What Is Sh-Oligopeptide-76?
Sh-Oligopeptide-76 is a lab-made protein fragment made up of 16 amino acids that copy a short stretch of the human protein Beta Defensin 103. Scientists synthesize the peptide from the 20 standard amino acids used in all living things, linking them in the exact order found in the natural fragment. This bio-identical design lets the peptide fit smoothly into skin care formulas while keeping batch quality consistent. Interest in defensin-inspired peptides began in the early 2000s when researchers noted their role in healthy skin. Brands soon explored shorter, easier-to-make fragments like Sh-Oligopeptide-76 to provide similar skin benefits without the high cost of full-length proteins. Production starts with solid-phase peptide synthesis, where each amino acid is added step by step to a growing chain, then the finished peptide is purified and blended into a stable cosmetic grade powder. You will most often see Sh-Oligopeptide-76 in leave-on products such as anti-aging serums, hydrating lotions, sheet masks and targeted eye or neck treatments that aim to keep skin looking smooth and balanced.
Sh-Oligopeptide-76’s Cosmetic Benefits/Uses
This peptide is valued for one main role in skin care.
As a skin conditioning agent, Sh-Oligopeptide-76 helps support a healthy skin surface by reinforcing the moisture barrier and promoting a soft, supple feel. Regular use can leave skin looking more even and refreshed which is why formulators add it to products that promise smoother texture and improved resilience.
Who Can Use Sh-Oligopeptide-76
This peptide is generally gentle and suits most skin types including dry, normal, combination and oily. Its light texture and barrier supporting action mean it rarely feels heavy or greasy, which makes it comfortable for acne-prone or sensitive skin as well. There are no known skin types that must avoid the ingredient, though anyone with a history of very reactive skin should always pay attention to how their skin feels when trying any new product.
Because Sh-Oligopeptide-76 is produced entirely in the lab and contains no animal-derived material, it is considered suitable for both vegans and vegetarians.
Research on topical use during pregnancy or breastfeeding is limited. The peptide is not known to penetrate deeply or act hormonally, so it is unlikely to pose a risk. Still, this is not medical advice. Pregnant or nursing individuals should ask their doctor before adding any new skin care product, just to be safe.
The ingredient does not increase photosensitivity, so it will not make skin more prone to sunburn. Regular daily sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to Sh-Oligopeptide-76 can differ from person to person. The issues listed below are only potential side effects and most users will not experience them when the ingredient is formulated and used correctly.
- Mild redness or warmth at the application site
- Temporary itching or tingling as the product settles
- Dryness if the formula contains other dehydrating ingredients
- Allergic contact dermatitis in individuals sensitive to peptides or other formula components
- Stinging when applied to broken or freshly exfoliated skin
If any unwanted reaction occurs, stop using the product and seek guidance from a healthcare professional or dermatologist.
Comedogenic Rating
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Sh-Oligopeptide-76 is water-soluble, used at very low concentrations and contains no heavy oils or waxes that typically clog pores. Because it sits lightly on the skin and is quickly absorbed, it earns the lowest possible comedogenic score.
This makes the peptide well suited for people who are prone to acne or frequent breakouts.
No special considerations related to pore blockage have been reported in the scientific or consumer literature, so formulators generally view it as a safe add-in even for oil-control or blemish-focused products.
Summary
Sh-Oligopeptide-76 is a lab-crafted 16-amino-acid fragment that conditions skin by supporting the moisture barrier, helping the surface stay soft and resilient. Its small size allows it to integrate smoothly into serums, lotions and masks where it works alongside humectants and emollients to improve overall texture and feel.
While defensin-inspired peptides have gained attention in professional circles, this specific fragment is still a niche ingredient so you will not find it in every drugstore product yet. Brands that focus on targeted anti-aging or barrier health are the most likely to feature it.
Safety profiles show a low risk of irritation or pore clogging, making it broadly compatible with most skin types. As with any new skincare ingredient, perform a simple patch test before regular use to make sure your skin agrees with the formula.