What Is Sh-Oligopeptide-94 Sp?
Sh-Oligopeptide-94 Sp is a lab engineered version of a short chain protein fragment known as Humanin, a naturally occurring peptide found in human cell mitochondria. Its compact size lets it pass through the outer layers of skin with ease, delivering protective signals to the cells beneath. Although Humanin itself was first identified in the early 2000s during studies on cellular stress, it was only after further research that cosmetic chemists recognized its potential for topical skin care. Today the peptide is produced through precision fermentation, where genetically programmed bacteria or yeast churn out the exact amino acid sequence. After purification and stabilization the ingredient is blended into water based solutions, making it easy to add to a wide range of formulas. You will most often spot Sh-Oligopeptide-94 Sp in protective serums, anti aging creams, recovery masks and day moisturizers designed for sensitive or environmentally stressed skin.
Sh-Oligopeptide-94 Sp’s Cosmetic Benefits/Uses
In a skin care formula Sh-Oligopeptide-94 Sp functions primarily as a skin protecting agent, helping the complexion cope with everyday stressors. By supporting natural defense pathways it can reduce visible signs of irritation, maintain a smoother surface and keep the skin barrier feeling resilient, which in turn allows other beneficial ingredients like hydrators and antioxidants to work more effectively.
Who Can Use Sh-Oligopeptide-94 Sp
Because it is designed to calm and reinforce the skin barrier, Sh-Oligopeptide-94 Sp is generally well suited to all skin types, from dry or mature to oily and breakout prone. Its lightweight, water soluble nature means it will not clog pores or leave a greasy film, making it comfortable even for combination or acne-prone complexions. People with very reactive or compromised skin often appreciate its barrier supporting action, though anyone with a known peptide allergy should proceed with caution.
The peptide is manufactured through fermentation rather than being taken from animal tissue, so products containing Sh-Oligopeptide-94 Sp are typically considered vegan and vegetarian friendly. Always check the full ingredient list, as other components in the formula might differ.
No current data links topical Humanin derivatives with risks during pregnancy or breastfeeding, yet research on expectant mothers is limited. This information is not medical advice; anyone who is pregnant or nursing should consult a healthcare professional before adding new skincare to their routine.
Sh-Oligopeptide-94 Sp does not make skin more sensitive to sunlight, so there is no elevated need for sun avoidance beyond standard daily SPF use. It also plays well with most actives, including antioxidants and ceramides, though layering it with strong exfoliating acids could heighten the chance of irritation for those with delicate skin.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Oligopeptide-94 Sp differ from person to person. The points below list potential side effects, yet they are uncommon when the ingredient is included at appropriate levels in a well-formulated product.
- Mild redness or warmth shortly after application
- Transient itching or tingling as the peptide absorbs
- Localised swelling in individuals sensitive to peptides
- Contact dermatitis if combined with highly sensitising ingredients
- Eye irritation if the product migrates too close to the lash line
If any persistent or severe reaction occurs, discontinue use immediately and seek advice from a qualified healthcare provider or dermatologist.
Comedogenic Rating
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Sh-Oligopeptide-94 Sp is a small water soluble peptide that contains no oils or waxes, so it does not lodge in pores or leave a film behind. This places it at the lowest end of the comedogenic scale.
Its non-comedogenic nature makes it suitable for skin that is prone to acne or frequent breakouts.
Keep in mind that the overall pore friendliness of a finished product will also depend on the other ingredients in the formula, especially any heavy butters or silicones.
Summary
Sh-Oligopeptide-94 Sp is a synthetic Humanin peptide that helps skin defend itself, easing irritation, reinforcing the barrier and creating a smoother looking surface. It delivers these benefits by penetrating easily and prompting cells to fire up their natural protective responses.
Peptides are trending in skincare, yet this particular one is still a specialty ingredient found mostly in higher tier serums, barrier creams and recovery treatments.
Safety data and user experience point to a low risk profile, but everyone’s skin is different. Patch test any new product that contains Sh-Oligopeptide-94 Sp to make sure it agrees with you before applying it all over your face.