What Is Sh-Oligopeptide-86?
Sh-Oligopeptide-86 is a lab made fragment of a larger protein known as MDC-15, part of the family of metalloprotease and RGD disintegrin proteins found naturally in the body. Scientists isolated the active segment, then recreated it through precise fermentation and purification steps that use genetically guided bacteria. The result is a short chain of amino acids small enough to sit on the skin’s surface yet stable enough for use in creams and serums.
The cosmetic world first noticed this peptide while studying how cells renew and repair themselves. Early research showed it could signal fresher looking skin, so formulators began adding it to high end moisturizers at the start of the 2010s. Today the ingredient appears in anti-aging lotions, sheet masks, concentrated serums, eye creams and post-treatment soothing gels. Its popularity comes from the fact that it plays nicely with most other common skincare ingredients and does not need heavy preservatives to stay active.
Sh-Oligopeptide-86’s Cosmetic Benefits/Uses
This peptide is valued for one key action in skincare products.
Skin conditioning: Sh-Oligopeptide-86 supports a smoother, softer feel by helping the skin hold on to water and by encouraging a more even surface. Regular use can lead to skin that looks plump, refined and comfortable which is why it shows up in formulas aimed at reducing the look of fine lines or dryness.
Who Can Use Sh-Oligopeptide-86
Most skin types tolerate Sh-Oligopeptide-86 well, including dry, oily, combination and sensitive complexions because it is lightweight and non-greasy. People with extremely reactive or allergy-prone skin should still approach new products with extra care since any peptide can rarely trigger irritation in these groups.
The peptide is produced in a lab through bacterial fermentation so no animal ingredients are involved, making it suitable for both vegans and vegetarians.
Current data shows no specific risks for pregnant or breastfeeding women when the ingredient is applied topically. This text is not medical advice and anyone who is expecting or nursing should review any skincare routine with a qualified healthcare provider to be safe.
Sh-Oligopeptide-86 does not cause photosensitivity and can be used morning or night without increasing the skin’s vulnerability to the sun. It also layers well with most common actives such as niacinamide, vitamin C and retinol without losing potency.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Oligopeptide-86 differ from person to person. The points below cover possible reactions, though they are uncommon when products are formulated and used correctly.
- Mild redness or warmth
- Temporary stinging or itching
- Localized swelling in people with peptide allergies
- Small breakouts if combined with very heavy occlusive bases
- Reduced effectiveness when layered directly after strong acids that can break down peptides
If any irritation or unexpected reaction occurs stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0/5 (non-comedogenic). Sh-Oligopeptide-86 is a tiny water-soluble peptide that does not leave an oily film or clog pores on its own. It disperses easily in lightweight serums and gels so it rarely traps dead skin cells or excess sebum. Because of this, it is generally suitable for acne-prone or breakout-prone skin. If the finished product pairs the peptide with very rich butters or waxes, those other ingredients would be the pore-clogging concern, not the peptide.
Summary
Sh-Oligopeptide-86 is a lab crafted amino acid chain that conditions skin by boosting surface hydration and supporting a smoother, plumper look. Its small size allows it to sit comfortably on the skin, signalling a fresher appearance without feeling heavy. The peptide has found a modest but steady following in anti-aging creams, eye treatments and soothing post-procedure gels thanks to its gentle nature and compatibility with popular actives like niacinamide or vitamin C.
Current research and user reports show it is well tolerated across most skin types, including sensitive and acne-prone complexions, with side effects remaining rare and mild. As with any new ingredient it is wise to do a quick patch test when trying a product that contains Sh-Oligopeptide-86 to confirm personal tolerance.