amide Trifluoroacetate?
Sh-Oligopeptide-73 Amide Trifluoroacetate is a lab-made copy of the human signaling protein Substance P. It consists of 11 amino acids arranged in the same order our bodies use, with the end of the chain capped as an amide to boost stability. The peptide is paired with trifluoroacetic acid to form a salt, which helps keep it solid and easy to handle in cosmetic labs.
This ingredient was first explored in wound-healing studies where Substance P showed it could calm irritation and prompt skin repair. Chemists later adapted the molecule for beauty products, trimming its size so it could sit on the skin surface without breaking down too quickly. Today it is made through solid-phase peptide synthesis, a step-by-step process that joins protected amino acids on a resin bead, then washes away leftover reagents before adding the trifluoroacetate counterion.
Because of its stability and skin-comforting nature, Sh-Oligopeptide-73 Amide Trifluoroacetate is found in soothing sheet masks, anti-aging serums, post-peel recovery gels, barrier-support moisturizers and eye treatments that aim to reduce the look of redness or fatigue.
Sh-Oligopeptide-73 Amide Trifluoroacetate’s Cosmetic Benefits/Uses
When added to skincare formulas this peptide delivers several helpful actions:
- Antioxidant – helps neutralize free radicals generated by UV light and pollution which can lead to dullness and early wrinkles
- Humectant – attracts water to the upper skin layers keeping them hydrated plump and comfortable
- Skin protecting – supports the natural barrier so skin is better able to defend itself against dryness irritants and environmental stress
Who Can Use Sh-Oligopeptide-73 Amide Trifluoroacetate
This peptide is generally well tolerated by all skin types including dry, oily, combination sensitive and mature skin. Its lightweight water-loving nature means it will not clog pores so even acne-prone users usually do well with it. Those with extremely reactive or allergy-prone skin should still approach any new ingredient cautiously as individual sensitivities are possible.
The molecule is produced completely in a lab with no animal inputs so it is suitable for vegans and vegetarians. It is also typically included at low concentrations that do not affect the animal-free status of a finished formula.
Current research shows no evidence that topical Sh-Oligopeptide-73 Amide Trifluoroacetate poses a specific risk to pregnant or breastfeeding women. That said this is not medical advice and anyone who is pregnant or nursing should review any skincare product with their physician to be safe.
The peptide does not make skin more sensitive to sunlight so it is not considered photosensitizing. As always daily sunscreen is still recommended for overall skin health. The ingredient layers well with common actives like niacinamide retinol AHAs and ceramides and has no known issues with makeup wear or SPF performance.
Potential Side Effects/Adverse Reactions
Side effects from topical Sh-Oligopeptide-73 Amide Trifluoroacetate can vary from person to person. The points below outline potential reactions although most users will not experience them when the ingredient is formulated correctly:
- Mild redness or warmth at the application site
- Temporary stinging or tingling, especially on compromised skin
- Itchiness linked to individual peptide sensitivity
- Rare allergic contact dermatitis presenting as swelling or rash
- Breakout or pore congestion if combined with heavy occlusives in very oil-rich formulas
If any persistent irritation or unexpected reaction occurs stop using the product and consult a qualified healthcare professional.
Comedogenic Rating
Comedogenic rating: 0/5. Sh-Oligopeptide-73 Amide Trifluoroacetate is a small water soluble peptide that rinses off cleanly and does not form a greasy layer on the skin. Because it is free of oils, waxes or heavy silicones it has no realistic way to plug pores.
As a result it is considered safe for those who struggle with acne or recurring breakouts.
Only the full formula can determine if a finished product is pore friendly, so people who are extremely clog prone should still check the other ingredients alongside this peptide.
Summary
Sh-Oligopeptide-73 Amide Trifluoroacetate acts as an antioxidant by helping mop up free radicals before they chip away at collagen, works as a humectant by binding moisture to keep the surface supple and supports the skin barrier so it can fend off dryness and irritants. These actions stem from its amino acid sequence which lets it interact with water molecules, cell messengers and unstable oxygen species.
The peptide is not yet a household name but it is gaining a quiet following in calming serums eye gels and post-procedure masks where fast comfort and light hydration are prized.
Current data shows it is low risk for irritation or pore blockage when used at the levels found in cosmetics. Even so every skin is different so it is smart to patch test any new product that features this ingredient before putting it into daily rotation.