What Is Sh-Oligopeptide-82 Amide?
Sh-Oligopeptide-82 Amide is a lab made copy of beta defensin 103, a small chain of amino acids that naturally sits on human skin and helps keep it balanced. In a cosmetic setting chemists build this peptide through controlled synthesis, linking each amino acid one by one until the exact sequence is finished, then adding an amide group to help keep the chain stable. Because it is produced in a sterile factory setting, no animal or human tissue is harvested, which keeps the process ethical and consistent.
The peptide started attracting attention in skin care research in the early 2000s when scientists noticed its ability to draw in water and support the skin barrier. Brands soon looked for ways to add a gentle version into topical products, and the “Sh-” prefix—short for “synthetic human”—was adopted to show it is a bioidentical but lab made ingredient.
You will usually spot Sh-Oligopeptide-82 Amide in lightweight serums, sheet masks, eye gels, anti-aging creams, post-treatment balms and daily moisturizers that focus on hydration and comfort. It is often paired with hyaluronic acid, ceramides or soothing botanicals to round out a formula aimed at keeping skin plump and calm.
Sh-Oligopeptide-82 Amide’s Cosmetic Benefits/Uses
This peptide brings several helpful actions to a skin care formula:
- Humectant: Attracts moisture from the surrounding air and the deeper layers of skin, which helps keep the surface hydrated and looking fresh
- Skin conditioning: Supports the natural barrier so skin feels soft, smooth and less tight after cleansing or exposure to dry air
- Emollient: Fills in tiny gaps between skin cells creating a silky finish and reducing rough texture
Who Can Use Sh-Oligopeptide-82 Amide
This peptide is gentle enough for almost all skin types. Dry or mature complexions appreciate its water-attracting ability while oily and combination skins benefit from the lightweight feel that will not clog pores. Sensitive skin usually tolerates it well because it does not contain fragrance or harsh solvents, though extremely reactive skin should still approach new formulas carefully.
Because Sh-Oligopeptide-82 Amide is produced entirely in a lab with no animal derivatives it is suitable for vegans and vegetarians.
Current research shows no specific concerns for women who are pregnant or breastfeeding. That said this is not medical advice and anyone expecting or nursing should check with a doctor before adding new products just to be safe.
The ingredient does not heighten photosensitivity so it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Oligopeptide-82 Amide vary from person to person. The issues below are possible but unlikely when the ingredient is formulated and used as intended.
- Mild redness or warmth right after application in very sensitive skin
- Temporary stinging if applied to freshly exfoliated or compromised skin
- Rare allergic reaction to the peptide or other ingredients in the finished product, leading to itching or swelling
- Contact dermatitis triggered by a preservative or fragrance that shares the formula rather than the peptide itself
If any uncomfortable reaction develops stop using the product and seek advice from a healthcare professional
Comedogenic Rating
Rating: 0/5 — Sh-Oligopeptide-82 Amide is a water-soluble peptide that does not contain heavy oils or waxes and does not sit in the pore in a way that blocks sebum flow. Because it absorbs into the upper layers quickly and lacks fatty components it is considered non-comedogenic.
Suitable for acne-prone or breakout-prone skin.
No notable interactions with common acne treatments like benzoyl peroxide or salicylic acid have been reported, so it can usually be layered without issue.
Summary
Sh-Oligopeptide-82 Amide works as a humectant, skin conditioner and emollient by drawing water to the surface, reinforcing the natural moisture barrier and smoothing tiny gaps between cells for a softer texture. These actions keep skin hydrated comfortable and touchably smooth.
While not yet a household name it is steadily gaining traction in modern formulas that aim for a soothing light finish, often appearing alongside hyaluronic acid and ceramides.
Current research and user reports show it is low risk for irritation or pore clogging, making it safe for most skin types. As with any new cosmetic ingredient a small patch test is still the smartest way to rule out personal sensitivities before full-face use.