What Is Sh-Oligopeptide-77?
Sh-Oligopeptide-77 is a lab-designed fragment of the human noggin protein made up of 11 amino acids. Scientists first explored short peptides like this in the search for gentle anti-aging tools that could mimic natural skin signals. To create it, researchers build a copy of the relevant human gene, place it inside a harmless strain of E. coli and let the bacteria ferment in a nutrient broth. The cells then manufacture the peptide, which is purified, filtered and dried before being blended into cosmetic bases.
Because the molecule is small it can sit comfortably in lightweight water-based formulas without breaking down. Brands add it to anti-aging serums, sheet masks, soothing post-procedure gels, daily moisturizers and targeted eye or neck creams where a silky feel and quick absorption are needed.
Sh-Oligopeptide-77’s Cosmetic Benefits/Uses
In skin care this ingredient is valued for one key role.
Skin conditioning: Sh-Oligopeptide-77 helps skin feel softer and smoother, supports a balanced moisture barrier and can give a temporarily plumper look to fine lines. It also leaves formulas with a pleasant glide so products spread evenly without a greasy after-feel.
Who Can Use Sh-Oligopeptide-77
Because it is a lightweight water-soluble peptide, Sh-Oligopeptide-77 tends to suit all skin types including dry, oily, combination and sensitive. It conditions without clogging pores or leaving residue so even acne-prone skin can usually tolerate it. No specific skin type needs to avoid it unless a personal allergy to the finished formula exists.
The peptide is made through bacterial fermentation rather than from animal tissue which makes it appropriate for vegans and vegetarians. As always final product status can depend on the brand’s overall sourcing and animal testing policies.
Current data shows no link between topical Sh-Oligopeptide-77 and problems during pregnancy or while nursing, yet safety studies in these groups are limited. This information is not medical advice; anyone who is pregnant or breastfeeding should run any new skincare product past a healthcare professional before use.
Sh-Oligopeptide-77 does not increase photosensitivity so it will not make skin more prone to sunburn. Regular daytime sunscreen is still recommended to guard against everyday UV damage.
Potential Side Effects/Adverse Reactions
Responses to skincare ingredients vary from person to person. The issues listed below are possible yet uncommon when Sh-Oligopeptide-77 is used in a well-formulated product.
- Mild redness or itching
- Transient stinging or warmth after application
- Allergic contact dermatitis with swelling or rash
- Rare acne flare-up in very oily or congestion-prone skin
- Eye irritation if the product moves into the eye area
If you experience any of these reactions discontinue use and consult a qualified medical professional.
Comedogenic Rating
Rating: 0 out of 5. Sh-Oligopeptide-77 is a small water-soluble peptide that dissolves fully in the watery phase of a formula and leaves no oily film behind. It does not sit inside pores or create a waxy layer that could trap dead cells or sebum so it earns the lowest possible comedogenic score.
Because of this rating the ingredient is generally suitable for skin that is prone to acne or frequent breakouts.
Only the finished product’s overall mix of oils, butters and silicones would change its pore-clogging potential so always judge the complete ingredient list rather than this peptide alone.
Summary
Sh-Oligopeptide-77 is a lab-crafted fragment of the human noggin protein that acts as a skin-conditioning agent. It helps skin feel softer smoother and slightly plumper by supporting surface hydration and lending a silky glide to formulas without heaviness. Though peptides are trending, this specific one is still a niche choice so you will mainly spot it in select anti-aging serums masks or post-procedure gels rather than in everyday drugstore creams.
Current data shows Sh-Oligopeptide-77 to be low risk for irritation sensitization or pore clogging and it is considered safe for most skin types including sensitive or acne prone. As with any new skincare ingredient it is wise to perform a quick patch test when trying a product that contains it just to be sure your skin agrees with the formula.