What Is Sh-Oligopeptide-78?
Sh-Oligopeptide-78 is a lab-crafted version of a short human protein fragment. Scientists start with a synthesized copy of the gene that appears in several Type II keratin proteins, the same family of proteins that give hair its strength and flexibility. This gene is inserted into E. coli bacteria, which then ferment and churn out the peptide in large quantities. After fermentation the peptide is purified, checked for the correct chain length of up to 123 amino acids, and tested to confirm that any natural features such as disulfide bridges or sugar attachments are present and stable.
The cosmetic world’s interest in this peptide grew alongside advances in biotechnology during the early 2000s when brands began looking for bio-identical ingredients that could support healthier hair and scalp without relying on animal sources. Because it mimics a fragment of human keratin it quickly attracted formulators who wanted a gentle yet effective way to smooth, strengthen and freshen hair.
Today you will most often see Sh-Oligopeptide-78 in leave-in conditioners, rinse-off shampoos, hair masks, scalp serums and restorative treatments aimed at dry, over-processed or brittle hair. Its mild profile also makes it a candidate for sensitive-scalp products where harsh surfactants are avoided.
Sh-Oligopeptide-78’s Cosmetic Benefits/Uses
This peptide contributes two key actions that boost the performance of hair care formulas.
- Hair conditioning: Because it resembles natural keratin fragments, Sh-Oligopeptide-78 can bond lightly to damaged areas along the cuticle, helping smooth rough spots and reduce friction. The result is softer, shinier hair that detangles more easily and resists breakage.
- Cleansing: Its amino acid structure can support mild cleansing systems by helping loosen surface grime and excess sebum without stripping. When paired with gentle surfactants it improves rinseability leaving hair feeling clean yet conditioned.
Who Can Use Sh-Oligopeptide-78
Sh-Oligopeptide-78 is considered gentle enough for all scalp and hair types including oily, dry, sensitive and combination. Its bio-identical structure means it rarely disrupts the scalp barrier so even those prone to irritation can usually tolerate it. There are no known reasons for people with specific skin conditions to avoid it unless they have a documented allergy to peptides or fermentation by-products.
The peptide is produced in a microbial fermenter using a synthesized human gene, with no animal or animal-derived inputs, making it suitable for both vegans and vegetarians.
Current ingredient safety data show no reproductive or developmental concerns, so products containing Sh-Oligopeptide-78 are generally viewed as pregnancy and breastfeeding friendly. That said this is not medical advice; anyone who is pregnant or nursing should run any hair or scalp product past their doctor to be on the safe side.
Sh-Oligopeptide-78 does not cause photosensitivity, so it will not make the scalp or hair more vulnerable to sun damage. It is also color-safe and compatible with most common hair treatments such as chemical relaxers or dyes.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical use of Sh-Oligopeptide-78 can vary from person to person. The following is a list of potential issues that could occur, though most users will not experience them when the ingredient is properly formulated and used as directed.
- Mild scalp redness or itching, particularly in individuals with very sensitive skin
- Allergic contact dermatitis in those who are allergic to specific peptide sequences or fermentation residues
- Transient tingling or warmth immediately after application
- Protein buildup that can make hair feel heavy or limp if the product is overused or not rinsed properly
If any unwanted reaction occurs discontinue use immediately and consult a healthcare professional or dermatologist for guidance
Comedogenic Rating
Rating: 0 / 5
Sh-Oligopeptide-78 is a water-soluble peptide that does not leave an occlusive film on skin or scalp. It rinses away easily, contains no heavy oils or waxes and does not interact with sebum in a way that would block pores. For these reasons it earns the lowest possible comedogenic score.
Because it sits at 0 the ingredient is generally considered safe for people who are prone to acne or breakouts.
Formulas that pair the peptide with rich butters or comedogenic oils could still cause congestion, so the overall product base matters more than the peptide itself.
Summary
Sh-Oligopeptide-78 is a lab-made fragment of human keratin that conditions and lightly cleanses hair. It attaches to damaged cuticles to smooth and strengthen strands while its amino acid profile helps lift away surface grime without stripping.
The peptide is slowly gaining traction in hair care, especially in leave-in conditioners and scalp serums aimed at damaged or sensitive hair types, but it is not yet a mainstream hero ingredient you will see in every aisle.
Current safety data show it to be low risk for irritation, noncomedogenic and suitable for vegans, pregnant individuals and color-treated hair. Even with its gentle track record it is smart to patch test any new product containing Sh-Oligopeptide-78 to make sure it plays well with your unique skin and scalp.