What Is Sh-Oligopeptide-75 Sh-Oligopeptide-1?
Sh-Oligopeptide-75 Sh-Oligopeptide-1 is a lab-designed fusion peptide made up of 67 amino acids, created by joining two shorter peptide genes then expressing the new gene in a harmless strain of E. coli. After fermentation the peptide is separated, purified and stabilized so it can be added to skin care formulas. Peptides like this began drawing attention in the early 2000s when researchers noticed their ability to signal skin cells in ways that support a smoother, healthier look. Brands looking for gentler alternatives to retinoids or acids soon started blending these lab-made peptides into serums, lightweight moisturizers, concentrated ampoules, sheet masks and targeted eye or neck creams.
Sh-Oligopeptide-75 Sh-Oligopeptide-1’s Cosmetic Benefits/Uses
In topical products this ingredient serves one main purpose: skin conditioning. By interacting with the skin’s surface proteins it helps keep the outer layer soft, hydrated and more resilient which can translate to a plumper appearance, improved texture and a fresher overall look in daily use.
Who Can Use Sh-Oligopeptide-75 Sh-Oligopeptide-1
This peptide is generally suitable for all main skin types including dry, normal, combination and oily because it conditions without adding heavy oils or clogging pores. Sensitive skin usually tolerates it as well since it lacks fragrance and known sensitizers, though highly reactive skin should still proceed cautiously. There are no specific concerns for darker skin tones or acne-prone complexions.
The material is produced through microbial fermentation, not extracted from animals, so it aligns with vegan and vegetarian preferences. No animal testing is inherent to the production process, though finished product policies vary by brand.
Current data does not flag the peptide as unsafe for pregnant or breastfeeding women, yet formal studies in these groups are limited. This text is not medical advice, and anyone who is expecting or nursing should discuss any new skincare product with a qualified healthcare provider before use.
Sh-Oligopeptide-75 Sh-Oligopeptide-1 is not known to cause photosensitivity, so there is no extra sun-care requirement beyond daily sunscreen that dermatologists already recommend. It can be used morning or night and pairs well with most common actives because it is stable in the typical pH range of leave-on products.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Oligopeptide-75 Sh-Oligopeptide-1 differ from person to person. The effects listed below are only possibilities, and properly formulated products rarely trigger them.
- Mild redness or warmth at the application site
- Transient stinging on very sensitive skin
- Itchiness or tightness linked to overuse in compromised skin barriers
- Allergic contact dermatitis in individuals already sensitized to peptides or preservatives in the formula
- Breakouts if the finished product contains comedogenic accompanying ingredients
- Loss of efficacy when layered immediately after highly acidic products that can destabilize peptides
If any irritation or unexpected reaction occurs stop using the product and seek advice from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0 / 5
Sh-Oligopeptide-75 Sh-Oligopeptide-1 is a water-soluble peptide with no oily or waxy components, so it does not obstruct pores or leave a film that can trap sebum. Peptides of this size are typically used at very low concentrations and are fully dissolved into the base formula, further lowering any clogging risk. For these reasons the ingredient is considered non-comedogenic and is suitable for skin that is prone to acne or breakouts.
Its final comedogenic impact will still depend on the overall product vehicle; heavy creams or balms that include this peptide could feel occlusive even if the peptide itself is not.
Summary
Sh-Oligopeptide-75 Sh-Oligopeptide-1 is a lab-crafted 67-amino-acid peptide that conditions skin by signaling surface cells and supporting a smoother more hydrated appearance. It is prized for being gentle, vegan friendly and compatible with most active ingredients. While it has gained some traction in modern serums and eye creams it is not yet as mainstream as classics like hyaluronic acid or niacinamide, mainly because peptides are newer and costlier to formulate.
Current safety data rates the ingredient as low-risk with minimal irritation potential. Users should still carry out a quick patch test whenever trying a new product that contains this peptide to rule out personal sensitivities and ensure the whole formula suits their skin.