Sh-Oligopeptide-85 Sp: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sh-Oligopeptide-85 Sp?

Sh-Oligopeptide-85 Sp is a lab-designed short chain of amino acids created to act like the skin’s own building blocks. It is classified as an oligopeptide, meaning it is made of only a handful of linked amino acids, which allows it to stay small enough to blend smoothly into cosmetic formulas. Unlike plant or animal extracts, this peptide is produced through controlled fermentation or solid-phase peptide synthesis where individual amino acids are joined in a specific order. The purified material is then spray-dried into a fine powder and blended with a carrier so it can be evenly dispersed in creams, lotions or serums. Peptides first gained attention in the early 2000s for their skin-conditioning properties and Sh-Oligopeptide-85 Sp is one of the newer variants created to deliver those benefits in a gentler, more stable format. You will usually spot it in moisturizers, anti-aging serums, sheet masks and overnight treatments where formulators want to boost skin softness without adding heavy oils.

Sh-Oligopeptide-85 Sp’s Cosmetic Benefits/Uses

In skincare formulas Sh-Oligopeptide-85 Sp works mainly as an emollient, meaning it helps smooth and soften the surface of the skin. By filling in tiny gaps between dead skin cells it leaves the complexion feeling supple and looking more even. This silky feel also improves the spreadability of a product so it glides on easily and locks in lightweight moisture.

Who Can Use Sh-Oligopeptide-85 Sp

This peptide suits most skin types including normal, dry, combination and oily because it moisturizes without clogging pores or leaving a greasy film. Sensitive skin generally tolerates it well thanks to its small molecular size and lack of fragrance, though anyone prone to peptide allergies should stay alert. Its lab made origin means no animal by-products are involved so it is considered vegan and vegetarian friendly.

Current safety data shows no direct concerns for women who are pregnant or breastfeeding when the peptide is used topically at the low levels found in cosmetics. That said this is not medical advice and anyone expecting or nursing should ask a doctor before adding new skincare just to be safe.

Sh-Oligopeptide-85 Sp does not make skin more prone to sunburn so it is not viewed as photosensitizing. It can be layered under sunscreen during the day without affecting UV protection. There are no known ingredient conflicts or special storage needs beyond keeping the product sealed and away from extreme heat.

Potential Side Effects/Adverse Reactions

Responses to topical Sh-Oligopeptide-85 Sp differ from person to person. The points below outline potential issues, yet most users experience none of these when the ingredient is formulated and used correctly.

  • Mild redness or warmth
  • Tingling or stinging on application
  • Itchiness or minor swelling
  • Contact dermatitis in individuals allergic to peptides or formulation excipients
  • Breakouts in very acne-prone skin if the finished product contains comedogenic co-ingredients

If you develop any of the above reactions stop use and consult a healthcare professional.

Comedogenic Rating

Rating: 0 / 5

Sh-Oligopeptide-85 Sp is a tiny water soluble peptide that does not behave like heavy oils or waxes that can block pores. Because it simply sits on the skin to create a silky feel then absorbs without leaving residue, it is considered non comedogenic. This makes it an appropriate choice for acne prone or easily congested skin. Keep in mind that the finished product’s overall formula, not just this peptide, determines if breakouts occur.

No notable interactions with sebum production or skin microbiome have been recorded, so its comedogenic profile remains low even with prolonged use.

Summary

Sh-Oligopeptide-85 Sp is mainly valued as an emollient that fills microscopic gaps between skin cells, leaving the surface softer and smoother while helping creams spread with a light touch. Its petite amino acid chain allows it to blend seamlessly into water based or oil free formulas without adding weight.

Although it is not yet a blockbuster ingredient plastered across marketing campaigns, formulators like it for its stability and vegan friendly origin. You will spot it most often in mid range moisturizers and specialty serums aimed at boosting skin comfort.

Current research and usage reports show Sh-Oligopeptide-85 Sp is safe for the vast majority of users with minimal risk of irritation or pore clogging. As with any new skincare addition, perform a small patch test first to confirm personal tolerance.

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