What Is Sh-Oligopeptide-82?
Sh-Oligopeptide-82, sometimes listed as hSDF-1 or SDF-1, is a lab-made fragment of a naturally occurring signaling protein called stromal cell-derived factor 1. Chemically it is a short chain of amino acids, small enough to penetrate the upper layers of skin yet large enough to deliver targeted benefits. Scientists first isolated the full SDF-1 protein while studying cell communication in the 1990s. A few years later peptide researchers trimmed the molecule down to the most active segment, creating Sh-Oligopeptide-82 for easier, safer skincare use. Today it is produced through controlled fermentation, where genetically guided microorganisms build the peptide, followed by purification and drying to create a stable cosmetic-grade powder.
Because of its moisturizing and skin conditioning properties, Sh-Oligopeptide-82 is added to a range of leave-on and rinse-off products. You might find it in lightweight serums, anti-aging creams, sheet masks, post-sun soothing gels and even hydrating facial mists. Formulators like it because it pairs well with common bases such as hyaluronic acid, glycerin and botanical extracts without altering texture or scent.
Sh-Oligopeptide-82’s Cosmetic Benefits/Uses
In skincare formulas Sh-Oligopeptide-82 works mainly in two ways, both aimed at keeping skin comfortable and healthy looking.
- Humectant: This peptide can attract and bind water, helping the skin surface hold onto moisture. Products containing it feel more hydrating and can temporarily plump fine lines by improving water content in the outer skin layer
- Skin Conditioning: By supporting the skin’s natural barrier and signaling a fresher appearance, Sh-Oligopeptide-82 leaves the complexion softer, smoother and more resilient against daily stress
Who Can Use Sh-Oligopeptide-82
Sh-Oligopeptide-82 is generally well tolerated by all major skin types including dry, normal, combination, oily and even sensitive skin because it is lightweight and water binding rather than greasy or occlusive. People with very reactive or allergy-prone skin may still wish to check the full ingredient list of any product that contains it, as irritation is usually caused by other formula components rather than the peptide itself.
The peptide is created through microbial fermentation so it contains no animal-derived material, making it suitable for both vegans and vegetarians. It is also fragrance free and colorless in its raw form, which further widens its compatibility for ethical or ingredient-conscious users.
No published data link Sh-Oligopeptide-82 to hormonal disruption or fetal risk, so pregnant or breastfeeding users can typically apply it without special restrictions. That said, this is not medical advice and anyone who is expecting or nursing should run all skincare choices by a qualified healthcare professional to be safe.
The ingredient is not known to cause photosensitivity. Daytime products that feature it often pair well with SPF but the peptide itself does not make skin more sun sensitive. There are also no reported interactions with common actives such as retinol, vitamin C or niacinamide, allowing it to slot easily into existing routines.
Potential Side Effects/Adverse Reactions
Individual responses to topical Sh-Oligopeptide-82 can vary. The points below outline potential side effects that have been reported anecdotally or in preliminary testing yet most users who apply a properly formulated product will experience none of these issues.
- Mild stinging or warmth upon application, usually short lived
- Transient redness in very sensitive skin
- Allergic contact dermatitis in rare cases where the immune system reacts to the peptide or other formula components
- Breakouts if the overall product base is heavy or pore clogging, though the peptide itself is not comedogenic
If any discomfort, persistent redness or other adverse reaction develops stop using the product and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0/5
Sh-Oligopeptide-82 is a small, water-soluble peptide used at very low percentages, so it does not sit on the skin or trap oil the way thicker emollients can. It has no oily or waxy residues and therefore earns a solid zero on the comedogenic scale.
That makes it suitable for people who are prone to acne or breakouts.
Keep in mind the finished formula matters: if the product also contains rich butters or heavy silicones, those other ingredients could still clog pores even though the peptide itself does not.
Summary
Sh-Oligopeptide-82 is mainly a humectant and skin-conditioning peptide. It pulls moisture into the upper layers of skin then helps reinforce the barrier so the water stays put, leaving skin softer, smoother and better able to handle everyday stress.
While not a household name like hyaluronic acid, the ingredient is slowly gaining traction in serums, masks and after-sun gels thanks to its gentle hydration profile and vegan fermentation origin.
Current research and decades of peptide use suggest it is safe for most users with minimal risk of irritation, allergy or pore blockage, but as with any new skincare ingredient it is wise to perform a quick patch test before slathering it all over your face.